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내독소로 유도된 급성 폐 손상에서 게르마늄의 투여로 인한 호중구 세포사의 증가
조현국,Cho, Hyun-Gug 한국현미경학회 2005 Applied microscopy Vol.35 No.4
호중구는 다양한 원인에 의해서 발생되는 급성 폐 손상의 발병기전에 중요한 역할을 담당한다. 폐 손상 시 순환계로부터 유입된 호중구들에 대한 폐포강 대식세포의 탐식작용이 증가될 경우 손상기전에 미치는 영향을 알아 보기 위해 내독소를 흰쥐의 기관지 내로 분무하고 유기게르마늄을 복강으로 투여하였다. 실험 결과 내독소 투여 5시간 후 체중당 폐 무게와 폐 세척액 내 단백질 함량은 유의하게 (p<0.001) 증가되었으나, 게르마늄 병행 투여로 폐 무게와 단백질 함량은 현저하게 (p<0.001, p<0.01) 감소되었다. 내독소 투여군은 폐 손상과 함께 폐포강 내 호중구는 유의하게 (p<0.05) 증가되었으나, 게르마늄의 투여로 감소되었고 폐포강 내 탐식된 호중구의 비율은 증가되었다. 이와 같은 결과들을 볼 때, 유기 게르마늄은 내독소증에 의한 급성 폐 손상에서 폐포강 대식세포들의 호중구 탐식작용을 증가시켜 폐 손상을 감소시킬 수 있는 것으로 나타났다. Neutrophils that influx into the alveolar spaces from circulatory bloods play a important role in pathogenesis of acute lung injury. During the acute inflammatory phase, in order to investigate the acceleration of macrophage phagocytosis to the neutrophils is able to reduce the neutrophil-derived acute lung injury, endotoxemia was induced by insufflation of lipopolysaccharide intratracheally and organic germanium was injected intraperitoneally after endotoxin treatment. At 5 h after endotoxin treatment, lung weight and BAL protein concentration are significantly increased (p<0.001) compared to sham, and that was remarkedly decreased (p<0.001, p<0.01) by injection of germanium. In addition germanium treatment resulted to decreased the number of alveolar PMNs and to increase the percentage of engulfed neutrophils by alveolar macrophages. These observations indicate that organic germanium may have a role of reduction to neutrophil-derived acute lung injury in endotoxemia.
趙顯國 한국중국문화학회 1998 中國學論叢 Vol.7 No.-
本文從現實主義(realism)角度硏究了瞿秋白的<魯迅雜感選集序言>. 瞿秋白在<序言>裏將魯迅文學的現實主義特徵定爲"淸醒的現實主義". 這個槪念在兩個方面上具有其意義與局限. 首先瞿秋白從唯物論o反映論角度解讀魯迅文學和他的思想變化軌迹, 這點置得我們注意. 他以 "正視"和 "熱情"這兩個槪念槪括魯迅現實主義的特徵. 盡管如此, 他過度强調唯物辨證法, 甚至主張사是唯一的世界觀, 從而露出了其局限. 但是他在解讀魯迅文學過程當中, 不但論述了魯迅不斷地關注當時社會現實和人生問題, 以諷刺和幽默對사們進行客觀再現, 進一步還指出了魯迅作品幷不是單純的客觀再現, 而是客觀再現裏삼透着其主觀熱情. 這個觀念是흔耐人尋味的. 瞿秋白認爲這些是淸醒現實主義的基本因素. 령一方面, 瞿秋白在<序言>裏提到了魯迅的思想和文學幷不停留在個人存在和意識的範疇, 而是사還包括魯迅對集體的關心和他個體參與集體的問題, 這點令人注意. 但是瞿秋白對魯迅個人存在意識的複雜性與集體系着如何關係沒有進行更細緻的探討, 這是他的局限.
Interleukin-1으로 유도된 흰쥐의 급성 폐손상에서 phospholipase A_2의 활성증가
조현국,문병연 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)
In order to investigate the pathogenesis of adult respiratory distress syndrome (ARDS), acute lung injury was induced in rats by insufflation of interleukin-1α (IL-1, 50 ㎍/rat) into the trachea. To identify acute edematous lung injury, five hours after IL-1 administration, lung leak index, lung lavage phospholipid content, and lung lavage protein concentrations were measured. In addition, activities of lung myeloperoxidase (MPO) and phospholipase A_2 (PLA_2), and immunocytochemical changes were examined. IL-1 increased lung leak index, phospholipid content in bronchoalveolar lavage (BAL) fluid, and BAL protein concentrations. Lung PLA_2 activity was significantly increased by IL-1 administration, compared with control. In an immunocytochemical study, PLA_2 antiserum particles were identified in alveolar type Ⅱ epithelial cytoplasm in rats given IL-1 intratracheally. Based on these experimental results, it is suggested that increased PLA_2 activity induced neutrophil-dependent oxidative lung injury and the oxidative lung injury was caused by proinflammatory lipid mediators produced by PLA_2.
조현국,임병관,문병연,이남선 대한시과학회 2011 대한시과학회지 Vol.13 No.3
Purpose: In this study, the distribution in refractive powers on lenses was investigated. Methods: We used +1.50D, ±2.00D and -3.00D spherical lenses which were distributed in Korea. Refractive powers at 0~25 mm from optical center were measured, and then, their optical uniformity were surveyed according to international standards. Results: Refractive power, power error and frequency measured cylindrical power were increased respectively as optical point was far from optical center. In the case of (-) lenses, most of powers which were measured at 20~25 mm from optical center exceeded the tolerance. There were no cases exceeding tolerance for (+) lenses. Conclusions: The hard process control and precision quality control will be essential to secure a higher competitiveness of Korean products in the domestic and foreign marketplace.