레니텍^® 정(말레인산 에날라프릴, 10 mg)에 대한 에나레이스 정의 생물학적 동등성

조성희,하용화,홍성제,서성훈,류재환,김동현,이경태,Cho, Sung-Hee,Ha, Yong-Hwa,Hong, Sung-Je,Seo, Seong-Hoon,Rew, Jae-Hwan,Kim, Dong-Hyun,Lee, Kyung-Tae 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.

중국 거주 한국인의 주생활특성 연구

조성희,손진희,Cho, Sung-Heui,Son, Jin-Hee 한국주거학회 2005 한국주거학회 논문집 Vol.16 No.6

It is possible to explain the design, the meaning, and the use of domestic space by comparing different cultures. The characteristics of Koreans' housing life living in western cultures has already been studied extensively. Because of political reasons, however, the characteristics of Koreans' housing life living in Chinese culture has hardly been studied at all. The purpose of this study was to find out the characteristics of succession and transformation of domestic housing culture. The data was collected by questionnaire methods from fifty Korean households and eleven Chinese households. Individual interviews and actual surveys, including taking pictures were also used for data collection. The results of this study were as follows (1)An analysis of heating system usage behaviors showed the importance of heated floors, known as Ondol, is one of the enduring characteristics of domestic habits. (2)In the sitting style, the traditional sitting on the floor was shown in living room. (3)Regarding room usage behavior, Korean households were centered around the living room in chinese houses. (4)An analysis of space organization preferences with respect to common spaces revealed that Korean households tend to prefer the open plan of common spaces.

1세 이하의 소아에서 발병한 신증후군의 임상적 고찰

조성희,이주훈,조영미,박영서,정해일,Cho, Sung-Hee,Lee, Joo-Hoon,Cho, Young-Mi,Park, Young-Seo,Cheong, Hae-Il 대한소아신장학회 2009 Childhood kidney diseases Vol.13 No.2

저자들은 1세 이하에 발병한 신증후군 환아 7명의 진단 및 치료를 경험하였기에 보고하는 바이다. 1996년부터 2007년까지 본원에서 1세 이전에 신증후군으로 진단 받은 환아 7명을 대상으로 병록 고찰을 통해 후향적으로 조사하였다. 선천성 신증후군은 3명, 영아형 신증후군은 4명 이었고, 남아가 1명, 여아가 6명으로 여아가 많았다. 6명에서 신생검을 시행하였고, 2명에서 미만성 메산지움 경화증, 2명에서 국소분절사구체경화증, 1명에서 Finnish형 신증후군 그리고 나머지 1명에서는 미세 변화형으로 확인되었다. 4명의 환아에서 NPHS2, PLCE1, 그리고 WT1의 유전자 분석을 시행하였고 2예에서 WT1 변이가 확인되었다. 선천성 신증후군으로 진단받은 3명 중 1명은 Finnish형 신증후군, 2명은 DDS로 진단받았고, 3명 모두 패혈증으로 사망하였다. 영아형 신증후군으로 진단받은 4명 중 2명은 사망하였고, 다른 1명은 관해가 되어 치료되었고, 나머지 1명은 치료 4개월 경 말기 신부전으로 진행하여 복막투석을 하고 있다. 1세 이전에 발병하는 선천성 신증후군은 소아 신증후군에 비하여 예후가 나쁘지만, 병력의 세밀한 검토, 임상소견 및 조직검사, 유전자 분석을 통한 정확한 진단이 빠르게 이루어져 조기 투석 및 신이식 등 적극적인 치료를 한다면 생존률의 향상을 기대할 수 있을 것이다. 대부분의 1세 이전 진단받는 신증후군은 유전적 신질환으로 추후 이들 환아들에 대한 유전형-표현형의 상관관계에 대한 추가 연구가 필요하다. Purpose : This study was performed to report the diagnosis and treatment of nephrotic syndrome manifesting in the first year of life. Methods : We retrospectively reviewed the clinical data with chart review in 7 patients who were diagnosed as nephrotic syndrome manifesting in the first year of life from 1996 to 2007. Results : Three patients had congenital nephrotic syndrome, the other 4 patients had infantile nephrotic syndrome. Their ages ranged from birth to 11 months and male to female ratio was 1 to 6. Renal biopsies were done in 6 patients. One patient had Finnish type congenital nephrotic syndrome, 2 patients had diffuse mesangial sclerosis, 2 patients had focal segmental glomerulosclerosis and 1 patient had minimal change disease. Genetic analyses of NPHS2, PLCE1, and WT1 were done in 4 patients and 2 of them had WT1 mutation. Among 3 patients with congenital nephrotic syndrome, 1 patient was diagnosed as congenital nephrotic syndrome of Finnish type and the other 2 patients were diagnosed as Denys-Drash syndrome. All of the patients with congenital nephrotic syndrome died due to sepsis. Among 4 patients with infantile nephrotic syndrome, 2 patients died and 1 had remission, another patient progressed to end stage renal disease. Conclusion : Most of nephrotic syndrome manifesting in the first year was hereditary renal disease. Patients with nephrotic syndrome manifesting in the 3 month of life had poorer prognosis and needed more aggressive management including early dialysis and renal transplantation might be considered compared with infantile nephrotic syndrome. Further genotype-phenotype correlation studies are needed.

금속산화물을 첨가한 ZnGa2O4 : Mn 형광체막의 CL 특성 향상

조성희,유재수,이종덕 ( Sung Hee Cho,Jae Soo Yoo,Jong Duk Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

전계방출 디스플레이용 형광체의 제반특성

조성희,강상원,유재수 ( Sung Hee Cho,Sang Won Kang,Jae Soo Yoo ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.1

당뇨 생쥐에서 대황 추출물 및 정제환의 혈당과 지질 상태 개선 효과

조성희(Cho Sung-Hee),박소영(Park So-Young),최상원(Choi Sang-Won) 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.6

The objectives of this study were to investigate the antihyperglycemic and hypolipidmic effects of sea oak (Eisenia bicyclis, EB) in the diabetic state and to examine the appropriateness of formulated EB pill for the effects. The various test materials obtained from EB were included in the experimental diets with 15% fat/0.5% cholesterol and fed to streptozotocin-induced diabetic mice weighing 35.0 ± 0.7 g for three weeks but not in the control diet having the same composition. The test materials were EB dry powder, water and ethanol extracts, viscozyme-treated EB water extract (EB enzyme-TR) and formulated pill containing dry powders of the EB, two kinds of seaweed, black soybean, sesame, onion and garlic. BG was measured during feeding period and serum insulin, lipids and thiobarbituric acid reactive substances (TBARS) and intestinal disaccharidase activities were measured at the end of the three weeks of the feeding. BG increase was lower in the EB enzyme-TR group after 10 days of the experimental diet but lower in EB pill group after 15 days compared with the control group. Serum insulin levels were higher in the EB enzyme-TR and EB pill groups. Intestinal maltase but not sucrase activity was higher in EB enzyme-TR fed group than the control group. Serum levels of total cholesterol and triglyceride were reduced by the EB enzyme-TR and EB pill compared with the control diet. HDL-/total cholesterol was increased by all EB test materials. Serum TBARS levels were lower in the EB ethanol extract and EB pill groups than in the control group and tended to be lower in the other EB groups. It is concluded that the EB enzyme-TR is the best among the EB preparations to be utilized as a functional component for improving blood glucose and lipid profile in diabetic subjects in the future. However, the pill containing low level of the EB powder is also regarded as effective and readily usable when formulated with the several other ingredients of the proper composition. (Supported by the RIC Program of MOCIE, Korea). (Korean J Nutr 2008; 41(4): 493 ~ 501)

외현화 장애학생과 일반학생의 심리적 특성 비교 : 메타분석의 활용

조성희(Cho Sung Hee),손승현(Son Seung Hyun),고서연(Ko Seo Yeon),백영선(Paek Young Sun),김미령(Jin Mei ling) 고려대학교 교육문제연구소 2017 敎育問題硏究 Vol.30 No.3

본 연구는 메타분석을 통하여 일반학생을 기준으로 외현화 장애에 속하는 주의력결핍 과잉행동장애(Attention Deficit Hyperactivity Disorder: ADHD), 품행장애(Conduct Disorder: CD), 적대적 반항장애(Oppositional Defiant Disorder: ODD) 학생들의 심리적 특성을 비교하고자 하였다. 심리적 특성의 차이는 주효과로서 평균효과크기, 그리고 조절변수에 따른 평균효과크기의 차이를 포함하였다. 분석대상 논문은 1996년부터 2017년까지의 학위논문 20편, 학술지 논문 27편, 총 47편이었다. 자료의 분석은 CMA 2.0을 활용하였다. 연구 결과, 인지영역에서의 세부변인 중 사고문제가 일반학생과 비교하였을 때 큰 효과크기를 갖는 것으로 나타났다. 정서영역의 경우 ADHD학생의 경우 상대적으로 불안이, CD학생은 우울과 분노, 냉소가 높은 것으로 나타났다. 사회성 영역의 경우 ADHD학생은 일반학생과의 의미있는 차이를 보였다. 문제행동 영역의 경우 세 집단 모두 일반학생과 비교하였을 때 많은 차이가 있는 것으로 나타났다. 특히 비행의 경우 모두 큰 효과크기를 나타내어 일반학생보다 외현화 장애학생들이 더 많은 비행 문제를 일으키는 것으로 해석할 수 있다. ADHD, CD, ODD집단 별로 출판유형, 출판년도, 학교 급 변수를 조절변수로 투입한 결과, ADHD학생의 경우에만 출판유형과 학교 급에서 조절효과를 보였다. 이는 ADHD학생의 심리적 특성이 학술지보다 학위논문에서, 중·고등학생보다 유·초등생에서 일반학생과 더 큰 차이가 나타남을 의미한다. 외현화 장애학생의 중재방안에 대한 시사점을 제안하였다. The purpose of this study was to compare the psychological characteristics of students who have externalizing disorders which include Attention Deficit Hyperactivity Disorder(ADHD), Conduct Disorder(CD), and Oppositional Defiant Disorder(ODD). This study included total of 47 studies which include 20 unpublished theses and 27 journal articles, published between 1996 to 2017. This study used the Comprehensive Meta-Analysis software program to analyze the data. Results showed that, thinking problem variables in the cognitive domain showed large effect size. In the emotional domain, ADHD students showed high Q-value in anxiety and CD students showed high Q-value in depression, anger, and cynicism compared with typical students. Futhermore, in the social domain, ADHD students showed significant differences when compared with typical students. And in the problem behavior domain, all three externalizing disorder groups showed significant differences compared with the typical students. In particular, all three groups showed large effect size in juvenile delinquency which can be interpreted as students who have externalizing disorder created more delinquent problems than typical students. The publication type, publication year, and school level variables were used as moderators for ADHD, CD, and ODD group differences analysis. These results indicated that only ADHD group showed moderator effect in publication type and school level. Finally, implications for externalizing disorder students are discussed.

한국인 총당류 섭취기준 설정

조성희(Cho Sung-Hee),정진은(Chung Chin-Eun),김선희(Kim Sun-Hee),정혜경(Chung Hye-Kyung) 韓國營養學會 2007 Journal of Nutrition and Health Vol.40 No.S

Sugars are a ubiquitous component of our food supply and are consumed as a naturally occurring component of many foods and as additions to foods during processing, preparation, or at the table. Most fruits and dairy products are high in sugars and thus naturally occurring sugars are consumed as part of a healthy diet. Some countries developed recommended daily intake figures (daily values: DVs or guideline daily amounts: GDA) for nutrients, and some countries, but not most have developed DV/GDA for total sugars. Dietary Reference Intakes for Koreans established by the Korean Nutrition Society in 2005, did not include the reference values for total sugar or added sugar. The committee on Dietary Reference Intakes for sugar was constituted in 2006 and discussed whether to specify added sugars or total sugar. Although added sugars are not chemically or physiologically different from naturally occurring sugars, many foods and beverages that are major sources of added sugars have lower micronutrient densities compared with foods and beverages that are major sources of naturally occuring sugars. But it was so hard to calculate a dietary intake of added sugar for Korean people, because there was insufficient information about contents of added sugar during processing or preparation of Korean food. Currently Korean or US food labels contain information on total sugars per serving but do not distinguish between sugars naturally present in food and added sugars. Therefore the committee decided to set the reference value for total sugar for Koreans. According to the recommended diet pattern for Koreans suggested by the Korean Nutrition Society, estimated sugar intake from the sugar containing food based on 2,000 kilocalories is 67g or 13% of total energy. Based on the data available on risk of obesity, hypertension, hyperlipidemia, insulin resistance, and metabolic syndrome from the analysis of Korean NHANES, it was insufficient evidence to set a UL for total sugar, but tended to increase serum LDL cholesterol and obesity at over 20-25% of energy from total sugar when consumed with high carbohydrates. Therefore the committee on Dietary Reference Intakes for sugar set the Acceptable Macronutrient Distribution Range for total sugar as 10-20% of total energy intake. (Korean J Nutr 2007; 40 (Suppl) : 3~8)

국내 무용공연을 위한 현행지식재산권법 적용의 한계

조성희(Sung Hee Cho),김은정(Eun Jung Kim) 한국콘텐츠학회 2017 한국콘텐츠학회논문지 Vol.17 No.8

이 연구의 목적은 국내에서 시행 중인 현행 지식재산권법이 무용공연작품을 창작할 때 발생하는 지식재산에 대한 법적용의 한계를 알아보는데 있다. 21세기 이후 무용작품이 현행지적재산 관련법에서 어떻게 보호되고 있으며, 그 법들이 가지는 한계를 문헌을 통해 연구하였다. 본 연구는 먼저, 무용작품에서 발생하는 지식재산을 보호할 가능성이 있는 현행법을 정리하고 둘째, 융·복합 현장에서 이루어지는 안무들을 고찰하였다. 셋째, 앞에서 언급된 지식재산권들이 가지는 한계를 정리하였다. 연구결과 무용지적재산을 보호할 수 있는 지적재산권인 저작권, 특허, 상표법, 영업비밀이 있었다. 연구결과, 공연예술은 융합 콘텐츠를 개발함에 있어서도 대중과 소통할 수 있는 새로운 양식을 개발하지만 새로운 양식은 정작 법으로 그 권리를 완벽히 보호받기 어려움이 있다. 본 연구는 국내 시행중인 지적재산권법 중 오늘날 행해지는 안무 즉 무용창작 과정에서 발생하는 지적재산들을 보호할 수 있는 현행법들을 알아보고, 그 한계를 요약·정리하는데 그 의의가 있다. The purpose of this study is to identify the limits of law on intellectual property generated from dance performance creation. It is based on literature research. It focus the way of dance works protection through current intellectual property laws after 21th century and the limits of them. First, it summarized copyright law, patent, trademark right, and trade secret. Second, it study the choreography of meaning and the process on field of the convergence. At last it summarized the limits of the intellectual property mentioned above. As a result, it is hard to fully protect the right by law whereas performing art create new form of style to communicate with audiences as develop convergence contents. There are significance on this study that summarize the intellectual property law and their limits when they applied to intellectual property from choreography, as a process of dance creation of today.

포스트 코로나 시대의 지역연계 미술 수업 사례 연구

조성희(Cho, Sung Hee) 한국미술교육학회 2021 美術敎育論叢 Vol.35 No.2

본 연구는 코로나 이후의 제한된 상황에서 지역을 주제로 미술과 수업을 실행하고 교육환경의 변화에 따른 미술 수업의 방향을 모색하는 시도이다. 지역과 연계한 16차시의 프로젝트 수업을 통해 학생들은 대부분의 활동을 원격학습으로 랜드마크 모형과 우리 마을의 명소를 알리는 디자인 등의 과제를 수행하였다. 그 결과, 학생들은 네트워크를 통한 창작과 소통이라는 새로운 환경에 적응하며 사회적 거리두기로 요원해진 공동체성을 지향하는 활동을 경험하였다. 원격수업 기반의 지역연계 미술과 수업이 주는 시사점은 다음과 같다. 첫째, 수동적 활동에서 벗어난 온라인 표현 활동의 가능성으로 원격수업의 질적 개선의 방향을 제시하였다. 둘째, 지역과 공동체를 주제로 하는 수업으로 공동체성을 경험하고 실천하는 기회가 되었다. 셋째, 시간과 공간에 제한받지 않는 의사소통으로 교수·학습 방법과 교사의 역할에 대한 재인식의 계기가 되었다. This study is an attempt to implement art classes linked to local subjects in a limited situation after COVID-19, and to seek the direction of art classes according to changes in the educational environment. Through 16 hours of classes, most of the activities were distance learning, and the students performed tasks such as landmark models and design to inform the sights of our community. As a result, the students experienced activities oriented toward community, which had become distant due to social distancing, while adapting to the new environment of creation and communication through networks. The implications of the distance learning-based regional art department classes are as follows. First, it suggested the direction of qualitative improvement of distance learning with the possibility of online expression activities that are not passive activities. Second, it was an opportunity to experience and practice the sense of community through classes with local and community themes. Third, communication that is not limited by time and space served as an opportunity to re-recognize teaching and learning methods and the role of teachers.