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기능성 소화불량증과 기능성 변비를 동시에 호소하는 환자에서 주석산 시사프리드의 증상 개선 효과 및 안전성
양웅석(Ung Suk Yang),조중현(Joong Hyean Cho),구자영(Ja Young Koo),이광웅(Kwang Ung Ri),조성락(Seoung Rak Cho),한상영(Sang Young Han),박희욱(Hee Ug Park),송근암(Geun Am Song),주형준(Hyung Jun Chu),김도하(Do Ha Kim),이준상(Joon Sang Le 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1
N/A Backgrounds/Aims: This study was performed prospectively to evaluate the short - term effect of cisapride tartrate on the frequency and the degree of symptoms in patients with functional dyspepsia and functional constipation. Methods: One-hundred thirty-two patients with a mean age of 44.7 years in men and 43.1 years in women, who presented with symptoms of both functional dyspepsia and functional constipation were recruited, and the frequency and the degree of symptoms corresponding to functional dyspepsia and functional constipation were assessed by an interview in 10 hospitals respectively. In an open, multicenter trial, 132 patients received 10 mg of cisapride tartrate three times a day (TID) for 8 weeks. Patients wrote a defecation diary for 8 weeks and checked symptom scores, which represented the degree of symptoms of dyspepsia and constipation, at the 4th and 8th week. Results: The frequently reported symptoms of functional dyspepsia were epigastric fullness (2.34 0.80), bloating (2.05 0.82), early saety (1.67 0.99), anorexia (1.04 0.95) and nausea (0.94 0.93). The mean defecation frequency per week was 3.07 2.35 and patients showed subjective symptom scores as follows; 97.0 25.26 % in the rate of sense of incomplete evacuation, 1.85 0.73 in the hardness of stool and 1.62 0.57 in difficulty to pass stool. After adminstration of cisapride tartrate in the case of functional dyspepsia, 66.1% of patients at the 4th week and 81.5 % of patients at the 8th week showed good or excellent improvements. In the case of functional constipation, 82.7%of patients also showed good or excellent improvements. Overall improvements of symptoms in both functional dyspepsia and functional constipation were 78.2% at the 8th week. Conclusion: Cisapride tartrate reduced the frequency and the degree of symptoms in functional dyspepsia and functional constipation without significant adverse effects.(Korean Journal of Gastrointestinal Motility 2001;7:36-46)
위장관 출혈을 동반한 원발성 양성 소장 간질종양 1 예
서길동(Kil Dong Seo),김명준(Myung Jun Kim),김수형(Su Hyung Kim),김일두(Il Doo Kim),허정호(Jeong Ho Heo),이채원(Chae Won Lee),박상제(Sang Je Park),김상현(Sang Hyun Kim),조성락(Sung Rak Cho) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
The origin and clinical behavior of gastrointestinal stromal tumors (GISTs) have been a source of recent speculation and controversy. GIST has been applied to mesenchymal tumors that represent neither their typical leiomyomas nor schwannomas. GISTs are spindle cell tumors occurring mainly in adults with 5-year survivals in 50-56% and 10-year survivals in 35-43%. Because of its indolent and slow-growing nature, it is difficult to define it as malignancy. We report a case of benign stromal tumor of the proximal jejunum presenting melena in a 32-year-old male. Small bowel series and computed tomography of the abdomen revealed submucosal tumor in the proximal jejunum. Histological studies on the surgical resection specimen revealed a gastrointestinal stromal tumor of a benign type with no evidence of metastasis. The patient was treated with local excision of the tumor and is now in a favorable state. (Korean J Gastroenterol 2001;38:371-375)
위장관의 비호지킨 림프종 환자에서 발생한 Isospora Belli 1 예
김민성,박봉태,이일수,박종호,이인상,장도현,조성락,문취용,강종득,김종한,최호수,이채원 대한내과학회 1996 대한내과학회지 Vol.51 No.1
The coccidian parasite Isospora belli causes human intestinal disease. It have been associated with immunodeficent states. Recently Isospora belli has also been recognized as an opportunistic protozoan pathogen in patients with the acquired immunodeficiency syndrome(AIDS). Most case are self-limited, with spontaneous resolution occuring in several weeks. However, in patients with AIDS or other immunocompromise infections are not self-limited but rather may resemble cryptosporidiosis with chronic, profuse watery diarrhea. Recently we experienced a case of isosporiasis in non-Hodgkin's lymphoma patient presenting as diarrhea and weight loss. The patient was treated with trimethoprim-sulfamethoxazole with clinical improvement. So we report this case with a literature review.
십이지장의 악성 선암 및 폐색을 동반한 Peutz-Jeghers syndrome 1예
김형진,이경일,허정호,한상길,배용목,황영훈,조성락,손신 대한내과학회 1999 대한내과학회지 Vol.56 No.3
Peutz-Jeghers syndrome is a rare autosomal dominant disorder defined by harmatomatous polyps of the gastrointestinal tracts and the occurrence of melanin spots on the lips(oral mucosa), hands and feet. This syndrome is associated with a variety of gastrointestinal and extraintestinal neoplasms, both benign and malignant. A 28-year old male was admitted to our hospital with abdominal pain and nausea for two months. He had melanin spots involving his lips, buccal mucosa, hands and feet. A small bowel series showed luminal obstruction at the forth portion of the duodenum. And abdominal CT scan showed target-like mass suggesting intussusception on the small bowel. On laparotomy, there was an annular constricting mass adherent to retroperitoneum with metastasis to preaortic lymph nodes. Palliative duodeno-jejunostomy was performed. The histologic finding disclosed signet-ring cell type adenocarcinoma.