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고지방식이 비만마우스에서 월비가출탕(越婢加朮湯)이 식이효율과 내장지방에 미치는 영향
안정란 ( Jeong Ran An ),강연경 ( Yeon Kyeong Kang ),장동호 ( Dong Ho Chang ),이인선 ( In Seon Lee ),신순식 ( Soon Shik Shin ),정해경 ( Hae Gyeong Jeong ),이희영 ( Hee Young Lee ),이혜림 ( Hye Rim Lee ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.1
Objectives: This study was undertaken to verify the effects of Wolbigachul-tang 1(WBCEx1) on obesity using high fat diet-induced male mice and to investigate the molecular mechanisms involved. Methods: 8-week old C57BL/6 mice were divided into 5 groups; lean control, obese control, WBCEx1, 2, 3. After mice were treated with WBCE x1(water extract), 2(30% ethanol extract), 3(water extract; Ephedra sinica Stapf., Gypsum fibrosum) for 12 weeks, body weight gain, feeding efficiency ratio, plasma lipid and glucose metabolism, the messenger RNA(mRNA) expression of peroxisome proliferator activated receptor(PPAR)α target genes were measured. In addition, PPARα target gene expression was examined in liver, white adipose tissue and skeletal muscle. Results :1. WBCEx1-treated mice had significantly lower body weight gain and feeding efficiency ratio. 2. Consistent with the effects on body weight gain, WBCEx1 decreased the weights of epididymal and retroperitoneal white adipose tissue, inguinal subcutaneous adipose tissue, and brown adipose tissue. 3. WBCEx1 significantly decreased plasma triglyceride and total cholesterol levels. 4. The size of adipocytes were significantly decreased by WBCEx1, whereas the adipocyte number per unit area was increased. Hepatic lipid accumulation was decreased by WBCEx1. 5. WBCEx1 did not affect the mRNA expression of PPARα target genes in liver, adipose tissue, and skeletal muscle. 6. Plasma asparate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN) and creatine concentrations were in the physiological range. Liver and kidney weights were significantly lower following WBCEx treatment compared with obese controls, indicating that WBCEx does not show any toxic effects on liver and kidney. Conclusions: These results suggest that WBCEx1-induced body weight reduction is associated with appetite control and mediated by a mechanism other than the activation of PPARα.
GGEx16 Reduces Blood Lipid Levels and Adipose Tissues in High Fat Diet Induced Obese Mice
Pei-Chin Tsung,Hae-Gyeong Jeong(정해경),Su-Mi Park,Hee-Young Lee,Juran Ha,Yeonhee Hong,Seolwha Choi,Dongmin Park,Ki-Hyeon Yoon,Yang-Sam Jung,Michung Yoon,Soon-Shik Shin 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.2
고지방식이 마우스 비만모델에서 발효대두파우더의 체중증가량 변화와 지방간 개선
총배금,이희영,이혜림,정해경,윤연미,윤미정,박선동,신순식,Tsung, Pei-Chin,Lee, Hee-Young,Lee, Hye-Rim,Jeong, Hae-Gyeong,Yin, Yuan-Mi,Yoon, Mi-Chung,Park, Sun-Dong,Shin, Soon-Shik 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2
Objectives : We investigated the effects of fermented soybean(FSOB) on body weight and examined whether hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, FSOB(1), (2) and (3). After mice were treated with FSOB for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Results : 1. Compared with controls, FSOB-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in FSOB(3) and FSOB(1). 2. Compared with controls, FSOB-treated mice had lower feeding efficiency ratio and blood plasma leptin levels, the magnitude of which was prominent in FSOB(3). 3. Compared with controls, FSOB-treated mice had lower blood plasma total cholesterol and LDL-cholesterol levels. 4. Blood plasma AST and ALT concentrations were not changed by FSOB, indicating FSOB do not show any toxic effects. 5. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by FSOB, whereas the adipocyte number per unit area was significantly increased, suggesting that FSOB decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by FSOB. Conclusions : These results demonstrate that FSOB effectively reduces body weight gain, feeding efficiency ratio, blood plasma leptin level and improves hepatic lipid accumulation.
GSEx4 Modulates White Adipose Tissues in High Fat Diet induced Obese Mice
Pei-Chin Tsung,Ki-Hyeon Yoon,Yang-Sam Jung,Hee-Young Lee,Hae-Gyeong Jeong(정해경),Su-Mi Park,Juran Ha,Yeonhee Hong,Seolwha Choi,Dongmin Park,Michung Yoon,Gyeong-Cheol Kim,Soon-Shik Shin 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.-
소풍순기원(疏風順氣元)이 고지방식이 비만 대사증후군 병태 흰쥐에 미치는 효과
김보경 ( Bo Kyung Kim ),오영진 ( Young Jin Oh ),천영호 ( Young Ho Chun ),하지원 ( Ji Won Ha ),이회영 ( Hee Young Lee ),정해경 ( Hae Gyeong Jeong ),신순식 ( Soon Shik Shin ),이상언 ( Sang Eon Lee ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.4
Objectives: We investigated the effects of Sopungsungi-won(Shufengshunqiyuan) (SSEx1, SSEx2) on the metabolic syndrome in high-fat diet induced obese mice. Methods: 8 weeks old, high fat diet induced obese male mice were divided into 4 groups: C57BL/6 lean control, obese vehicle control, SSEx1, SSEx2. After mice were treated with SSEx1, SSEx2 for 12 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin, insulin, glucose and lipid levels. We also observe the morphology and count for the numbers of Adipocyte and evaluate the weight of organs and it`s function. Results: 1. Compared to Obese Control Group, SSEx1 gained significantly lower body weight and showed lower Feeding Efficiency Ratio. 2. Compared to Obese Control Group, SSEx1 showed lower weights of epididymal adipose tissue, troperitoneal adipose tissue, inguinal adipose tissue, brown adipose tissue. SSEx2 showed higher weights of epididymal adipose tissue, troperitoneal adipose tissue, inguinal adipose tissue, brown adipose tissue. 3. Compared to Obese Control Group, the size of adipocytes was significantly decreased by SSEx1, whereas the number of adipocites per unit was significantly increased. Hepatic lipid accumulation was decreased significantly by SSEx1. 4. Concerning the weights of Liver, Heart, Spleen, Kidney and Pancreas, SSEx1, SSEx2 showed little differences with those of Lean Control, Obese Control. 5. Compared to Obese Control Group, SSEX1, SSEx2 showed lower level of plasma triglyceride, but SSEx1 had significance only. SSEx1, SSEx2 showed little lower level of plasma HDL-cholesterol, LDL-cholesterol, total cholesterol, but had no significances. 6. Concerning the levels of plasma glucose, insulin and leptin, SSEx1 and SSEx2 showed littele changes with those of Lean Control, Obese Control. 7. The leves of Plasma AST, AST, ALT, free fatty acid, BUN, creatinine were in the physiological range at 4 groups all;Lean Control, Obese Control, SSEx1, SSEx2. Conclusions: These results showed SSEx1 can be used as therapeutic agent for Obesity and metabolic syndrome caused by long-period high fat diet.