유전자 조작 , 균주분리 Yeast Thioredoxin System 의 발현 , 정제 및 특성조사

정진숙,김명희,김강화 한국미생물생명공학회 1998 한국미생물·생명공학회지 Vol.26 No.6

탄광부의 폐장내 Telomerase 활성

정진숙,남혜윤,김경아,임영,안병용 대한직업환경의학회 2002 대한직업환경의학회지 Vol.14 No.4

Objective: We measured the activity of telomerase in coal workers lung tissue and found a significant increase in telomerase activity compared to the control group. Pneumoconiosis has the characteristics of fibroblast proliferation and the accumulation of collagen, thus finally causing the pathologic changes, which lead to the irreversible and progressive fibrosis of the lungs. We hypothesized that this cellular proliferation causing irreversible fibrosis may induce some elongation of the life cycle in the chromosomes and lead to further cellular immortalization. Method: 8 postmortem (within 24 hours) pneumoconiotic cases were examined and their telomerase activity was compared with that of the autopsied lungs of lung cancer patients and of accident victims without any respiratory diseases. Using the extracted ribo-nucleoprotein from pneumoconiotic nodules, telomeric repeat amplification assay (TRAP) was done. Result: The pneumoconiotic lungs showed strong telomerase activity, similar to that of the lung cancer patients, while the control group showed no such activity. Conclusion: Based on the results of this study, we found that coal dust-induced cellular proliferation affects telomerase-activity clinically. 목적: 석탄분진에 의한 탄광부 진폐증에서 폐의 염증 또는 섬유모세포의 증식에 의한 telomerase의 활성을 알아보고자 하였다. 방법: 20년 이상 광부 작업력이 있는 탄광부 8명과 폐종양 8명, 대조군으로 교통사고에 의한 사망 6명의 부검을 통한 폐장내 telomerase 활성을 telomeric repeat amplication protocol(TRAP) 분석 방법을 이용하여 측정하였다. 결과: 탄광부 부검폐조직 내의 telomerase 활성도가 대조군에 비하여 유의하게 증가되었으며 이는 폐종양군과 같은 수준이었다. 결론: 탄광부 진폐증에서 폐장내 과도한 세포증식이 telomerase 활성을 증가시키며, 이에 관한 기전에 대해 보다 폭넓은 연구가 필요하다.

신소설 『경포대(鏡浦臺)』에 나타난 지역의 갈등과 여성 인물의 신분 상승 욕망

정진숙 강원대학교 인문과학연구소 2023 인문과학연구 Vol.- No.79

The fact that Gyeongpodae (1926) was used as the title of the new novel is closely related to the context of the time when Joseon’s landscape was newly discovered through discovery of landscapes, scenic spots, cruises, and inspections. In the new novel, the background space is the place where life takes place, and the cases of scenic spots or arract views that discover new landscapes in the modern era has increased as the adoption of novel’s title. Gyeongpodae, a space with historical value and meaning, has changed beyond time and space, and has been recognized as a beautiful place by people from before to the present. Gyeongpodae reveals the desire for class rise of the status that resists material and convention, centering on the female protagonist who leads the development of the narrative, and is biased toward a family novel that shows the unreasonable social reality of the wife-in-law system, so it is necessary to discuss whether the character of the characters at the time has regionality. The protagonist of the novel is a woman who has not escaped from Gyeongpodae in Gangneung and re-enters to Seoul, Gwangneung, and Seoul beyond Daegwallyeong, the border between Seoul and Gangneung, which is close to the female narrative where the mother-in-law finds her rights. Gangneung, set in Gyeongpodae, has a large-scale reclamation along the coast during colony of Japanese Imperialism, with new residences and spaces formed, and Koreans are gradually being pushed to the surroundings as migrant Japanese settle down. The expansion of the continent due to the expansion of farmland in Gyeongpodae, Gangneung, outwardly advocated the modernization of Joseon, but appeared as a space for Japan’s exploitation policy. This article focuses on the narrative of the new novel Gyeongpodae, examines the bibliography of the work, the narrative paragraph, and the conflict between the characters in Gangneung and Seoul, and analyzes what the desire and nomination of female characters means.

더 더워져서는 안되는 전주

정진숙 열린전북 2013 열린전북 Vol.166 No.-

학교생활 부적응 아동의 자아존중감 향상과 불안․우울 감소를 위한 미술치료

정진숙,김갑숙 한국예술심리치료학회 2008 예술심리치료연구 Vol.4 No.1

This study was to evaluate the effects of an art therapy on the children who are maladaptive at school and have problems like low self-esteem, anxiety, and depression. The subjects were treated by the art therapy consisting of 20 sessions in total, 2 session a week, and each session lasted 60minutes. Research tools used for the study are as follows: First, pre-test and post-test to estimate comparatively their level of self-esteem, anxiety, and depression; next, Draw-a-Person(DAP) and Kinetic School Drawing(KSD), Kinetic Family Drawing(KFD) for a qualitative analysis. The results of this study are as follows; First, Art Therapy Program has an effect on improving self-esteem. Second, Art Therapy Program has an effect on reducing Anxiety and Depression.

패킹하우스 중심의 감귤 브랜드마케팅 및 포장디자인 연구

정진숙,최광훈 한국패키지디자인학회 2002 상품문화디자인학연구 Vol.12 No.-

Developing living standard of people by industrial advance, mind structure and preferences of consumers are getting diverse and complex. By unbalanced market situation between production and consumption there are emerging a consumer leading market, in which consumers take initiatives to choose various products of many producers. So, the importance of brand-packing design is getting highlightened. In the position of consumers, they can have plenty of opportunities to select a brand product among many brands of products. In the opposite position, suppliers should make their diverse products compete with each other in more severe market situation than ever. However, both consumers and suppliers agree to say that brand is the only hope to attarct consumers in such competitive situation. Therefore, enterprises and local governments concern importantly as their one of survival strategies how strong brands they have. Development of mandalin brand focusing on packing house is recommended as strategy of differentiated quality of mandalin industry in danger. The first stage of the strategy is to advertise the image of Jeju mandalin and increase preferences among consumers. And the second stage is to make the mandalin brand competitive in globla market. A key point for success of the mandalin brand focusing on pakcing house is to respond for requirements of consumers, for which it is essential to produce high quality mandalin and maintain its quality in the process of circulation. It is required to develop the quality in the stage of production for strengthening competitiveness of mandalin. And also, prohibition of circulating inferior fruits and refraining from harvesting unrippened fruits, and development of packing design for raising product value are compusory tasks in the stage of circulation. So, new policies should be introduced to circulate the high quality mandalin, like reducing numbers of packing houses, which are more thatn 900, developing capabilities of select-packing machine, and introduction of big packing house system to prevent from abitrary sorting by each producers. Moreover, we need to consider new marketing strategies, such as production plan for high quality produts rather than stressing brands by production sites and change of brands focusing on packing house taking care of selecting, packing and circulation. So, this research tries for consumers to recognize mandalin brands more widely and to propose brand packing design by managers of packing houses. This paper intends for mandalin brands to be recognized systematically as a confident brand in domestic market and a successful brand in global market by planned producing, planned circulation, and product-value relevant to its brand.

아동의 정서적 학대에 따른 좋아하는 날씨(FKW)그림 반응특성 연구

정진숙,김갑숙 한국미술치료학회 2012 美術治療硏究 Vol.19 No.4

The aim of this study is to develop valid and reliable assessment criteria for Favorite Kind of Weather (FKW)drawing to use a projective diagnostic technique for the possible detection of child abuse. The subjects chosen for this study were 295 children between the ages of ten to sixteen from various temporary residences such as child protection shelters or institutions. 282 other children also between grade three and grade nine from families with no known history of child abuse were randomly chosen totaling 577 children. The assessment instruments included were FKW drawing, Child Abuse Experience Scale. To gauge the reliability of assessment criteria, Cronbach's alpha test was used to determine the internal consistency. To measure reliability among raters, inter-rater reliability and intra-rater reliability test methods were used. Person’s correlation analysis, Chi square, and Discriminant analysis were used to verify the validity of assessment criteria. The results of this study were as follows. First, the inter- rater reliability, intra-rater reliability, and question item reliability test were followed. The inter-rater consistency among three raters ranged from 94.0% to 95.9%, the intra-rater consistency was 97.0% and the internal consistency for the form items, as expressed by Cronbach’s alpha, was computed .721 and for the content items was .632. Second, the significant correlation between the two was found by showing .15~.52 between emotional abuse and FKW drawing. In explaining the emotional abuse, 62% was shown in explaining the abuse in the variables of the FKW drawing. The differentiating power of variable was 89.6%. For the non-abused group, 88.7% is expected and 91.3% for the abused group. In conclusion, these assessment criteria were proved to serve as a valid and reliable diagnostic tool to recognize possible child emotional abuse. 본 연구는 ‘좋아하는 날씨(FKW)’그림이 학대를 예측, 변별할 수 있는 투사검사인지를 알아보고자 평가기준을 개발하고, 신뢰도와 타당도를 검증하였다. 연구의 대상은 초등학교 3학년부터 중학교 3학년까지 총 577명(시설아동 295명, 일반아동 282명)의 아동을 층화표집 하였다. 측정도구는 FKW그림과 아동학대경험척도이다. 자료 분석은 평가기준의 신뢰도는 문항내적일치도(Cronbach‘s α)에 의한 신뢰도 검증과 평가자간 일치도와 평가자내 일치도를 구하였고, 타당도 분석을 위하여 Pearson상관분석, 교차분석, 판별분석을 실시하였다. 연구결과는 첫째, 평가자간 일치도 94.0%- 95.8%, 평가자내 일치도 97.0%로 나타났으며, 평가항목의 신뢰도는 형식요인 Cronbach's α=.721, 내용요인 .632로 나타났다. 둘째, 정서적 학대와 FKW그림과의 상관관계는 .15∼.52로 나타났다. 정서적 학대를 비학대와 학대집단으로 분류하여 FKW그림의 반응특성의 차이를 살펴본 결과, FKW그림의 형태요인, 내용요인 모두 차이가 있는 것으로 나타났다. FKW그림 변인들이 정서적 학대를 설명하는 정도는 62%이고, 이 변인들의 판별력은 89.6%이었으며, 비학대집단은 88.7%, 학대집단은 91.3%를 예측하고 있다. 따라서 FKW그림 평가기준은 신뢰도와 타당도를 확보하여 정서적 학대 변별도구로서 활용할 수 있음을 입증하였다.

포스터발표 : Diethylnitrosamine 유도 간암과 발생 중 S-1 투여군의 유전자 발현 비교 후 돌출된 후보유전자의 백서 간암 및 인체 간암에서의 발현 연구

정진숙,백양현,이성욱,한상영 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3(S)

한국인 혈액의 정상치에 관하여 -20∼30세 정 상인-

정진숙,설미영,김순호 대한병리학회 1984 Journal of Pathology and Translational Medicine Vol.18 No.1

다문화가정아동의 학교생활적응을 위한 덕목 연계 미술치료프로그램 개발

정진숙 한국예술심리치료학회 2016 예술심리치료연구 Vol.12 No.2

본 연구의 목적은 학교생활적응을 위한 덕목 연계 미술치료프로그램을 개발하고, 다문화가정아동을 대상으로 그 효과를 검증하고자 하는 것이다. 연구대상은 B지역 다문화가정센터의 다문화가정아동으로, 실험집단 6명, 통제집단 6명으로 구성하였다. 프로그램은 주 1회 90분씩, 총 10회기 실시되었다. 자료처리는 SPSS WIN Program(version.21)을 이용하여 프로그램과정에서의 학교생활적응검사를 사전, 사후로 실시하고, 공변량분석(ANCOVA)으로 검증하였으며, 아동들의 행동특성변화는 회기별로 관찰하여 사전, 사후로 비교분석하였다. 본 연구의 목적을 바탕으로 연구결과를 요약하면 다음과 같다. 첫째, 덕목 연계 미술치료프로그램은 다문화가정아동의 학교생활적응 향상에 효과가 있는 것으로 나타났다. 학교생활적응 점수가 실험집단에서 유의미하게 향상되었으며 그 효과가 지속되었다. 둘째, 프로그램 회기과정에서 학교생활적응 향상의 행동변화특성을 볼 수 있었다. 이러한 연구 결과 덕목 연계 미술치료프로그램은 다문화가정아동의 학교생활적응 향상에 효과적이라고 할 수 있다. This study was purposed to develop virtues association art therapy program for multicultural children’s school adjustment and to prove its effect. The subject of the study was 12 children taught in a multicultural support center of B city. They were unintentionally classified into twe groups: an experimental group of 6 children and a control group of 6 children. The therapy program was performed a total of 10 sessions with 90 minutes each week from July 2014 to October 2014. This research executed school life adjustment test and child’s behavioristic observation. The data of before-and-after test was analyzed by SPSS WIN Program(version 2.0) and verified with ANCOVA. Study results were as follows. Firstly, virtues association art therapy program positively influenced into multicultural children’s school adjustment. Secondly, the behavioral change pattern of multicultural family children by virtue association art therapy program showed reciprocal action such as regarding and respecting others compared to the passive and non-cooperative attitude of before the program application. Thus, the study results that the virtue associated program is positively influenced into multicultural children’s school life. The significance of the study is meaningful in proving the possibility of usability of the art therapy association with the virtue.