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Gore - Tex(TM) membrane 과 COLLACOTE(R) 를 이용한 골유도 재생술의 조직학적 비교 연구
장창덕(Chang Dug Jang),김태규(Tae Kyu Kim),김철훈(Cheol Hun Kim) 대한악안면성형재건외과학회 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.1
The principle of guided tissue regeneration (GTR), as applied to bone healing is based on the prevention of connective tissue from entering the bony defect during the healing phase. This allows the slower bone producing cells to migrate into and reproduce bone within the defect. GTR has demonstrated a level of success in regenerating bone defect. Several types of membrane barrier have been utilized to apply this principle in bone regeneration, The purpose of this study was to evaluate whether improved bone regeneration can be achieved with different membrane barriers (Gore-TexTM membrane, COLLACOTER). In the 10 NewZealand white rabbits, full-thickness bone defects on three sites of each rabbit calvaria were made. Experimental group 1 was covered with COLLACOTER, and group 2 was covered with Core-Tex TM membrane. Macroscopic, microscopic examinations were made serially on 1, 2, 3, 6, 12 weeks after operation. The results were as follows : 1. Macroscopically, both of experimental group 1, 2 were filled with bone-like mass but the defects of experimental group 1 disclosed markedly thinner than the original bone. 2. Microscopically, the defect of experimental group 1, 2 was filled with bony trabeculae without-infection and adverse reaction. But multinucleated giant cell infiltration around COLLACOTER was seen till 6th week. 3. Resorption of COLLACOTER started from 3rd week and it was completely resorped on the 12th week.
가토에서 러버댐을 이용한 골결손부의 골조직 유도 재생술에 관한 실험적 연구
장창덕,황희성,신상훈,Jang, Chang-Dug,Whang, Hie-Seong,Shin, Sang-Hun 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.2
The principle of guided tissue regeneration (GTR), as applied to bone healing, is based on the prevention of connective tissue from entering the bony defect during the healing phase. This allows the slower bone producing cells to migrate into and reproduce bone within the defect. The principle of guided tissue regeneration has demonstrated a level of success in regenerating bone defect. Several types of membrane barrier, each one with distinct properties, have been utilized to apply this principle in bone regeneration. The purpose of this study is to introduce and discuss the attributes of rubber dam as a barrier membrane and evaluate whether improved bone regeneration can be achieved by GTR using rubber dam. In the 15 New Zealand white rabbits, full-thickness bone defects on three sites of each rabbit calvaria were made. Non membrane group served as a control and experimental group 1 was covered with rubber dam and group 2 covered with Gore-Tex$^{TM}$ membrane. Macroscopic, radiographic, microscopic examinations were made serially on 1, 2, 3, 6, 12 weeks after operation. The results were as follows: 1. Macroscopically, the control site was collapsed and filled with connective tissue throughout the experimental period. But the defects of experimental groups 1 and 2 were filled with bone-like mass and showed the hard consistency on palpation. 2. Radiographically, the early new bone formation appeared similarly from the host bone in groups 1 and 2. 3. Microscopically, there were much connective tissue at the central part of control site but the defect of group 1 and 2 was filled with the mature bony trabeculae on the 12th week. This results suggest that rubber dam can be effectively used as a barrier membrane for guided bone regeneration.
Gore-Tex<sup>TM</sup>membrane과 COLLACOTE<sup>®</sup>를 이용한 골유도 재생술의 조직학적 비교 연구
김태규,장창덕,김철훈,Kim, Tae-Kyu,Jang, Chang-Dug,Kim, Cheol-Hun 대한악안면성형재건외과학회 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.1
The principle of guided tissue regeneration (GTR), as applied to bone healing, is based on the prevention of connective tissue from entering the bony defect during the healing phase. This allows the slower bone producing cells to migrate into and reproduce bone within the defect. GTR has demonstrated a level of success in regenerating bone defect. Several types of membrane barrier have been utilized to apply this principle in bone regeneration. The purpose of this study was to evaluate whether improved bone regeneration can be achieved with different membrane barriers ($Gore-Tex^{TM}$membrane, $COLLACOTE^{(R)}$). In the 10 NewZealand white rabbits, full-thickness bone defects on three sites of each rabbit calvaria were made. Experimental group 1 was covered with $COLLACOTE^{(R)}$, and group 2 was covered with $Gore-Tex^{TM}$membrane. Macroscopic, microscopic examinations were made serially on 1, 2, 3, 6, 12 weeks after operation. The results were as follows : 1. Macroscopically, both of experimental group 1, 2 were filled with bone-like mass but the defects of experimental group 1 disclosed markedly thinner than the original bone. 2. Microscopically, the defect of experimental group 1, 2 was filled with bony trabeculae without infection and adverse reaction. But multinucleated giant cell infiltration around $COLLACOTE^{(R)}$ was seen till 6th week. 3. Resorption of $COLLACOTE^{(R)}$ started from 3rd week and it was completely resorped on the 12th week.
장창덕,이용재,이정석 東義大學校 産業技術開發硏究所 1999 産業技術硏究誌 Vol.13 No.-
In order to remove minority carries of the base region at changing signal in conventional bipolar logic circuit, we made transistor which is created by NPN transistor shortened buried layer under the Base region and PNP transistor which is merged in base, epi layer and substrate and designed the Ring-Oscillator for measuring transmission time-delay per gate as well. The structure of logic cell consists of the vertical NPN transistor and merged PNP transistor. For getting data of device simulation, we extracted characteristic parameter with analyzing current-voltage characteristic of vertical NPN transistor and merged PNP transistor. In the result, we found that carriers which are coming into intrinsic base from emitter and the portion of edge are relatively a lot, so those make base currents a lot and gain is low with a few of collector currents because of cutting the buried layer of collector a half at being relatively small emitter are of NPN transistor comparing of conventional junction area. Merged PNP transistor's currents are low because base width is wide and the difference of emitters density and base's density is small. We get 200mV amplitude of logic voltage, 211nS the minimum of transmission delay-time, and 7.26nS the minimum of transmission delay-time per gate in AC characterist output of Ring-Oscillator connected gate.