두경부종양환자에서 시행한 상부위장관검사의 유용성

장지영(Ji Young Jang),조문준(Moon June Cho),김준상(Jun Sang Kim),김병국(Byoung Kook Kim),정현용(Hyun Yong Jeong),김재성(Jae Sung Kim) 대한두경부종양학회 1999 대한두경부 종양학회지 Vol.15 No.2

Background and Objectives: Multiple primary tumors of the upper aerodigestive tract are not unusual. We examined head and neck cancer patients to discover the presence of second primary cancer in their upper gastrointestinal tract, using esophagogastroscopy. Materials and Methods: Endoscopic examination of the upper gastrointestinal tract was performed on 51 patients whose head and neck cancers were treated at department of therapeutic radiology from August 1996 to April 1999. Two of all patients had been studied by barium swallowing study. In 51 patients, twenty-four had a primary tumor in the larynx, 8 in the oropharynx, 6 in the nasopharynx, 6 in the oral cavity, 6 in the hypopharynx, and 1 in the nasal cavity. Endoscopically pathologic lesions were biopsied. In control group, endoscopy was performed on 1097 patients who didn't complain any symptoms. Results: Endoscopy showed early malignant lesions in 4 cases(7.7%). Histology of esophageal cancers showed squamous cell carcinoma. Malignant lesions of stomach in 2 cases were histologically identified as adenocarcinoma. Two esophageal cancers occurred in patients whose primary lesions had oropharynx and hypopharynx. Two cases of gastric cancer were also accompanied by oropharynx and hypopharynx. The incidence of second primary cancer was 2 in oropharynx and 2 in hypopharynx. In all cases, second primary cancers were found simultaneously. In control group, 9(0.8%) of 1097 patients were confirmed as early esophageal and gastric cancers. Conclusion: The majority of esophageal and gastric cancer detected by endoscopy were early stage in both head and neck cancer and control group. The incidence of esophageal and gastric cancer of head and neck cancer patients was 10 times as high as that of control group. Although followup period was short, all second primary cancers were detected simultaneously. We would recommend that endoscopic evaluation be included in the workup and followup of all patients with newly diagnosed head and neck cancer.

냉난방 동시운전이 가능한 공랭식 히트펌프의 최적제어에 관한 연구

장지영(Ji Young Jang),사용철(Yong Cheol Sa),김병순(Byung Sun Kim),배흥희(Heung Hee Bae),하만영(Man Yeong Ha) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-3

습도센서를 이용한 VRF 시스템의 고효율 쾌적 부하 대응 운전에 관한 연구

장지영(Ji Young Jang),송치우(Chi Woo Song),윤필현(Phil Hyun Yoon),사용철(Yong Cheol Sa) 대한설비공학회 2017 대한설비공학회 학술발표대회논문집 Vol.2017 No.6

With the increase of energy saving for HVAC in building, the use of VRF system increases gradually. A humidity sensor was applied to a VRF system that can be operated by a single outdoor unit with multi indoor unit. The outdoor temperature, indoor humidity, temperature difference between the set and room temperature were using into optimized control logic. As a test result, the required cooling load decreased as the humidity was lower during cooling operation and the maximum efficiency improvement of about 36% was obtained in the low humidity region at the room temperature condition of 27℃. Also, considering the dew point temperature according to the outdoor temperature and the humidity during heating operation, an automatic frost delay control logic was established and the delay effect of about 12% was obtained at frost test condition

인체 위해 추정을 위한 디젤 배출 입자의 용량-반응 평가

양지연(Ji-Yeon Yang),장지영(Ji-Young Jang),이용진(Yong-Jin Lee),김수환(Soo-Hwan Kim),신동천(Dong-Chun Shin),임영욱(Young-Wook Lim) 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.5

장갑강 아크용접부의 방탄시험 대체검증 표준 제정에 대한 연구

김용(Yong Kim),오민철(Min Chul Oh),장지영(Ji Young Jang),김도희(Do Hui Kim) 대한용접·접합학회 2024 대한용접·접합학회지 Vol.42 No.1

The final goal of this study is to secure the basis for establishing a domestic test standard such that the H-plate ballistic test for weld verification required by TACOM Drawing 12479550 can be replaced with the Charpy impact test. The core of this study is to prove the correlation between the ballistic test and the impact test. As a result of ballistic test specimens manufactured with various welding parameters, the generated crack length showed a correlation of approximately 78% with impact toughness. In addition, cracks occurred at the weld toe and propagated along the fusion line irrespective of any variables. Therefore, the notch location of the impact test specimen was determined by the fusion line. Moreover, experiments proved that impact toughness did not change significantly when changing non-essential welding variables. The impact toughness of the fusion line critical values of MIL-A-12560 and MIL-A-46100 materials used in this study were 50 J and 22 J, respectively. This value exceeded the impact toughness management standard for the base material. Therefore, the passing threshold value was ultimately determined to be above the impact toughness threshold of the base material.

VRF 시스템의 고효율 부하대응 사이클 기술

사용철(Yong Cheol Sa),장지영(Ji Young Jang),송치우(Chi Woo Song),김형준(Hyung Joon Kim) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.4

VRF 시스템에어컨의 습도참조제어 기술에 대한 실증연구

박준성(Jun Seong Park),장지영(Ji Young Jang),윤필현(Pil Hyun Yoon),사용철(Yong Cheol Sa) 대한설비공학회 2018 대한설비공학회 학술발표대회논문집 Vol.2018 No.11

Paeparation and Properties of Epoxy Copolymers Containing Oxime-urethane Groups as Photobase Generators

채규호,송혜봉,선호용,장지영,Chae, Gyu Ho,Song, Hye Bong,Seon, Ho Yong,Jang, Ji Yeong Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.7

Epoxy copolymers containing oxime urethane groups were prepared by the polymerization of glycidyl methacrylate and N-[5-(benzophenoneoximinocarbonylamino)pentanyl]maleimide (BOPM). Their physical properties were characterized by GPC, DSC and TGA analyses. Photochemical changes of the copolymers were studied by UV, IR spectroscopy, and contact angle measurements. A photoinduced cross-linking reaction in copolymer films was observed by measuring the insoluble fraction. Irradiation of the copolymers at 254 nm UV light leads to the formation of pendant amino groups by photodissociation of the oxime-urethane groups. Treatment of the amino groups with HCl resulted in the formation of ammonium salts, which changed the polymer surface to be hydrophilic. An insoluble fraction of the copolymers increased with irradiation time, heating time, and heating temperature. Cross-linking of the epoxy resin effectively catalyzed by the photogenerated pendant amines upon heating.

대동맥주위 림프절에 재발된 자궁경부암에서 Taxol을 병행한 과분할 방사선치료의 결과

김준상(Jun Sang Kim),장지영(Ji Young Jang),김재성(Jae Sung Kim),김삼용(Sam Yong Kim),조문준(Moon June Cho) 대한방사선종양학회 2000 Radiation Oncology Journal Vol.18 No.1

목 적 : 대동맥주위림프절에 재발된 자궁경부암 환자의 치료방법으로 방사선민감제로 paclitaxel(Taxol)을 병행한 과분할 방사선치료에 대한 치료결과 및 부작용을 분석하여 치료의 유용성에 대해 알아보고자 하였다. 대상 및 방법 : 1997 년 9월부터 1999년 3월까지 충남대학교병원 치료방사선과에서 자궁경부암으로 골반부에 근치적 또 는 수술 후 방사선치료를 받은 후 대동맥주위림프절에 재발되어 Taxol을 병행한 과분할 방사선치료를 받았던 12명 환자중 30 Gy 이하의 방사선치료를 받은 2명을 제외한 10명을 대상으로 분석을 시행하였다. 대상환자의 연령은 31∼70세(중앙값 51세)이 었 고 초기 진단시 FIGO 병기는 IB1이 1명, IIA가 2명, IIB가 7명이었다. 대상환자 10 명중 7명이 재발 되기 전에 근치적 방사선치료를 받았고 3명이 수술 후 방사선치료를 받았으며, 근치적 방사선치료를 받았던 1명이 좌측 쇄골상관절종에 동시 재발한 상태였다. 방사선치료부위는 재발된 대동맥주위림프절을 포함하면서 위로는 12번 흉추부터 아래쪽으로는 과거에 치료받았던 골반조사부위 상연에서 조사야의 간 극 을 계산한 후 결정하였다. 일일 방사선 선량은 1.2 Gy, bid였고 총 방사선 선량은 50.4∼60 Gy (중 앙 선 량 58.8 Gy)로 조사하였다. 동시화학요법은 paclitaxel을 방사선민감제로 사용하였으며 방사선치료기간 중 매주 1회씩 체표면적당 20∼ 30 mg (중 앙 값 25 mg)을 정맥주사하였다. 방사선 치료기간동안 화학요법 총 횟수는 3∼6회(중앙값 4.5회) 시행하였다. 치료 후 추적기간은 3∼21개월(중앙값 9.5개월)이었다. 결 과 : 대동맥주위림프절에 재발까지의 무병생존기간은 2∼63 개월(중앙값 7개월)이었고, 대동맥주위림프절 치료 후 1년 생존율 및 중앙생존기간은 각각 75%와 9.5개 월 이 었 다. 그리고 1년 무병생존율 및 중앙무병생존기간은 각각 30%와 7개월이었다. 치료종료후 1개월에 시행한 복부전산화단층 촬영상 대상환자의 40% (4/10)가 완전관해를, 60% (6/10)가 부분관해를 보여 모든 치료환자에서 부분관해 이 상 의 치료반응을 보 였 다. 완전관해를 보였던 4명중 1명이 치료 후 8개월에 대동맥주위림프절에 재발하였고 부분관해를 보였던 환자중 2명에서 치료 후 각각 7개월과 12개월에 대동맥주위림프절 병소가 진행되었다. 치료 후 10명 중 6명에서 원격전이가 발생하였으며, 2명에서 골반부 림 프 절 에 재발하였다. 원격전이 부위로는 폐 3명, 뼈 3명, 쇄골상관절종에 3명이었다. 치료에 대한 혈액학적 급성합병증으로 1명 이 grade 4 백혈구 감소로 약 3주 간 방사선치료를 중단하였으며 grade 3 이상의 백혈구 감소가 2명이었고, grade 2 이상의 혈색소 감소 및 혈소판 감소가 각각 2명, 1명이었다. 상부위장관에 대한 급성합병증으로는 grade 2 이하의 오심 및 구토가 8명에서 발생하였으나 대부분 수용할만 하였다. 추적관찰 중 복부 또는 골반부위에 만성합병증은 관찰되지 않았다. 결 론 : 대동맥주위림프절에 재 발 된 자궁경부암 환자에서 방사선 민감제로 Taxol을 병행한 과분할 방사선치료를 하여 적은 합병증의 발생과 매우 높은 치료반응율을 보였다. 따라서 이러한 환자들에게 적극적인 치료로 사용될 수 있을 것으로 사료된다. Purpose : The aim of this study was to investigate treatment results, toxicity and efficacy of hyperfractionated radiation therapy combined with paclitaxel for paraaortic node recurrence in cervix cancer. Materials and Methods : Between September 1997 to March 1999, 12 patients with paraaortic node recurrence in cervix cancer who previously received radical or postoperative radiotherapy were treated with hyperfractionated radiation therapy combined with paclitaxel. Of these, 2 patients who irradiated l ess than 30 Gy were excluded, 10 patients were eligible for this study. Median age was 51 years. Initial FIGO stage was 1 stage IB1, 2 stage IIA, 7stage IIB. For initial treatment, 7 patients received radical radiotherapy and 3 received postoperative radi otherapy. The paraaortic field encompassed the gross recurrent disease with superior margin at T12, and inferior margin was between L5 and S1 with gap for previously pelvic radiation field. The radiation field was initially anterior and posterior opposed f ield followed by both lateral field. The daily dose was 1.2 Gy, twice daily fractions, and total radiotherapy dose was between 50.4 and 60 Gy(median, 58.8 Gy). Concurrent chemotherapy was done with paclitaxel as a radiosensitizer. Dose range was from 20 mg /m3 to 30 mg/m3 (median, 25 mg/m3), and cycle of chemotherapy was from 3 to 6 (median, 4.5 cycle). Follow-up period ranged from 3 to 21 months. Results : Interval between initial diagnosis and paraaortic node recurrence was range from 2 to 63 months (median, 8 months). The 1 year overall survival rate and median survival were 75% and 9.5 months, respectively. The 1 year disease free survival rate and median disease free survival were 30% and 7 months, respectively. At 1 month after treatment, 4 (40%) achiev ed a complete response and 6 (60%) experienced a partial response and all patients showed response above the partial response. There was distant metastasis in 6 patients and pelvic node recurrence in 2 patients after paraaortic node irradiation. There was 2 patients with grade 3 to 4 leukopenia and 8 patients with grade 1 to 2 nausea/ vomiting which was usually tolerable with antiemetic drug. There was no chronic complication in abdomen and pelvis during follow up period. Conclusion : Hyperfractionated radiation therapy combined with paclitaxel as a radiosensitizer showed high response rate and few complication rate in paraaortic node recurrence in cervix cancer. Therefore, present results suggest that hyperfractionated radiation therapy combined with paclit axel chemotherapy can be used as optimal treatment modality in this patients.

외상 환자 관리에서 Critical Pathway의 적용

심홍진 ( Hong Jin Shim ),장지영 ( Ji Yong Jang ),이재길 ( Jae Gil Lee ),김승환 ( Seong Hwan Kim ),김민정 ( Min Joung Kim ),박유석 ( You Seok Park ),박인철 ( In Chel Park ),김승호 ( Seung Ho Kim ) 대한외상학회 2012 大韓外傷學會誌 Vol.25 No.4

Purpose: For trauma patients, an early-transport and an organized process which are not delayed in hospital stage are necessary. Our hospital developed a procedure, the trauma Critical Pathway (CP), through which a traumatic patient has the priority over other patients, which makes the diagnostic and the therapeutic processes faster than they are for other patients. Methods: The records of patients to whom Trauma CP were applied from January 1, 2011 through April 15. 2012. were reviewed. We checked several time intervals from ER visiting to decision of admission-department, to performing first CT, to applying angio-embolization, to starting emergency operation and to discharging from ER. In addition, outcomes such as duration of ICU stay, hospital stay and mortality were checked and analyzed. Results: The trauma CP was applied to a total of 143 patients, of whom, 48 patients were excluded due to pre-hospital death, ER death, transferring to other hospital and not severe injury. Thus 95 patients(male 64, 67.3%) were enrolled in this study. Fifty-nine patients(62.1%) were injured by the traffic accident. The mortality rate was 10.5% and the mean Revised Trauma Score (RTS) of the patients was 6.4±2.0. After visiting ER, decision making for admission was completed, on average, in 3 hours 10 seconds. The mean time intervals for the first CT, angio-embolization, surgery and discharge were 1 hour 20 minutes, 5 hours 16 minutes, 7 hours 26 minutes and 6 hours 13 minutes, respectively. Conclusion: The trauma CP did not show the improvement of time interval outcome, as well as mortality rate. However, this test did show that the trauma CP might be able to reduce delays in procedures for managing trauma patients at the university-based hospitals. To find out the benefit of CP protocol, a large scaled data is required. (J Trauma Inj 2012;25:159-165)