Mice 소장의 Cajal 세포에서 기록되는 향도잡이 전류의 특성

장성종 ( Jang Seong Jong ),조은택 ( Jo Eun Taeg ),허광식 ( Heo Gwang Sig ),박찬국 ( Park Chan Gug ),김만우 ( Kim Man U ),장인엽 ( Jang In Yeob ),신무경 ( Sin Mu Gyeong ),차경훈 ( Cha Gyeong Hun ),염철호 ( Yeom Cheol Ho ),전제열 ( 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2

Background/Aims: Gastrointestinal motility is initiated by the periodic generation of slow waves. Interstitial cells of Cajal (ICC) are pacemaker cells that generate slow waves and drive spontaneous mechanical contractions of the gastrointestinal smooth muscle. Slow waves generate the periodic activation of spontaneous inward currents (pacemaker currents). The aim of this study was to investigate the characterization of pacemaker currents of ICC. Methods: The ICC in mice small intestine were cultured with stem cell factor for 2 days, and then we recorded pacemaker currents and slow waves using a whole-cell patch clamp technique. Results: Under voltage clamp at -80 mV of holding potential, ICC generated pacemaker currents. Tetrodotoxin and nifedipine did not affect on the pacemaker currents. In addition, tetraethylammonium, 4-aminopyridine and glibenclamide did not affect on the pacemaker currents. The reduction of external Na+ concentrations inhibited pacemaker currents. Moreover, these currents were completely abolished in the external Ca2+-free condition. Gadolinium and flufenamic acid, inhibitors of non-selective cationic currents, inhibited pacemaker currents. Thapsigargin and cyclopiazoic acid, inhibitors of Ca2+-ATPase in endoplasmic reticulum, abolished pacemaker currents. Carbachol depolarized membrane potential and increased inward currents. Conclusions: These results suggest that pacemaker currents are mediated by the activation of non-selective cation channel and become a target of neurotransmitters in regulation of intestinal motility. (Korean J Gastroenterol 2003;42:121-127)

무용동작치료 연구동향 분석 : 2010년~2020년 학위논문을 중심으로

장성화(Sung-Hwa JANG),이주연(Ju-Yeon LEE) 한국무용동작심리치료학회 2021 무용동작심리치료연구 Vol.5 No.1

연구는 2010년부터 2020년까지의 국내 석·박사 학위논문을 중심으로 무용동작치료의 연구동향을살펴보고자 하였다. 본 연구의 분석자료는 국회전자도서관과 한국교육학술정보원의 검색서비스를이용하여 석/박사 학위논문 총 120편을 대상으로 하였다. 선정된 자료는 연구문제에 맞게 코딩, 분석하였으며 연구 결과는 다음과 같다. 첫째, 2014년에 석박사학위논문 연구가 가장 많이 이루어졌음을 알 수 있으며, 2014년 이후 2020년까지 10편 이상의 꾸준한 학위논문 연구가 진행되고있음을 알 수 있었다. 둘째, 무용동작치료 학위논문의 연구대상은 성인이 가장 높은 비율을 보이고있었으며, 그 다음으로 유·아동, 청소년, 노인의 순으로 나타났다. 셋째, 연구방법은 양적연구의비율이 가장 높게 나타났고, 그 다음으로 통합적 연구, 질적연구, 문헌연구로 나타났다. 넷째, 프로그램 개발 및 효과연구가 가장 높은 비율을 차지하였고, 사례연구와 개관연구에 대한 연구가진행되고 있었다. 마지막으로 대상에 따라서 다양한 연구변인들을 중심으로 학위논문 연구가진행되었음을 알 수 있었다. The purpose of this study was to examine the research trends of dance movement therapy, focusing on domestic master s and doctorate thesis from 2010 to 2020. The analysis of this study was conducted on a total of 120 master s and doctorate papers using the search service of the National Assembly Electronic Library and the Korea Educational Information Service. The selected data were coded and analyzed according to the research problem, and the research results were as follows. First, it can be seen that the largest number of master s and doctorate thesis studies were conducted in 2014, and more than 10 steady thesis studies were conducted from 2014 to 2020. Second, adults showed the highest percentage of research subjects in the dissertation on dance movement therapy, followed by children, adolescents, and the elderly. Third, research methods showed the highest proportion of quantitative research, followed by integrated research, qualitative research, and integrative research. Fourth, program development and effectiveness research accounted for the highest percentage, and research on case studies and overview was being conducted. Finally, it was found that the dissertation research was conducted mainly by various research depending on the subject.

담낭 용종의 진단, 치료 및 추적 관찰의 최신 지견

장성일 ( Sung Ill Jang ),조재희 ( Jae Hee Cho ),이동기 ( Dong Ki Lee ) 대한소화기학회 2020 대한소화기학회지 Vol.76 No.3

A gallbladder (GB) polyp is an elevation of the GB mucosa that protrudes into the GB lumen. GB polyps have an estimated prevalence of 0.3-9.5% and can be divided into neoplastic (true) polyps and nonneoplastic polyps (pseudopolyps). Pseudopolyps are most commonly cholesterol polyps but also include focal adenomyomatosis and inflammatory polyps with no malignant potential. Neoplastic polyps, however, can be benign or malignant. Benign polyps are most commonly adenomas, while malignant polyps are usually adenocarcinoma. Transabdominal ultrasonography is the main radiological modality used for diagnosing and surveilling GB polyps. On the other hand, because it is difficult to diagnose GB polyps before surgery, alternative imaging modalities, such as endoscopic ultrasound, are being further evaluated. The current guidelines recommend cholecystectomy for GB polyps ≥ 10 mm in size as well as suboptimal sized GB polyps (6-9 mm) with other risk factors, including age >50, sessile, and symptoms. The quality of the evidence behind this practice is relatively low. Therefore, this review identifies the current gaps in the available evidence and guidelines and introduces methods that can help make decisions regarding patients who require a cholecystectomy or follow-up. (Korean J Gastroenterol 2020;76:102-107)

특별기고(特別寄稿) : 부모-자녀간의 의사소통, 또래관계가 청소년의 인터넷 문화에 미치는 영향

장성화 ( Sung Hwa Jang ),황윤미 ( Yoon Mee Hwang ),최성열 ( Sung Yeol Choi ),박영진 ( Young Jin Park ) 한국사상문화학회 2013 韓國思想과 文化 Vol.67 No.-

본 연구는 부모자녀간의 의사소통, 또래관계가 청소년의 인터넷 문화에 미치는 영향을 검증하고자 하였다. 이를 위해 대전광역시에 소재한 2개 중학생 238명과 2개 고등학교 216명을 대상으로 하였으며, 회수된 447부의 설문지 중 응답이 누락되었거나 불성실하게 작성한 47부를 제외한 총 400(중학생 208명, 고등학생 192)부를 가지고 SPSS WIN 18.0을 이용하였다. 분석결과는 다음과 같다. 첫째, 부모자녀간의 의사소통, 또래관계, 인터넷 문화간의 관계를 살펴보면, 부모자녀간의 의사소통과 인터넷 문화의 하위변인 중 아버지 개방형은 일상생활장애, 현실구분장애, 금단, 일탈행동, 내성, 어머니 개방형은 일상생활장애, 현실구분장애, 일탈행동, 내성, 어머니 문제형은 일상생활장애, 현실구분장애를 제외하고는 모든 하위변인들 간에 통계적으로 유의미한 부적상관이 있는 것으로 나타났다. 둘째, 중다회귀분석 결과에 따르면, 인터넷 중독을 가장 잘 설명해 주는 변인으로 교제의 지속성, 아버지 문제형, 친구와의 신뢰도로 나타났다. 이러한 결과를 바탕으로 청소년들의 인터넷 문화를 예측하는데 있어서 주요변수가 교제의 지속성에 있었기 때문에 또래관계 척도의 하위변수인 교제의 지속성와 인터넷 문화와의 관계에 대해 보다 심층적인 연구와 프로그램 개발의 필요성을 제시하고자 한다. The purpose of this study is to validate the effect of parent- child communication and peer relationship on adolescents Internet addiction. To achieve this goal, the survey was conducted targeting 234 students at two junior high schools and 216 students at two high schools located in Daejeon. 447 questionnaires were collected but 47 questionnaires containing missing and unfaithful answers were excluded. A total of 400 questionnaires(208 junior high school students, 192 high school students) was analyzed using SPSS WIN 18.0. Analysis results are as follows: First, upon examining the relationships among the parent-child communications, peer relationship and Internet addiction, father open mind type which is sub variable of parent-child communications and Internet addiction showed statistically significantly negative correlation between all sub variables except disturbance of daily living, disturbance of reality testing, withdrawal, deviate behavior and tolerance. Mother open mind type showed statistically significantly negative correlation between all sub variables except disturbance of daily living, disturbance of reality testing, deviate behavior and tolerance. Mother problem type showed statistically significantly negative correlation between all sub variables except disturbance of daily living and disturbance of reality testing. Second, according to the results from multiple regression analysis, it was shown that variables which explain Internet addiction very well were the duration of friendship, father problem type and reliability with friend. As a result, since the main variable to predict the adolescents Internet addiction is duration of friendship, we would like to present the necessity to conduct more in-depth study about relationship between duration of friendship which is the sub variable of scale for peer relationship and Internet addiction and to develop the program.

초등학생의 자아존중감, 학교적응, 정신건강이 휴대폰 중독에 미치는 영향

장성화 ( Sung Hwa Jang ),김순자 ( Soon Ja Kim ),최성열 ( Sung Yeol Choi ),이주연 ( Ju Yeon Lee ) 한국아동교육학회 2013 아동교육 Vol.22 No.4

본 연구에서는 초등학생의 자아존중감, 학교적응, 정신건강이 휴대폰 중독에 미치는 영향을 살펴보고, 초등학생의 휴대폰 중독 감소를 위한 개입의 기초자료로 활용하는데 정보를 제공하고자 하는 것을 목적으로 하였다. 이러한 목적을 달성하기 위하여 설정한 연구문제는 다음과 같다. 첫째, 초등학생의 자아존중감, 학교적응, 정신건강, 휴대폰 중독 간의 관계는 어떠한가? 둘째, 초등학생의 자아존중감, 학교적응, 정신건강이 휴대폰 중독에 미치는 영향은 어떠한가? 본 연구는 경기지역에 소재하고 있는 4개 초등학교에 재학중인 6학년 358명을 연구대상으로 선정하였다. 본 연구를 위해 수집된 자료는 SPSS 18.0 프로그램을 이용하여 분석하였다. 분석방법으로 첫째, 초등학생의 자아존중감, 학교적응, 정신건강, 휴대폰 중독간에는 어떠한 관계가 있는지 알아보기 위해 상관분석을 실시하였다. 둘째, 초등학생의 자아존중감, 학교적응, 정신건강이 휴대폰 중독에 미치는 영향이 어떠한가를 알아보기 위해 중다회귀분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 초등학생의 자아존중감, 학교적응, 정신건강, 휴대폰 중독 간의 상관관계를 살펴본 결과 자아존중감, 학교적응과 휴대폰 중독 간에는 부적상관, 정신건강과 휴대폰 중독간에는 정적 상관관계가 나타났다. 둘째, 초등학생의 휴대폰 중독에는 자아존중감, 학교환경적응, 정신건강의 측면들이 중요한 요인임을 밝혀졌다. The purpose of this study was to investigate the effects of self-esteem, school adjustment, mental health on elementary school students` cellular phone addiction. The findings of this study will provide the relevant educational authorities with basic data in order to prevent problems related to cellular phone addiction. The research questions were as follows. First, what kind of correlation are their among the degree of self-esteem, school adjustment, mental health on elementary school students` cellular phone addiction. Second, what are the effects of self-esteem, school adjustment, mental health on elementary school students` cellular phone addiction. The subjects of this study were 358 elementary school students located in Gyeonggi-do. The collected data were analyzed with correlations and multiple regressionusing SPSS 18.0. The results of this study were as follows. First, there were significant negative correlations between self-esteem and cellular phone addiction, there were significant negative correlations between school adjustment and cellular phone addiction, there were significant correlations between mental health and cellular phone addiction. Second, cellular phone addiction appeared to be influenced by the self-esteem, school adjustment, and mental health.

인삼의 항암작용에 대한 한의학 관련 논문 분석

장성일 ( Sung Il Jang ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2011 혜화의학회지 Vol.19 No.2

Backgrounds: Multidisciplinary approaches including surgery, chemotherapy, and radiation therapy are currently being performed to target various cancers in Western Medicine. However, some cancers still remain difficult to battle, which has long attracted many scientists for the discovery of new agents to fight cancers. Ginseng is one of the herbs used in Oriental Medicine including Korea, China and Japan. We have further investigated ginseng for its anticancer effect. Objective: This is a comprehensive review summary of anticancer effect of ginseng and ginsenoids as a possible agent for future cancer treatment. Methods: Data were retrieved from two web sites; www.pubmed.com and www.riss.kr, and authorized texts concerning anticancer effects of ginseng. From collected data, information on anticancer effect of ginseng was thoroughly sorted, restructured, then assessed. Results: Panax Ginseng C.A. Meyer belongs to Araliaceae Panax family, a perennial prairie plant with its root known as Ginseng Radix. Ginseng induces anticancer effect through cell cycle arrest, acceleration of apoptosis, anti-angiogenesis, and suppression of metastasis. Anticancer effect of ginseng may he due to single compound or multi-compound actions. Many studies report involvement of immune mechanisms of cytokines, Natural Killer (NK) cells, macrophages and some antibodies in enhancing anticancer effect of ginseng. In near future, possibility of applying these mechanisms into clinical trials is convinced. There were some important findings on saponin in ginsenoids in reviewing for this article; First, eradication of metastatic tumors were influenced by macrophage activation. Second, suppression of malignant melanoma cell metastasis to lung were induced by macrophage and NK cell activation in spleen with red ginseng acidic polysaccharide (RGAP). Third, final metabolites of M1, M4 had exerted anticancer effect of ginseng. Conclusion: Unknown anticancer mechanisms of ginseng have been studied for many years up until now. Ginseng is comprised of multiple bio-chemical compounds that create complex pharmaceutical interactions. Therefore, for its proper usage and safe prescription, studies on different types of ginseng and patients` susceptibility to ginseng according to their constitution and stages of the disease should be further pursued. More efforts are needed to understand the anticancer mechanisms of ginseng as well.

데이터 로깅(Data Logging)이란?

장성국(Sungkuk Jang) 한국자동차공학회 2010 오토저널 Vol.32 No.4

유비쿼터스 서비스 : SOA를 이용한 유비쿼터스 환경으로의 접근

장성진 ( Sung Jin Jang ) 대한산업공학회 2005 대한산업공학회 추계학술대회논문집 Vol.2005 No.-

명품과 배경음악이 충동적 의사결정에 미치는 영향

장성진 ( Seongjin Jang ),한광희 ( Kwanghee Han ) 한국감성과학회 2017 감성과학 Vol.20 No.1

본 연구에서는 상품과 배경음악이 사람들의 충동적인 의사결정에 미치는 영향을 지연 할인의 쌍곡선 함수를 이용하여 알아보았다. 구체적으로 상품과 배경음악에 따라 유의미한 이원 상호 작용이 존재했다. 명품 조건에서는 모차르트의 피아노 콘체르토 5번 장조 음악을 들었을 때, 20번 단조 음악을 들었을 때보다 충동성이 유의미하게 높았다. 하지만 실용 상품에 노출된 참가자들에게선 음악의 종류에 따라 충동성의 차이는 유의미하지 않았다. 추가 연구를 통해 음악을 더 세분화하여 빠르기를 조절하여 그 영향을 알아보았으며 동시에 정서가 위와 같은 결과를 매개 했는지 알아보았다. 결과적으로 정서의 매개효과와 빠르기의 주효과 모두 유의미하지 않았지만, 빠르기와 장단조 조건 간의 유의미한 이원 상호작용이 나타났다. 구체적으로 알레그로(allegro) 빠르기에서는 장조음악일 때가 단조 조건일 때보다 충동성이 높은 경향성이 나타났으며 안단테(andante) 빠르기에서는 장조 음악을 들었을 때가 단조 음악을 들었을 때보다 유의미하게 충동성이 낮게 나타났다. 우울한 정서를 예측 변수로 하고 미래 시간 길이 지각을 매개 변인으로 하여 추가연구를 진행한 결과, 시간 길이 지각은 우울한 정서가 충동성에 미치는 영향을 부분 매개함을 알 수 있었다. In this study, we figured out that music modes and item types could affect people`s urged decision making through a k-value which results from a delay discounting`s hyperbolic function. Generally, high k-value is related to impulsive decision making. Concretely, there was a significant interaction between items and music. For the luxury item, the k-value was higher while listening to major music than minor. However, for the non-luxury item condition the k-value difference was not significant between two pieces of music. Moreover, we expected mood could be manipulated after listening to the music and mediate a difference of tendency. We used first movement as an allegro and second as an andante of Mozart piano concerto No.5 D-major and No.20 D-minor for stimuli. As a result, mode and tempo`s main effects were not significant. Nevertheless, there was a significant two-way interaction. To put it concretely, the k-value of major condition was marginally higher than minor condition on allegro. However, the k-value of major condition was significantly lower than minor condition on andante. Also, depressed degree difference was significant but it was not significant as a mediator. Set depressed degree as a predict variable and future time span as a mediator, further research found future time perception partially mediated the effect that depressed degree affects impulsivity.

폐수 처리용 고전압 나노 펄스 발생기

장성덕(Sung-Duck Jang),손윤규(Yoon-Gyu Son),오종석(Jong-Seok Oh),권오정(O-Jung Kwon) 한국산업융합학회 2001 한국산업융합학회 논문집 Vol.4 No.3

The application of a pulsed power system is being extended to a environmental and industrial fields. The non-dissolution waste water pollutants from industrial plants can be processed by applying high voltage pulses with a fast rising time (a few nanoseconds) and short duration (nano to microseconds) in a pulsed corona discharge reactor. The nano-pulse generator with a magnetic switch has been developed. Its corona current in load can be adjusted by pulse width and repetition rate. we investigated the performance of the nano-pulse generator using the dummy load which is composed of resistor and capacitor equivalent to the actual reactor. This paper descibes the electrical characteristics of the nano-pulse generator that produces a 300 ns pulse at maximum repetition rate of 400 pps with a voltage of 40 kV across a 640 Ω load. In this paper we briefly discuss a configuration of system and test results.<br/>