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Smoking and Type 2 Diabetes Mellitus
장상아 대한당뇨병학회 2012 Diabetes and Metabolism Journal Vol.36 No.6
Cigarette smoking is a well-known risk factor in many diseases, including various kinds of cancer and cardiovascular disease. Many studies have also reported the unfavorable effects of smoking for diabetes mellitus. Smoking increases the risk of developing diabetes, and aggravates the micro- and macro-vascular complications of diabetes mellitus. Smoking is associated with insulin resistance,inflammation and dyslipidemia, but the exact mechanisms through which smoking influences diabetes mellitus are not clear. However, smoking cessation is one of the important targets for diabetes control and the prevention diabetic complications.
원위부 신세뇨관성 산증으로 발현한 Sjo¨gren Syndrome 1예
장상아,한제호,손현식,윤건호,조철수,차봉연,김호연,이광우,손호영,강성구 대한내과학회 1993 대한내과학회지 Vol.44 No.6
저자들은 저칼륨혈증을 주증상으로 내원한 환자에서, 원위부 신세뇨관성 산증으로 발현된 Sjo¨gren's 증후군 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Distal renal tubular acidosis is a condition characterized by an inability of the distal nephron to acidify the urine, causing hyperchloremic metabolic acidosis, hypercalciuria, hypokalemia, nephrocalcinosis, and nephrolithiasis. Both hereditary and aquired forms have been described, the latter commonly associated with immune-mediated disorders. It has recently been noted that diseases characterized by hyperglobulinemia are occasionally complicated by renal tubular acidosis, and this combination of hyperglobulinemia and renal tubular acidosis has been reported in Sjo¨gren's syndrome and other immune-mediated disorders. Recently we experienced a case of Sjo¨gren's syndrome of which manifestations were severe hypokalemia, and other features of distal renal tubular acidosis. We presents a case of Sjo¨gren's syndrome complicated by renal tubular acidosis with literature review.
제2형 남자 당뇨병환자에서 비만과 비비만에 따른 아디포넥틴의 혈중 농도와 다중결합체의 차이
장상아 ( Sang Ah Chang ),손호영 ( Ho Young Son ),이정민 ( Jung Min Lee ),손태서 ( Tae Seo Sohn ),권혁상 ( Hyuk Sang Kwon ),손현식 ( Hyun Shik Son ),윤건호 ( Kun Ho Yoon ),김희승 ( Hee Seung Kim ),차봉연 ( Bong Yun Cha ),이광우 ( K 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.3
유순집,장상아,손태서,권혁상,이정민,문성대,Pieter Proot,Paldánius Päivi Maria,윤건호 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.6
We assessed the glycaemic durability with early combination (EC; vildagliptin+metformin [MET], n=22) versus MET monotherapy (n=17), among newly-diagnosed type 2 diabetes mellitus (T2DM) enrolled (between 2012 and 2014) in the VERIFY study from Korea (n=39). Primary endpoint was time to initial treatment failure (TF) (glycosylated hemoglobin [HbA1c] ≥7.0% at two consecutive scheduled visits after randomization [end of period 1]). Time to second TF was assessed when both groups were receiving and failing on the combination (end of period 2). With EC the risk of initial TF significantly reduced by 78% compared to MET (n=3 [15%] vs. n=10 [58.7%], P=0.0228). No secondary TF occurred in EC group versus five patients (29.4%) in MET. Patients receiving EC treatment achieved consistently lower HbA1c levels. Both treatment approaches were well tolerated with no hypoglycaemic events. In Korean patients with newly diagnosed T2DM, EC treatment significantly and consistently improved the long-term glycaemic durability as compared with MET.