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전염증성 사이토카인에 의해 유도된 베타세포 자연사에 대한 유비퀴틴화를 통한 GLP-1의 보호효과
임동미,김주영,이강우,박근용,김병준 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.2
Background: Proinflammatory cytokines are one of the causes of diabetes mellitus. However, the exact molecular mechanism by which proinflammatory cytokines induce β-cell death remains to be clearly elucidated. Glucagon-like peptide-1 (GLP-1) affects the stimulation of insulin secretion and the preservation of β-cells. Additionally, it may exert an antiapoptotic effect on β cells; however,the mechanism underlying this effect has yet to be demonstrated. Therefore, we investigated the protective effects of GLP-1 in endoplasmic reticulum (ER)-mediated β-cell apoptosis using proinflammatory cytokines. Methods: To induce ER stress, hamster insulin-secreting tumor (HIT)-T15 cells were treated using a mixture of cytokines. Apoptosis was evaluated via MTT assay, Hoechst 33342 staining, and annexin/propidium iodide (PI) flow cytometry. The mRNA and protein expression levels of ER stress-related molecules were determined via PCR and Western blotting, respectively. Nitric oxide was measured with Griess reagent. The levels of inducible nitric oxide synthase (iNOS) mRNA and protein were analyzed via real-time PCR and Western blot, respectively. iNOS protein degradation was evaluated via immunoprecipitation. We pretreated HIT-T15 cells with exendin (Ex)-4 for 1 hour prior to the induction of stress. Results: We determined that Ex-4 exerted a protective effect through nitric oxide and the modulation of ER stress-related molecules (glucose-regulated protein [GRP]78, GRP94, and CCAAT/enhancer-binding protein homologous protein [CHOP]) and that Ex-4stimulates iNOS protein degradation via the ubiquitination pathway. Additionally, Ex-4 also induced the recovery of insulin2 mRNA expression in β cells. Conclusion: The results of this study indicate that GLP-1 may protect β cells against apoptosis through the ubiquitination pathway.
제2형 당뇨병환자에서 각 대사증후군의 정의(WHO, NCEP-ATP III, IDF)에 따른 심혈관질환의 예측능 비교
임동미,고관표,박근용 대한당뇨병학회 2008 Diabetes and Metabolism Journal Vol.32 No.2
Background: Metabolic syndrome (MetS) is constellation of cardiovascular risk factors. There are three typically used definitions of MetS proposed by WHO, IDF and NCEP-ATP III. We conducted this study to compare the associations of MetS by WHO, IDF and NCEP-ATP III definition to various metabolic markers of coronary heart diseases in Korean type 2 diabetes patients.Methods: We enrolled 151 Korean type 2 diabetes patients in one hospital. Anthropometric and biochemical parameters, including high-sensitivity C-reactive protein (hsCRP), homocysteine, uric acid were measured. And then, we divided MetS group from non-MetS group according to three other definitions.Results: Serum hsCRP level was higher in those with MetS group than non-MetS group by WHO definition (0.33 ± 0.36 mg/dL vs 0.18 ± 0.26 mg/dL, P < 0.001). But, there are no difference in MetS group and non-MetS group by IDF and NCEP-ATPIII definition. (By IDF, 0.28 ± 0.31 mg/dL vs 0.25 ± 0.34 mg/dL, P = 0.64; By NCEP-ATP III, 0.28 ± 0.33 mg/dL vs 0.22 ± 0.32 mg/dL, P = 0.41). Uric acid and homocysteine levels were higher in those with MetS by WHO definition (P < 0.05). Similarly, analyses according to IDF and NCEP ATP III definition showed no significant difference.Conclusion: In conclusion, WHO definition of MetS has a stronger relationship with the biochemical markers of coronary heart disease in Korean type 2 diabetes patients. (KOREAN DIABETES J 32:157~164, 2008)
양측성 알도스테론 생성 선종으로 오인될 수 있었던 특발성 고알도스테론증 1예
임동미 ( Dong Mee Lim ),박근용 ( Keun Yong Park ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1
저자들은 난치성 고혈압과 저칼륨혈증을 보인 환자에서 원발성 알도스테론증의 원인을 조사하던 중 부신 전산화 단층 촬영에서 양측성 알도스테론 생성 선종의 소견이었으나, 알도스테론의 체위변화 검사와 부신정맥 도자술을 통하여 양측성의 특발성 알도스테론증으로 진단한 증례를 경험하였기에 보고하는 바이다. In most cases, primary aldosteronism is due to a unilateral adrenal adenoma or bilateral hyperplasia of the adrenal cortex. However, a few bilateral adrenal tumors have also been reported in primary aldosteronism. In such cases, it is important to differentiate bilateral aldosterone-producing adenomas from bilateral adrenal hyperplasia so as to develop the optimal treatment plan. We report a case of idiopathic hyperaldosteronism due to bilateral adrenal hyperplasia that could have been misdiagnosed as a bilateral aldosterone-producing adenoma. An adrenal CT scan revealed bilateral adrenal tumors (1.5 cm [right] and 3.6 cm [left] in diameter). Idiopathic hyperaldosteronism was properly diagnosed using a posture test and selective adrenal venous sampling.(Korean J Med 75:93-97, 2008)