치면세마방법에 따른 치면열구전색재의 변연 누출도에 관한 실험적 연구

이흥교,이상호 朝鮮大學校 口腔生物學硏究所 1994 口腔生物學硏究 Vol.18 No.2

치면세마방법에 따른 치면열구전색재의 변연누출도에 관한 실험적 연구

이상호,이흥교 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

The purpose of this study was to evaluate the degree of microleakage of the sealants according to the methods of prophylaxis. 90 sound human teeth and 2 types of sealants, light cured type(Teethmate-F,Japan) and dual cured type(Bisco, USA) were used. Samples were divided in to 4 groups according to the methods of prophylaxis. The groups were as follows : Group Ⅰ: rubber cup+pumice Group Ⅱ: Brush+pumice Group Ⅲ: Prophylactic odontomy Group Ⅳ: Air - polishing 10 teeth were used for cleaning state of pit and fissure by methods of prophylaxis and observed by SEM. 80teeth were used for the degrees of dye penetration in the fissure walls were assessed by steroscope at x10 magnification. The data was analyzed statistically by Chi-square test. The results were as follows : 1. Air-polshing method was the most effect on removal of organic materials in pit and fissure, and the prophylactic odontomy was more effective than those of rubber cup and pumice, brush and pumice method. 2. No significant difference in microleakage was showed between light cured sealant and dual cured sealant(P>0.05). 3. Air-polishing method showed the least degree of microleakage of the sealants of all prophylaxis methods. Prophylactic odontomy method showed less degree of microleakage than those of bursh and pumice, rubber cup and pumice method.

치면세마방법에 따른 치면열구전색재의 변연 누출도에 관한 실험적 연구

이흥교(Heung Gyo Lee),이상호(Sang Ho Lee) 조선대학교 구강생물학연구소 1994 Oral Biology Research (Oral Biol Res) Vol.18 No.2

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Multiloop Edgewise Arch Wire를 이용한 정중변위 밍 전치부 개방교합을 동반한 제3급 부정교합의 치료증례

이흥교,이상호,유종만 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.2

The purpose of early orthodontic treatment is to guide the dentitions toward the development of a functionally and morphologically harmonious occlusion. Early treatment of CI.Ⅲ malocclusion is useful to establish the normal occlussion and induce to proper seating for the condyle in the fossa. CI.Ⅲ malocclusion is treated with 3 categories of methods, such as orthodontic tooth movement, modification of growth and orthognathic surgery. This report presents a case of classⅢ malocclusion accompanying the midline shift and anterior openbite treated with Multiloop Edgewise Arch Wire(MEAW) mechanics. Treatment resulted in normal classⅠ molar relationship and functional overbite& overjet. Extrusion of anterior teeth and distal uprighting of posterior teeth were also observed. Further observation is needed to evaluation the stability or recurrence of these cases treated with MEAW.

성염색체이상증후군의 핵형 분석

서현지,이지혜,이흥교,이건수,정승희 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.12

Purpose : This study was performed to evaluate the recent frequency of karyotypes in different sex chromosome abnormalities and to evaluate the age and clinical manifestations at diagnosis. Methods : Peripheral blood leukocytes were obtained from subjects who were clinically suspected to have sex chromosome abnormalities and referred to the cytogenetic laboratory in the Department of Pediatrics, Kyungpook National University Hospital from February 1981 to August 2001. Results : The relative frequencies of different sex chromosome abnormalities were Klinefelter(52 percent), Turner(42 percent), XXX syndrome(3 percent) and mixed gonadal dysgenesis(3 percent). The populations of different karyotypes in Klinefelter syndrome were 47,XXY(97 percent) and 46,XY/ 47,XYY(3 percent). The populations of different karyotypes in Turner syndrome were 45,X(67 percent,), mosaicism(23 percent), and structural aberrations(10 percent). The populations of different karyotypes in XXX syndrome were 47,XXX(67 percent,) and 46,XX/47,XXX(33 percent). All mixed gonadal dysgenesis were 45,X/46,XY. Eighty one percent of sex chromosome abnormalities was diagnosed after puberty. Patients diagnosed with Klinefelter and Turner syndrome in infancy showed nearly normal phenotypes or had minor congenital malformations. Conclusion : Early diagnoses of sex chromosome abnormalities is required to prevent associated morbidities and to maximize growth and development. We have to pay careful attention in diagnoses of Turner syndrome because of the high proportion of mosaicism and structural aberrations. 목 적 : 성염색체이상증후군은 사춘기 이후 이차 성징의 결여로 그 증상이 뚜렷해지므로 사춘기 이전의 진단은 쉽지 않다. 본 연구는 성염색체이상증후군의 빈도, 진단시 연령, 그리고 임상적 특징을 조사하여 그 의의를 알아보고자 한다. 방 법 : 1981년 2월부터 2001년 8월까지 20년 동안 경북대학교병원 소아과 염색체검사실에 의뢰된 염색체검사 중 성염색체이상증후군으로 진단된 115례 환자의 임상적 특징, 진단시 연령 그리고 핵형 분석을 후향적인 방법으로 조사하였다. 결 과 : 성염색체이상증후군의 종류와 빈도는 Klinefelter 증후군은 52%, Turner 증후군은 42%, XXX 증후군은 3%, 혼합 성선이형성은 3%였다. Klinefelter 증후군은 47,XXY가 97%, mosaicism이 3%였고, Turner 증후군은 45,X가 67%, mosaicism이 23%, X 염색체의 구조적 이상은 10%였다. XXX 증후군은 47,XXX가 67%, mosaicism은 33%였고, 혼합 성선이형성은 모두 45,X/46,XY였다. 성염색체이상증후군의 81%가 사춘기 이후에 진단되었다. 신생아기에 Klinefelter 증후군과 Turner 증후군으로 진단받은 경우는 표현형이 정상이거나 경한 선천성기형만을 보였다. Turner 증후군과 Klinefelter 증후군의 mosaicism이나 구조적 이상군에서 전형적인 45,X나 47,XXY보다 신체상 증상 발현이 경미할 것으로 생각되었으나 본 연구에서는 통계학적으로 유의한 차이는 보이지 않았다.

말초혈액을 이용한 핵형 분석 4,500례 : 단일기관에서의 25년간의 경험

서혜은,이지혜,김지윤,이동하,이흥교,이건수 대한소아청소년과학회 2007 Clinical and Experimental Pediatrics (CEP) Vol.50 No.9

Purpose : Chromosome analysis is important in genetic study and genetic counseling. This study was performed to evaluate the type and incidence of chromosome abnormalities in a single hospital for 25 years. Methods : Chromosome analyses were performed on peripheral blood lymphocytes, obtained from 4,856 patients with suspected chromosomal aberrations, referred to cytogenetic laboratory in Department of Pediatrics, Kyungpook National University Hospital from May 1981 to October 2005. Results : We analyzed 4,567 cases. Children were 3,014 cases (66.0%) and adult were 1,553 cases (34.0 %). The most common purpose of the chromosomal analysis was growth and developmental abnormality in children and infertility in adults. Total chromosomal aberration rate was 16.9% (770/4,567). Among those cases, the numerical abnormalities were 12.2% (558 cases), the structural abnormalities were 4.1% (187 cases), and others were 0.5% (25 cases). The relative frequencies of autosomal abnormalities were 6.4% (294 cases) in Down syndrome; 0.2% (7 cases) in Edwards syndrome; 0.1% (4 cases) in Patau syndrome; 0.2% (10 cases) in other abnormalities, of sex chromosome, 2.9% (131 cases) in Klinefelter syndrome; 2.2% (99 cases) in Turner syndrome; 0.2% (8 cases) in 47, XXX; 0.1% (3 cases) in 47, XYY. Among the structural abnormalities, translocation was 1.8% (84 cases), inversion was 0.8% (37 cases), deletion was 0.4% (17 cases), and insertion was 0.3% (13 cases), in order of frequency. Conclusion : In this study, the type, incidence and distribution of cytogenetic abnormalities by karyotype were reviewed. We hope that our study could be used as a basic information on the diagnosis, treatment and genetic counseling for chromosome abnormalities in Korea. 목 적 : 염색체의 구조 및 유전을 연구하는 학문인 세포유전학은 임상 진단, 생식 문제, 산전 진단, 종양, 유전자의 다형성 및 유전 상담에 있어 중요한 역할을 하고 있다. 이 연구는 단일 기관에서 시행된 말초혈액을 이용한 세포유전학 검사 결과를 검토하여 주요 염색체 이상의 양상과 빈도를 분석하였다. 방 법 : 1981년 5월부터 2005년 10월까지 25년간 경북대학교병원 소아과 염색체 검사실로 각 임상 진료과에서 염색체 이상이 의심되어 의뢰한 말초혈액 검체 4,856례를 대상으로 하여 염색체 핵형을 분석하였다. 결 과 : 총 4,856례 가운데 4,567례를 분석하였다. 이 중 소아는 3,014례(66.0%), 성인은 1,553례(34.0%)였으며, 검사를 의뢰한 가장 흔한 이유는 소아에서는 성장과 발달 장애, 성인에서는 생식 문제였다. 4,567례 중 염색체 이상은 770례(16.9%)에서 발견되었다. 염색체 이상 중 수적 이상은 558례(12.2%), 구조적 이상은 187례(4.1%)였으며, 취약부위나 염색체 파손과 같은 이상이 25례(0.5%)였다. 수적 이상 중 상염색체 이상은 Down 증후군이 294례(6.4%)로 가장 많았으며, Edwards 증후군 7례(0.2 %), Patau 증후군 4례(0.1%) 순이었다. 성염색체의 이상은 Klinefelter 증후군이 131례(2.9%)로 가장 많았고, Turner 증후군 99례(2.2%), XXX 증후군 8례(0.2%), XYY 증후군 3례(0.1%) 순이었다. 구조적 이상은 전위가 84례(1.8%)로 가장 많았다. 결 론 : 본 연구에서 염색체 이상 핵형의 유형과 그 양상을 파악하였으며, 적극적 세포유전학적 연구로 진료와 유전상담에 적용하여야 할 것이다.