소음인(少陰人) 태음병(太陰病) 심하비증(心下?證)의 병증약리(病證藥理) 고찰

서영광,이지원,이준희,최원철,이의주,고병희,Seo, Young-Kwang,Lee, Ji-Won,Lee, Jun-Hee,Choi, Won-Cheol,Lee, Eui-Ju,Kho, Byung-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3

1. Objective: Gastric Stuffiness (心下?證) in the Soeumin Taeeum symptomatology (少陰人 太陰病) in Sasang Constitutional Medicine shows an interesting evolutionary process. Originally found in the texts of Sanghanlun (傷寒論), the perspectives regarding the symptoms of Gastric Stuffiness were expanded by many medical scholars and Lee Jema. To comprehend the Jema's concept of Taeeum symptomatology and utilize his prescription clinically, it deserves to study on the Gastric Stuffiness in Donguisuseowon (東醫壽世保元). 2. Methods: Many texts including Sanghanlun (傷寒論) and Dongeuibogam (東醫寶鑑) were reviewed in order to track the evolutionary process concerning the symptoms of Gastric Stuffiness. Also, Lee Jema's works including the different versions of Donguisuseowon (東醫壽世保元) were reviewed to examine the development of Lee's concepts regarding the Gastric Stuffiness in the Soeumin Taeeum symptomatology. 3. Results and Conclusions: 1) Most of the previous concepts on Gastric Stuffiness were generally similar to those found in Sanghanlun, especially in that they addressed Yang deficiency of the middle triple energizeer as the central pathogenic process. 2) Lee Jema's views on the epigastric discomfort in the Soeumin Taeeum symptomatology evoloved over time and culminated in the finalized pathology and therapeutics appearing in his last work, the Shinchuk version of Donguisuseowon (東醫壽世保元). 3) 4 kinds of prescription which invented by Lee Jema to treat the Gastric Stuffiness in the Soeumin Taeeum symptomatology can be matched to the prescription of Sanghanlun respectively. However through evolutionary process of Jema's prescriptions, the indication of them expanded: not only to treat Gastric Stuffiness but to diverse symptoms of Soeumin.

소양인(少陽人) 망음증(亡陰證)의 치방(治方)에 대한 고찰(考察)

이지원,이준희,고병희,이의주,Lee, Ji-Won,Lee, Jun-Hee,Koh, Byung-Hee,Lee, Eui-Ju 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Background: This is the first documented study on the four medications for the Mangeum symptomatology (亡陰證) in the Soyangin disease category. The four medications, Hyeongbangsabaek-san (荊防瀉白散), Jeoryeongchajeonja-tang (猪?車前子湯), Hyeongbangjihwang-tang (荊防地黃湯), and Hwalseokgosam-tang (滑石苦蔘湯), were comparatively analyzed on their compositive principles and respective symptomatologies. 2. Methods: Previous literature, including classical works on earlier Sasang Constitutional Medicine (different editions of Donguisusebowon and Dongmuyugo), were reviewed for relevant material on the Mangeum medications. 3. Results and Conclusions: 1) Hyeongbangsabaek-san (荊防瀉白散) is used in pathologies of early stages of invasion of the internal heat in the lower-most burn-center (locus related to the Kidney system). 2) Jeoryeongchajeonja-tang (猪?車前子湯) is used when pathogenic dampness-heat invades the lower-most burn-center (locus related to the Kidney system). 3) Hyeongbangjihwang-tang (荊防地黃湯) is used to treat deficient heat involving injury of the lower-most burn-center (locus related to the Kidney system). 4) Hwalseokgosam-tang (滑石苦蔘湯) is used when the lower-most burn-center (locus related to the Kidney system) is in the early stages of exhaustion, expecially accompanied by concomitant dampness-heat. 5) The Mangeum symptomatology (亡陰證) was fully understood only after the completion of the 1901 Sinchuk edition (辛丑本) of Donguisusebowon (東醫壽世保元).

열다한소탕으로 호전된 태음인 호산구성대장염 환자 1례

이지원,김진영,오혜원,이의주,고병희,이준희,Lee, Ji-Won,Kim, Jin-Young,Oh, Hye-Won,Lee, Eui-Ju,Koh, Byung-Hee,Lee, Jun-Hee 사상체질의학회 2015 사상체질의학회지 Vol.27 No.4

Objectives The aim of this study was to report an improvement on the symptoms of Eosinophilic Colitis (EC) by Yeoldahanso-tang.Methods The patient was diagnosed with Taeumin Ganyeol-paeJo Symptomatology and treated with Yeoldahanso-tang. The gastroendoscopy and eosinophilic infitration of mucosa of colitis are investigated. Also patient's subjective symptom of abdominal pain was scored using the Numerical Rating Scale(NRS) during the treatment period. And the number of defecation in a day is also used to decide the degree of colitis.Results and Conclusions The patient had been treated from December 13, 2014 to August 8, 2015. Eosinophilic infiltration of colon was disappeared after the treatment although chronic inflammation still existed. Subjective pain of abdominal pain was measured as NRS 6~8 at the beginning of the remedy, but diminished through the treatment sessions and became NRS 0 in the end. The number of defecation was in average 3, and at the endpoint it became 1. In conclusion, this study suggests that Sasang constitutional Medicine used for treating EC of Taeumin may be effective.

열다한소탕(熱多寒少湯)으로 양수(兩手) 진전(振顫), 안면(顔面) 상열감(上熱感), 어미삽(語微澁)을 치료한 태음인(太陰人) 환자 1예(例)

이지원,장현수,김윤희,이준희,이의주,고병희,Lee, Ji-Won,Jang, Hyun-Su,Kim, Yun-Hee,Lee, Jun-Hee,Lee, Eui-Ju,Koh, Byeong-Hee 사상체질의학회 2009 사상체질의학회지 Vol.21 No.1

1. Objective This case study reports a Taeeumin patient experiencing hand tremor, heat flash, and mild dysarthria who improved with Yeoldahansotang medication. 2. Method The patient's subjective and objective symptoms were observed daily, and the VAS scores for the main symptoms (hand tremor, heat flash, and mild dysarthria) were recorded daily throughout hospitalization period. 3. Result The patient's general conditions improved by the end of hospitalization, and VAS score dropped dramatically from VAS 10, VAS 10, VAS 10 to VAS 0, VAS 0.5, VAS 3 for hand tremor, heat flash, and mild dysarthria, respectively. 4. Conclusion The patient responded well to Yeoldahansotang, one of the main medicaments for the Joyeol (dry-heat) symptomatic pattern, which indicates that Yeoldahansotang can be used to treat the Joyeol symptomatic pattern even when the textbook indications are not evident as long as the Joyeol pathology is recognizable from other symptoms.

사상체질의학적 병리관에 의한 "상한론(傷寒論)" 태양병(太陽病)의 재해석

이지원,신승원,곽상협,김영준,이준희,Lee, Ji-Won,Shin, Seung-Won,Kwak, Sang-Hyup,Kim, Yeong-Jun,Lee, Jun-Hee 사상체질의학회 2010 사상체질의학회지 Vol.22 No.3

1. Objectives: Purpose of this paper is to study the reinterpretation of Taeyang disease(太陽病) in "Shanghanlun(傷寒論)" based on the pathologic perspective of Sa-sang Constitutional Medicine by comparing factors as pathologic mechanisms, clinical symptoms, and remedies. 2. Methods: The texts referred to pathologic mechanisms, clinical symptoms, and remedies of Taeyang disease(太陽病) described in "Donguisusebowon Gabobon(東醫壽世保元 甲午本)", "Donguisusebowon Sinchookbon(東醫壽世保元 辛丑本)", and Shanghanlun(傷寒論)" in "Donguibogam(東醫寶鑑)" were analysed. 3. Results and Conclusions 1) Early phase of Ulgwang symptomatic pattern(鬱狂證 初證) and of Mangyang symptomatic pattern(亡陽證初證) of Kidney Heat-based Exterior Heat disease(腎受熱表熱病), a category of Soeumin(少陰人) diseases, were described by adopting pathologic models of Taeyang-sangpung symptomatic pattern(太陽傷風證) and Sanghan-hyeol symptomatic pattern(傷寒血證) from "Sanghanlun(傷寒論)". 2) Soyang-sangpung symptomatic pattern(少陽傷風證) of Spleen Cold-based Exterior Cold diseae (脾受寒表寒病) and Hyunggyeok-yeol symptomatic pattern(胸膈熱證) of Stomach Heat-based Interior Heat disease(胃受熱裏熱病), categories of Soyangin(少陽人) diseases, were described by adopting pathologic models of Taeyang-yangsangpunghan symptomatic pattern(太陽兩傷風寒證), Soyang-sangpung symptomatic pattern(少陽傷風證) and Tayangbyong-sahak symptomatic pattern(太陽病似?證) from "Sanghanlun(傷寒論)". 3) Baechu-pyo symptomatic pattern(背?表病輕證) and Hangual symptomatic pattern(寒厥證) of Esophagus Cold-based Exterior Cold disease(胃脘受寒表寒病), a category of Taeeumin(太陰人) diseases, was described by adopting pathologic models of Taeyang-sanghan symptomatic pattern(太陽傷寒證) and Hangual symptomatic pattern(寒厥證) from "Sanghanlun(傷寒論)". 4) Je-Ma Lee reinterpreted various diseases classified as Taeyang disease(太陽病) with the pathologic perspective of Sa-sang Constitutional Medicine. Different from existing medicine, diseases were analysed and treated by the standard, constitution of the patient.

미역취뿌리 추출물이 성장기 흰쥐의 골대사에 미치는 영향

이지원,박정현,이효주,이인선,Lee Ji-Won,Park Jung-Hyun,Lee Hyo-Joo,Lee In-Seon 한국생명과학회 2005 생명과학회지 Vol.15 No.2

본 연구에서는 3주령의 암컷 흰쥐를 이용하여 미역취뿌리 추출물이 골대사에 미치는 영향을 조사하고자 미역취뿌리 메탄올 추출물을 10, 50, 100 mg/kg/day의 농도로 음용수에 희석하여 9주간 사육시켰다. 매주 체중과 사료효율을 측정한 결과, 대조군에 비해 체중의 변화나 사료효율에는 유의적으로 차이가 없는 것으로 보아 미역취 뿌리 추출물에 대한 기본적 독성은 없고, 성장에 미치는 영향은 없는 것으로 사료되었다. 그리고 3주 간격으로 소변으로 배출되는 Ca과 P의함량을 ICP로 분석 한 결과, 10 mg/kg/day농도로 음용한 군에서 유의적으로 감소됨을 확인 할 수 있었고 혈액으로 유리되는 Ca과 P의 함량 또한 섭취군에서 유의적으로 감소되는 것을 확인하였다. 또한 섭취 후 9주째에 양에너지 방사선 골밀도 측정기(dual energy x-ray absorptiometry, DEXA)를 이용하여 척추, 대퇴골, 골반의 골밀도와 골무기질 함량을 측정한 결과, 메탄을 추출물을 음용한 군의 척추 골밀도가 대조군에 비해 유의적으로 높게 나타났으며, 글 무기질 함량 또한 대퇴골과 골반에서 대조군에 비해 유의적으로 높게 나타났다. 따라서 미역취뿌리 메탄을 추출물의 음용이 암컷 흰쥐에서 골밀도 및 골함량에 유의하게 작용하고 또한 골대사 과정에서 유리되는 Ca와 P의 대사과정에 작용하여 유리되는 Ca과 P의 양을 감소시켜 이상의 결과로 미뤄볼 때, 적절한 미역취뿌리 추출물의 투여는 흰쥐의 성장에 대해 부작용이나 독성없이 골밀도와 골무기질 함량을 높였으며 앞으로 조골세포 기능 저하로 인한 골대사 질환에 사용되어 질 수 있을 것이다. To investigate the bioactivities of Solidago virga-aurea var. gigantea Mig. Root (SVR), we studied the effect of a SVR methanol extract on the activity of bone metabolism. Spraque-Dawley three-week-old female rats were randomly assigned to groups as follows : non-supplemented rats and supplemented with SVR at 10, 50, 100 mg/kg bw/day. Every week determined weight gain and food intake, urine and blood examination of mineral content of calcium and phosphorus was performed each at experimental periods of 3 and 9 weeks respectively; bone mineral density and bone mineral content were also assayed. There were no significant differences in body weight or feed efficiency ratio levels. However, the biological value of calcium and phosphorus excretion in the group supplemented with SVR extract decreased significantly more than that in the group not supplemented with SVR extract. Also, spine BMD, femur BMC and pelvis BMC per weight were significantly greater on SVR extract supplemented groups than that of the control group. In conclusion, it might be expected that methanol extract of SVR does not impair the growth of rats and may improve bone metabolism in rats.

Effect of Omega-3 and Korean Red Ginseng on Children with Attention Deficit Hyperactivity Disorder: An Open-Label Pilot Study

이지원,Areum Lee,김지훈,Yun Mi Shin,김성주,Woo Dong Cho,Soyoung Irene Lee 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: The purpose of the present study was to evaluate the efficacy of omega-3 and Korean red ginseng on improving attention deficit hyperactivity disorder (ADHD) symptoms and cognitive function in children with ADHD. Methods: A total of 40 children aged 6 to 12 years diagnosed with ADHD participated in this open-label trial. Participants received daily supplements containing 500 mg of omega-3 (eicosapentaenoic acid, 294 mg; docosahexaenoic acid, 206 mg) and 3 mg of Korean red ginseng extract (combination of ginsenoside Rg1, Rb1, and Rg3) for 12 weeks. No psychotropic drug was allowed during the study period. ADHD symptoms were assessed using the ADHD Rating Scale (ADHD-RS) and Clinical Global Impression-Severity (CGI-S) scale. Neuropsychological tests on sustained attention, short-term memory, and executive function were also assessed. Results: After 12 weeks, participants showed significant improvements on ADHD-RS (31.12 ± 8.82 at baseline, 24.15 ± 11.45 at endpoint; p < 0.001) and CGI-S (3.38 ± 1.18 at baseline, 2.94 ± 1.00 at endpoint; p < 0.001). On the Continuous Performance Test, commission errors significantly decreased, while reaction time significantly increased. Immediate recall and delayed recall on both Auditory Verbal Learning Test and Complex Figure Test showed significant improvements. Scores of Color−Word Task from Stroop Color−Word Test also showed significant improvements after the treatment. The supplement was well tolerated. Conclusion: The results of this pilot study suggest that the combination of omega-3 and Korean red ginseng may improve ADHD symptoms and cognitive function including attention, memory, and executive function in children with ADHD. Future randomized placebo-controlled trials with a larger sample is warranted.

2012 추계 수자원기술정책 세미나 후기 - 한국하천협회 및 한국수자원학회 MOU 기념

이지원,Lee, Ji-Won 한국하천협회 2013 하천과 문화 Vol.9 No.1

안와골절에서 결막절개를 통한 Medpor 내고정술의 합병증 분석과 치료

이지원,최재일,하원,양완석,Lee, Ji Won,Choi, Jae Il,Ha, Won,Yang, Wan Suk 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.1

Purpose: In accordance to an increased interest in facial appearance and the popularization of computed tomography scanning, the number of diagnosis and treatment of blowout fractures has been increased. The purpose of this article is to review pure blowout fracture surgery through transconjunctival incision focusing on complications and their management. Methods: In this retrospective study, 583 patients, who had been treated for pure blowout fracture through transconjunctival incision from 2000 to 2009, were evaluated. Their hospital records were reviewed according to their sex, age, fracture site, preoperative presentations, time interval between trauma and surgery, and postoperative complications. Results: According to postoperative follow-up results, there were early complications that included wound dehiscence and infection (0.2%), hematoma (insomuch as extraocular movement is limited) (0.7%), lacriminal duct injury (0.5%), and periorbital nerve injury (0.7%). In addition, there were late complications that lasted more than 6 months, that included persistent diplopia (1.7%), extraocular movement limitation (0.9%), enophthalmos (1.0%), periorbital sensation abnormalities (1.0%), and entropion (0.5%). Conclusion: We propose the following guidelines for prevention of postoperative complications: layer by layer closure; bleeding control with the epinephrine gauzes, Tachocomb, and Tisseel; conjunctival incision 2 to 3 mm away from punctum; avoidance of excessive traction; performing surgical decompression and high dose corticosteroid therapy upon confirmation of nerve injury; atraumatic dissection and insertion of Medpor Barrier implant after securing a clear view of posterior ledge; using Medpor block stacking technique and BioSorb FX screw fixation; performing a complete resection of the anterior ethmoidal nerve during medial wall dissection; and making an incision 2 to 3 mm below the tarsal plate.

서지 네트워크의 웹 이용자 서비스 연구

이지원,Lee, Ji-Won 한국비블리아학회 2010 한국비블리아학회지 Vol.21 No.1

검색엔진, 웹 포털사이트, 온라인 서점 등이 정보의 유통을 주도하면서 도서관과 도서관 웹 사이트에서 제공하는 목록의 영향력이 줄어들고 있다. 이러한 환경에서 서지 네트워크 기관에서도 웹 환경의 일반이용자들에 대한 서비스에 더 많은 관심을 갖게 되었다. 본 연구에서는 서지 네트워크의 발전과정, 도서관과 목록 환경의 변화, 차세대 목록 인터페이스와 OPAC 2.0의 모습을 먼저 살펴보았다. 그리고 대표적인 서지 네트워크 기관으로 최근 주목할 만한 변화를 지속적으로 시도하고 있는 OCLC의 사례를 구체적으로 살펴보았다. 이를 바탕으로 웹 이용자 서비스를 중심으로 서지 네트워크의 발전 방향을 세 가지 전략으로 나누어 제시하였다. 본 연구가 서지 네트워크의 발전 방향 설정을 위한 기초자료 뿐만 아니라, 도서관과 목록 서비스의 변화와 개선 전략으로도 참고가 되리라 기대한다. Search engines, web portal sites, online book stores are being the main stream of information network. Library and its catalog has not influenced as the way it had been to the information network any more. Thus, institutions leading the bibliographic network started to pay much attention to the web user service. This article firstly reviewed the development of the bibliographic network, next generation catalog interface and OPAC 2.0, and investigated the case of OCLC in detail. Based on the reviews, this study suggested the development plan of bibliographic network focusing on the web user service in terms of the three strategies. It is hoped that this article will be the basic study for the future of the bibliographic network and the reference for the changes and improvements of libraries and catalog services.