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이종재,유중기,김진경,손우성 한국자기공명학회 2013 Journal of the Korean Magnetic Resonance Society Vol.17 No.1
Immortalization-upregulated protein-1 (IMUP-1) genes have been cloned and are known to be involved in SV40-mediated immortalization. IMUP-1 gene is highly expressed in various cancer cell lines and tumors, suggesting the possibility that they might be involved in tumorigenicity. Previously, there were several problems for overexpression of IMUP-1 in bacterial expression systems including low solubility and aggregation due to unstructured property. To investigate the structural properties, it is necessary to obtain lots of pure and soluble proteins. Accordingly, the co-expression systems of bacterial chaperone proteins, GroEL-GroES, were used to increase solubility of IMUP-1. From the analysis of NMR and CD experiment data, it is suggested that the protein adopt typical the random coil properties in solution.
Identification of Enzymatic Catalysis of PncA using 1H-NMR
이종재,김원제,이진규,임종수,이봉진,손우성 한국자기공명학회 2017 Journal of the Korean Magnetic Resonance Society Vol.21 No.3
Pyrazinamidase (PncA) from Mycobacterium tuberculosis is the hydrolytic enzyme (hydrolase) that can hydrolyze substrate PZA to active form pyrazoic acid (POA). To investigate hydrolytic reaction of M. tuberculosis PncA, 1D NMR spectra were monitored at various molar ratios of PncA and PZA. The line-width of PZA was changed as PncA was added into PZA with different molar ratios. These results suggested that determination of PncA enzymatic activity could potentially serve as an indirect measure of PZA susceptibility.
An Overview of Information Processing Techniques for Structural Health Monitoring of Bridges
이종재,박영수,윤정방,구기영,이진학,Lee, Jong-Jae,Park, Young-Soo,Yun, Chung-Bang,Koo, Ki-Young,Yi, Jin-Hak Computational Structural Engineering Institute of 2008 한국전산구조공학회논문집 Vol.21 No.6
교량 건전성 모니터링은 응답 데이터를 활용한 구조모델링기술, 신호분석, 정보처리 기술의 발전에 따라 손상추정 및 안전성평가와 함께 중요한 연구주제로 부각되었다. 교량 모니터링 시스템은 일반적으로 센서, 데이터 취득장비, 전송시스템 등과 같은 하드웨어와 신호처리, 손상추정, 전시 및 데이터 관리 등과 같은 소프트웨어로 구성된다. 본 논문에서는 교량의 건전도 모니터링을 위한 정보처리기술에 대한 연구 개발 활동을 정리하였다. 교량 건전성 모니터링의 과정에 대한 간단한 소개와 함께, 다양한 신호처리 및 손상추정 알고리즘을 포함한 정보처리기법에 대해서 소개하였다. 현 교량 건전성 모니터링 시스템에서의 주요 문제점과 향후 연구개발활동을 논의하였다. The bridge health monitoring has become an important research topic in conjunction with damage assessment and safety evaluation of structures owing to the improvement of structural modeling techniques incorporating response measurements and the advancements in signal analysis and information processing capabilities. The bridge monitoring systems are generally composed of hardwares such as sensors, data acquisition equipment, data transmission systems, etc, and softwares such as signal processing, damage assessment, display and management, etc. In this paper, the research and development(R&D) activities on the information processing for structural health monitoring of bridges are reviewed. After a brief introduction to the process of bridge health monitoring, various information processing techniques including various signal processing and damage detection algorithms are introduced in detail. Several challenges addressing critical issues in the current bridge health monitoring system and future R&D activities are discussed.