말기 신부전증에 의한 이차성 부갑상선 기능항진증 환자에서 부갑상선 조직의 세포자가사멸 연구

이유미,이재복<SUP>1<,SUP>,Yu Mi Lee,Ph,D and Jae Bok Lee,Ph,D,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.4

Purpose: The cause of renal hyperparathyroidism is unclear and the role of hyperphosphatamia is the only well established cause of renal osteodystrophy. The long life span of the parathyroid cells and the absence of a definite tissue marker for nodular parathyroid gland prohibit the timing of surgical intervention. The discrepancy between proliferation and apoptosis has been proposed as one possible cause of nodular development of the parathyroid gland in patients suffering with renal osteodystrophy. In the present study, we investigated the apoptotic labeling index of the parathyroid tissue in patients with renal hyperparathyroidism. Methods: The parathyroid tissues of 76 patients with renal hyperparathyroidism and those of 33 normal glands were used for determining the level of apoptosis by performing a Tdt-mediated dUTP nick end labeling (TUNEL) assay. The patients' information was collected by a review of the clinical charts. Statistical comparison was done via two tailed t-tests. Results: The averages of the TUNEL indices were 0.19 in the normal parathyroid glands and 1.84 in the hyperplastic parathyroid glands (P=0.00). The TUNEL index was higher in the oxyphil type of cells than in the chief cells and the water clear cell types (P=0.01). There was statistically significant correlation of the TUNEL index with the duration of the dialysis and less than 10 years dialysis showed a 2.23 index, which was higher than that of the longer term dialysis patients (P=0.00). The preoperative PTH level, recurrence, the Ki-67 labeling index and the pathologic type didn't show any statistical correlation with the TUNEL index (P>0.05). Conclusion: Our findings showed that the TUNEL index is useful for separating the cases of advanced renal hyperparathyroidism from the early ones and the TUNEL index is well correlated with hyperplastic types of cells. A decrease of apoptosis could be a probable cause of the progression of parathyroid hyperplasia in renal patients who are on dialysis support. (Korean J Endocrine Surg 2008; 8:250-255)

대학캠퍼스공간에서 여대생이 느끼는 범죄불안감에 관한 연구

이유미,Lee, You-Mi 한국교육시설학회 2013 敎育施設 Vol.20 No.1

This study aims to investigates the female collegian's the fear of crime in university campus. In order to deal with it, the questionnaire survey on the analysis of the female collegian's the fear of crime are conducted in 3 university campuses in Seoul. The results of the 228 questionnaires survey are analyzed in descriptive statistics through SPSS program. This study compares female collegian's the fear with male collegian's one. The result of this are the followings ; 1) The female have the bigger concerns than the male about the crime expected to happen to herself. 2) At night the female are limited in activity than male because of the fear of crime. 3) During day the female have the bigger fear of crime than the male in the space such as stairways and hallways, toilet, and elevator. 4) At night the female have the bigger fear of crime than the male in not only stairways and hallways, toilet, elevator but also pedestrian, green space, recreational space. 5) This study proved the correlation between the collegian's satisfaction about university campus safety and the collegian's satisfaction about university campus environments etc.

산림정보 - 꿈같은 열매 "월귤"

이유미,Lee, Yu-Mi 한국산림경영인협회 2010 山林經營 Vol.197 No.-

In vivo와 in vitro 에서 양극산화 처리한 타이타늄 시편의 상대적인 생체적합성 평가

이유미,이은정,염동선,김도순,이성태,김병일,조현욱,Lee Yu-Mi,Lee Eun-Jung,Yeom Dong-Sun,Kim Do-Soon,Yee Sung-Tae,Kim Byung-Il,Cho Hyun-Wook 한국생명과학회 2006 생명과학회지 Vol.16 No.2

처리하지 않은 타이타늄과 양극 산화 처리한 타이타늄 시편의 생체적합성을 평가하기 위해, 시편을 마우스의 복부 피하 조직에 이식하고 2주 동안 생존시켰다. 그 시편에 대한 복부 피하 결합조직의 반응을 조직학적으로 조사하였다. 시편 주위를 둘러싸는 섬유성 결합조직 막이 관찰되었으며 이 막은 섬유모세포, 섬유세포 및 기타 세포로서 중성호성백혈구, 대식세포, 거대다핵세포 등으로 이루어져 있었다. 시편을 둘러싸는 이 막에 새로이 형성된 혈관이 존재하기도 하였다. 임플란트와 접하는 섬유성 막에 거대다핵세포가 관찰되었다. 섬유성 막에 있는 세포 종류와 막의 두께를 조사하였다. 막에 있는 대부분의 세포는 섬유모세포와 섬유세포이었다. 양극 산화 처리를 하지 않은 타이타늄 시편에 비해 산화 처리를 한 시편을 둘러싸는 섬유성 막의 평균 두께가 더 얇았다. 또한 타이타늄 시편의 생체적합성을 세포 배양법으로 조사하였다. 산화 처리를 한 시편 위에서 배양한 MG-63 세포의 수가 유의하게 증가되었다. 이런 결과들은 in vivo 와 in vitro 실험에서 산화 처리를 한 타이타늄 시편이 생체적합성을 증가시키는데 효과적이라는 것을 말해준다. To evaluate the biocompatibility of untreated and anodized titanium specimens, the specimens were implanted in the subcutaneous tissue of the abdominal region of female mice for two weeks. The reaction of connective tissue to specimens was histologically studied. The implants were encapsulated by fibrous connective. tissue consisting of fibroblast, fibrocyte and other cellss including neutroophil, macrophage and giant multinucleated cell. some newly formed blood vessels were located in the fibrous capsule surrounding the implant. Giant multinucleated cells were observed at the fibrous capsule adjacent to the implant. Kind of cell types and the thickness of fibrous capsules were examined quantitatively. Most of cell types located in the fibrous capsule were fibroblast and fibrocyte. The average thickness of fibrous capsules for the anodized specimens was much thinner than that of the untreated titanium specimen. Biocompatibility of titanium specimens were also studied by using cell culture method. The number of MG-63 cells was significantly increased on the anodized titanium specimens in vitro experiment. Our observations suggest that anodized titanium specimens are more effective for the improvement of biocompatibility in vivo and in vitro.

산림경영: 산림정보 -층층이 달린 꽃송이 따라 은은한 향기

이유미,Lee, Yu-Mi 한국산림경영인협회 2011 山林經營 Vol.199 No.-

산림경영 - 산림정보

이유미,Lee, Yu-Mi 한국산림경영인협회 2012 山林經營 Vol.204 No.-

책갈피산책 - "욕망의 식물학"

이유미,Lee, Yu-Mi 대한출판문화협회 2002 출판저널 Vol.319 No.-

분무열분해법으로 YAG:Ce 제조시 용액 조건이 발광특성에 미치는 영향

이유미,강태원,정경열,Lee, You-Mi,Kang, Tae-Won,Jung, Kyeong-Youl 한국분말야금학회 2012 한국분말재료학회지 (KPMI) Vol.19 No.3

YAG:Ce yellow phosphor particles were synthesized by spray pyrolysis with changing the solution properties and their luminous properties, crystal structure, and morphological changes were studied by using PL measurement, XRD, and SEM analysis. It was clear that the solution properties significantly affected the crystal phase, crystallite size, the PL intensity, and the morphology of YAG:Ce particles. At low calcination temperature, the addition of urea only to the spray solution was helpful to form a pure YAG phase without any impurity phases, as the result, the highest luminescence intensity was achieved at the calcination temperature of $900^{\circ}C$. When the calcination temperatures were larger than $1300^{\circ}C$, however, the YAG particles prepared without any additive showed the highest luminescent intensity. Regardless of the solution conditions, the emission intensity of YAG:Ce particles prepared by spray pyrolysis showed a linear relation with the crystallite size. In terms of the morphology of YAG:Ce particles, the addition of both DCCA and $NH_4OH$ to the spray solution was effective to prepare a spherical and dense structured YAG particles.

인산염의 첨가와 침지가 저지방 소시지의 냉장저장 중 품질과 저장성에 미치는 영향

이유미,진구복,Lee, Yu-Mee,Chin, Koo-Bok 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.1

This study was performed to determine the quality characteristics and shelf-life of low-fat sausages (LFS) with 0.4% sodium tripolyphosphate (STPP) alone or in combination with a 10% trisodium phosphate (TSP) solution during refrigerated storage. When 0.4% STPP was added, no differences in pH values were observed. However, pH values increased with the addition of the TSP solution when 0.4% STPP was incorporated. The addition of STPP into LFS decreased redness and the dipping in the TSP solution increased yellowness (p<0.05). Total bacteria and Listeria monocytogenes, which inoculated Log $10^{3-4}$ colony forming units (CFU/g) were increased with increased storage time. At 4 wk of storage, total bacteria and Listeria monocytogenes reached levels of 8.03-8.22 Log CFU/g, however they decreased to 7.89 Log CFU/g at 8 wk of storage time. Due to the pH increases, Listeria monocytogenes significantly increased in LFS dipping with 10% TSP. Based on these results, LFS dipping with 10% TSP solution promoted the growth of Listeria monocytogenes, regardless of STPP addition. These results indicated that 0.4% STPP addition and dipping with TSP affected the pH and color, however, it didn't extend the shelf-life of LFSs during refrigerated storage. 본 연구는 인산염의 첨가와 침지가 저지방 소시지의 저장기간에 따른 품질 및 저장성을 평가하기 위해 실시하였다. 저지방 소시지에 0.4% STPP를 첨가하고, 10% TSP 용액에 침지함에 따라 pH값이 증가하였다. STPP의 첨가에 따라 적색도가 감소하는 반면, 10% TSP 침지구의 황색도는 증가하였다(p<0.05). 저장기간이 경과함에 따라 명도는 유의적으로 감소한 반면 적색도는 유의적으로 증가하였다(p<0.05). 약 5 Log CFU/g로 접종된 Listeria monocytogenes(LM) 균수는 저장기간이 경과함에 따라 4주에 8.03-8.22 Log CFU/g로 나타났고 8주에는 7.89 Log CFU/g로 약간 감소했다. 접종된 저지방 소시지의 저장 중 총균과 LM균의 성장은 10%의 TSP 침지에 의해 pH의 증가로 유의적으로 더 촉진된 것으로 판단된다. 이와 같은 결과를 종합하면 인산염 첨가 및 침지는 pH와 색도(명도와 황색도)에 영향을 주었으며 저장기간 중 뚜렷한 항균 및 항산화 효과는 없었다.

수면의 질과 구강 안면 통증의 관계

이유미,Lee, You-Mee 대한안면통증구강내과학회 2006 Journal of Oral Medicine and Pain Vol.31 No.1

This study was performed to investigate about sleep quality and orofacial pain pattern between experimental and control group. 101 subjects with temporomandibular disorders without any psychologic and neurologic problem were selected from the patients presented to Wonkwang University dental hospital. Routine clinical examination for TMD was carried out, especially for the frequency of headache and the craniocervical muscles were also done by the author in the first visit. All the subjects filled out the questionnaires, that was, for the evaluation of sleep quality using Pittsburgh sleep quality index(PSQI), and for the analysis of behavioral pain scale questionnaires. Data obtained were statistically processed by the SPSS Windows program and the results of this study were as follows: 1. Subjective sleep index, sleep latency, sleep disturbance, global score in control group were significantly lower than 2. Subjective sleep index, sleep disturbance, global score in subject with headache were significantly lower than subject without headache(P<0.05). 3. Medicine taker have sleeping drug. Caffeine drinkers was significantly higher in daytime dysfunction, global score than no drinker. 4. It have more frequent head and neck pain, pain spreading, daily life difficult in poor sleeper than good sleeper.