지리산국립공원의 낙동강 수계 하천 유역에 서식하는 수달(Lutralutra)과 족제비(Mustela sibirica coreana)의 분 분석

이수일 ( Su Ill Lee ),손성원 ( Sung Won Son ) 경남대학교 기초과학연구소 2003 기초과학지 Vol.17 No.-

Helicobacter pylori 감염의 유병률과 관련요인에 관한 연구

김영욱,이수일,조병만,고광욱,김영실,강수용,차애리,김돈균,Kim, Yeung-Wook,Lee, Su-Ill,Cho, Byung-Mann,Koh, Kwang-Wook,Kim, Young-Sil,Kang, Su-Yong,Cha, Oae-Ri,Kim, Don-Kyoun 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.3

Helicobacter pylori 감염은 만성 위염과 소화성 궤양의 원인인자로 작용하며 위암과도 강한 상관관계가 있는 것으로 증명되어 기존의 위 십이지장 질환의 치료와 관리에 많은 변화를 가져오고 있다. 저자들은 Helicobacter pylori 감염의 유병률을 측정하고 유병상태와 관련되는 요인을 조사할 목적으로 부산광역시와 경상남도에 거주하는 소아 몇 청년 552명을 대상으로 1996년 4월부터 6월에 걸쳐 본 연구를 시행했다. 연구 대상자들의 혈청에 존재하는 Helicobacter pylori Ig G 항체는 Enzyme Linked Immunosorbent Assay(ELISA) 방법으로 측정했으며 설문조사를 통해 기본적인 인구학적 특성, 유병상태와 관련되는 요인에 관한 정보를 얻었다. 연구 대상자들의 총 Helicobacter pylori 감염률은 25.7%였고 $1\sim3$세군에서의 5.8%에서 $20\sim29$세군의 44.4%까지 연령이 증가함에 따라 유병률도 비례해 증가하는 양상을 보였다($\chi^2$ for trend=57.9, p<0.0001). 특히 학동기 전 연령인 $4\sim6$세 군에서 초등학교 1, 2, 3학년 연령인 $7\sim9$세 군간에 유병률의 급격한 상승이 관찰되어 이 시기에 Helicobacter pylori 감염이 본격적으로 발생하는 것으로 추측된다. 다변량 로지스틱 회귀 모델에서 연령, 가족수 및 거주하는 주택의 형태가 유병상태와 유의한 상관관계를 보였으며 각각의 교차비(95% 신뢰구간)는 연령 $1\sim9$세를 기준으로 $10\sim19$세 $3.6(2.0\sim6.4)$, $20\sim29$세 $7.3(4.1\sim13.1)$ 였고, 가족수 $1\sim3$명을 기준으로 $4\sim5$명 $2.1(1.3\sim5.4)$, 6명 이상 $2.7(1.3\sim5.4)$였으며 주택의 형태는 아파트 거주를 기준으로 일반주택 및 연립주택 $1.9(1.1\sim3.5)$ 이었다. Helicobacter pylori is now recognized as causative agent of chronic gastritis and peptic ulcer, and strongly associated with development of gastric carcinoma. With development of sensitive and specific serologic tests to identify individuals infected with Helicobacter pylori, the epidemiologic study of this diseases has been investigated. But it's transmission route is not established, yet. The purpose of this study is to measure the prevalence of Helicobacter pylori infection in healthy children and young adults and to evaluate related factors for Helicobacter pylori infection in Korea. The seroprevalence of Ig G antibodies to Helicobacter pylori was determined using a Enzyme Linked Immunosorbent Assay and we obtained the information, such as demographic characteristics, monthly household income, numbers of family members in the house, numbers of persons using same room, type of house, and type of drinking water through the questionnaire survey. The observed overall seropositivity rate was 25.7%. The rate is increased progressively from 5.8% in the age group $1\sim3$ years to 44.4% in the age group $20\sim29$years($\chi^2$ for trend, p<0.001). Especially, the rate increased steeply from 6.5% in the age group $4\sim6$ years to 20.8% in the age group $7\sim9$ years, and this suggested that elementary school age was the major acquisition time of Helicobacter pylori infection. In multivariate logistic regression model, age, numbers of family members in the house, and type of house was statistically significant variables for Helicobacter pylori infection. Each odds ratio(93% CI) were as follows; base to age group $1\sim9$ years, age group $10\sim19$ years $3.6(2.0\sim6.4)$, age group $20\sim29$ years $7.3(4.1\sim13.1)$ and base to group of $1\sim3$ family members, group of $4\sim5$ family members $2.1(1.1\sim4.0)$, group of 6 or more family members $2.7(1.3\sim5.4)$ and base to apartment, single and multihouse $1.9(1.1\sim3.5)$. Sex, monthly household income, numbers of persons using same room, and type of drinking water was not statistically significant for Helicobacter pylori infection.

부산지역 거주 노인의 인지기능장애 및 치매 유병률

김정순,이수일,정영인,황인경,이봉숙,김민정,초의수,전진호,정인숙,Kim, Jung-Soon,Lee, Su-Ill,Chung, Young-In,Hwang, In-Kyung,Yih, Bong-Sook,Kim, Min-Jeong,Cho, Eu-Soo,Chun, Jin-Ho,Jeong, Ihn-Sook 대한예방의학회 2003 예방의학회지 Vol.36 No.1

Objectives : To investigate the prevalence of cognitive impairment and dementia in elderly people, aged 65 or above, residing in Busan Metropolitan City. Methods : Total of 1,101 old people, aged 65 or above, living in Busan as of December 31, 2001 were selected using stratified three-stage cluster sampling. Cognitive impairment was determined from the MMSE-K score, and dementia confirmed from five psychometric measures and the Barthel index. The crude prevalence, sex-age adjusted for the Korean population, were obtained. Results : With the cut-off point for cognitive impairment was set at 24 points, or below, on the MMSE-K scale, the crude rate of cognitive impairment was 29.3% (15.7% for men and 37.5% for women), and the sex-age adjusted prevalence was 30.5% (17.5% for men and 37.0% for women). When the cut-off point for cognitive impairment was set at 20 points, or below, on the MMSE-K scale, the crude rate of cognitive impairments were 10.0% (4.1% for men and 13.5% for women), and 10.6% (4.7% for men and 13.1% for women), respectively. The crude dementia, and the sex-age adjusted rates were 7.4% (2.4% for men and 10.5% for women), and 8.0% (2.7% for men and 10.0% for women), respectively. Conclusions : The prevalence of dementia in this study was somewhat lower than that reported by other domestic and foreign studies. Our results related to the difference in time and space, diagnostic tools, response rates, and distribution of male and female subjects, etc.

부산지역 일부 소아의 혈청 지질 분포에 관한 연구

강수용,조병만,이수일,황인경,김영욱,김영실,차애리,하이호,이철호,김돈균,Kang, Soo-Yong,Cho, Byung-Mann,Lee, Su-Ill,Hwang, In-Kyong,Kim, Yeung-Wook,Kim, Young-Sil,Cha, Ae-Ri,Ha, I-Ho,Lee, Chel-Ho,Kim, Don-Kyoun 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.4

This is a cross-sectional study to evaluate the serum lipid levels of children living in Pusan in 1996. The distribution of age is from 2 years old to 12 years old. In female children mean total cholesterol is $171.4{\pm}26.2mg/dl$, triglyceride is $104.7{\pm}50.6mg/dl$, HDL-cholesterol is $54.4{\pm}14.8mg/dl$, and LDL-cholesterol is $95.4{\pm}32.9mg/dl$. In male children mean total cholesterol is $167.9{\pm}25.2mg/dl$, triglyceride is $6{\pm}45.5mg/dl$, HDL-cholesterol is $55.4{\pm}11.7mg/dl$, and LDL-cholesterol is $94.4{\pm}23.6mg/dl$. The percentile of serum lipid levels is measured in children. The 95th percentile of serum total cholesterol is 210mg/d1 in male children, and 214mg/d1 in female children. And, the 95th percentile of serum triglyceride is 184mg/d1 in male children, and 191mg/d1 in female children. And, the 95th percentile of LDL-cholesterol is 133mg/d1 in male children, and 135mg/d1 in female children. Serum total cholesterol is positively .Elated to age(r=0.18), height(r=0.08), weight (r=0.17), obesity index(r=0.12), and negatively .elated to father's education level (r=-0.13), mother's education level(r=-0.13). Serum triglyceride is positively related to weight(r=0.23), age(r=0.31) and negatively .elated to father's education level(r=-0.12), mother's education level(r=-0.18). Serum HDL-C was positively reated to mother's education level(r=0.07) and negatively .elated to height(r=-0.12), weight(r=-0.09). Conclusively, the serum lipid levels of children living in Pusan is generally so high that the family and school must try to control the serum lipid levels. 본 연구는 부산지역 소아의 연령별 혈청지질치의 분포와 이에 영향을 미치는 요인에 대한 단면조사연구로서 1996년 4월에 2세부터 12세의 941명을 대상으로 혈청 지질을 조사한 결과는 다음과 같다. 1. 평균 혈청지질치 혈청지질치는 여아의 경우 총콜레스테롤 $171.4{\pm}26.2mg/dl$, 중성지방 $104.7{\pm}50.6mg/dl,\;LDL-C\;95.4{\pm}32.9mg/dl$로 남아의 $167.9{\pm}25.2mg/dl,\;90.6{\pm}45.5mg/dl,\;94.4{\pm}23.6mg/dl$보다 높았다. 총콜레스테롤 (p<0.05)과 중성지방(p<0.01)에서는 여아에서 통계적으로 유의하게 높았다. HDL-C은 남아가 $55.4{\pm}11.7mg/dl$로 여아의 $54.4{\pm}14.8mg/dl$보다 높았다. 2. 혈청지질치의 백분위수 소아의 혈청지질치의 백분위수는 총콜레스테롤의 경우 95퍼센타일이 남아에서 210mg/dl, 여아의 경우 214mg/d1로 미국에서 보고된 남아의 191mg/dl과 여아의 209mg/dl보다 오히려 높았다. 3. 혈청 지질과 비만도 경도 비만군과 중등도 비만군이 정상군보다 총콜레스테롤, 중성지방, LDL-C 등에서 의미있게 높았고, HDL-C에서 의미있게 낮았다(p<0.05). 4. 혈청 지질과 부모의 학력 총콜레스테롤, 중성지방, LDL-C은 아버지의 최종학력이 높을수록 의미 있게 감소하였고(p<0.05), 총콜레스테롤, 중성지방, LDL-C은 어머니의 최종학력이 높을수록 의미 있게 감소하였고(p<0.01), HDL-C은 어머니의 최종학력이 높을수록 통계학적으로 의미있게 증가하였다(p<0.05).

일부 농촌지역 노인들의 인지 장애에 관련된 요인에 관한 연구

고광욱,조병만,이수일,김돈균,조봉수,김영욱,김영실,강수용,Koh, Kwang-Wook,Cho, Byung-Mann,Lee, Su-Ill,Kim, Don-Kyoun,Cho, Bong-Su,Kim, Yeung-Wook,Kim, Young-Sil,Kang, Su-Yong 대한예방의학회 1996 예방의학회지 Vol.29 No.3

경상남도 일부 지역에서 60세 이상 노인들의 MMSE에 의한 인지 장애 유병률을 조사하고 인지 장애에 영향을 미치는 요인들을 조사하여 다음과 같은 성적을 얻었다. 1. MMSE에 의한 인지 장애의 유병률은 35.9%로 남자에서 18.4%, 여자에서 45.2%였다. 2. 인지 장애 유병률은 여자에서 유의하게 높았고(p=0.02) 무학력자와 문맹자의 인지 장애 유병률이 통계적으로 유의하게 높았다(p=0.03). 3.성별과 교육 수준에 따른 층화 분석에서 알루미늄의 인지 기능에 대한 독성 효과와 칼슘의 보호 효과에 대한 전체적으로 일정한 경향은 관찰되지 않았다(p>0.05). 4. 최종 분석 대상자 전체에서 음용수 중의 알루미늄과 인지 기능 검사 점수간의 상관 계수는 -0.066으로서 미약한 음의 상관관계에 있었으나 통계학적인 유의성은 보이지 않았고(p=0.434), 칼슘과 MMSE 점수와의 관계에서도 기대했던 바의 양의 상관관계는 관찰할 수 없었다. To investigate the factors which affecting the cognitive impairment of the 60 or more age group, the authors surveyed for the subjects in some area of Kyungnam Province. 201 studied subjects were tested for cognitive function with mini-mental state examination(MMSE). Information on demographic characteristics and life style has been collected through direct interview. The concentration of Ai and Ca of subject's drinking water, which might be related with cognition, was measured by Inductively Coupled Argon Plasma Spectrometer. The main results were summarized as follows. 1. The prevalence rate of cognitive impairment was 18.4% in male and 45.2% in female and this sexual difference was statistically significant(p=0.03). And the uneducated or illiterated showed significantly high prevalence rate of cognitive impairment(p=0.02). 2. In stratified analysis by sex md education year, we can not see significant trend indicating the neurotoxic effects of aluminum and protective effects of calcium to the cognitive function(p>0.05). 3. The correlation between the concentration of aluminum in drinking water and the MMSE score in whole subjects showed weak negative relationship(r=-0.066). But there was no statistical significance(p=0.434).

일부 도시 영세지역 노인들의 영양상태와 관련인자에 관한 연구

조봉수,김돈균,이수일,조병만,김영욱,고광욱,Cho, Bong-Soo,Kim, Don-Kyoun,Lee, Su-Ill,Cho, Byung-Mann,Kim, Young-Ook,Koh, Kwang-Wook 대한예방의학회 1995 예방의학회지 Vol.28 No.1

부산시 해운대구 반송2동 운봉 영구임대 아파트에 거주하는 60세 이상의 노인 135명 (남자 36명, 여자 99명), 기타 지역에 거주하는 일반가정의 60세 이상 노인 136명(남자 45명, 여자 91명)을 대상으로 1994년 3월부터 8월까지 6개월에 걸쳐 영양섭취 상태 및 관련 요인들을 분석한 결과를 요약하면 다음과 같다. 1. 대상자의 일반특징 두 지역에서 성별 분포와 연령의 평균치에는 차이가 없었으며 소득수준의 경우 유의한 차이가 있어서 대상지역이 영세지역을 나타내고 대조지역이 일반가정을 나타낸다는 가정은 충족되었다. 2. 영양섭취에 관련된 요인 지난 한 해 동안의 입원 여부나 위장관계 질환, 음주, 흡연은 유의한 차이가 없었으나 만성질환, 투약, 비타민제 복용, 건강인식상태 등은 유의한 차이를 보여 일부 요인에 있어 대상지역의 건강관련상태가 더 나쁜 것으로 나타났다. 3. 영양소 섭취 상태 일부 항목은 권장량을 초과하는 것도 있으나 대부분의 영양소는 섭취량이 부족하였고, 더욱이 대조지역과 비교할 때 영양상태가 유의하게 낮아 소득수준을 포함한 경제수준의 차이가 영양상태를 나타낸다는 가설을 증명할 수 있었다. 4. 식생활 관련 지식과 행동 식생활관련 지식의 경우 유의하게 대상지역이 낮았으나 행동의 경우 큰 차이가 없었다. 이는 소득 수준이 행동에 영향을 준다고 가정한 가설에 어긋나는 결과로 교육수준 등 다른 교란변수들이 미치는 영향이 더 큰 것으로 볼 수 있었다. 5. 영양소 섭취에 영향을 미치는 인자 영양소 섭취에 영향을 미치는 주된 인자는 교육과 소득, 식생활 관련 지식이었으며, 대상지역의 경우 식생활 관련 지식이 영양섭취에 영향을 미쳐, 영양상태의 개선을 위해 영세지역의 노인들을 대상으로 한 올바른 식지식에 대한 교육이 필요할 것으로 생각된다. This study was carried out to analyze the food intake and associated factors of the urban poor elderly by comparing poor district, Unbong rental apartment in Bansong 2 dong with other areas in Pusan. 135 elderlies(men 36, women 99) in Unbong rental apartment, 136 elderlies(men 45, women 91) in the other areas were investigated during the period of March to August in 1994. The assumption that the study area represented poor district was satisfied because the age and sex distribution was not significantly different, and the income of the study area was significantly lower than that of the control area. The variables of hospitalized in previous 12 month, gastrointestinal problem, alcohol drinking, cigarette smoking did not differ significantly. But the variables of chronic disease, take medicine, perceived health, vitamin supplement differed significantly between two groups. Therefore some factors associated with health state in the study area are worse than those of the control area. At most of all variables, nutrients intake of the study area did not reach the recommended dietary allowances(RDA) for Koreans, and that nutrient intakes of the study area were significantly lower than those of the control area. The hypothesis of this study that nutrient status depends on economical status was proved. As for the score of nutritional knowledge, the study area was significantly lower than the control area. But as for the score of nutritional behavior, two areas were not significantly different. The latter is counter result of our hypothesis, owing to the effect of the confounding factors including education etc. As for the correlation of variables, not only economic status and educational level, but the score of nutritional knowledge effects strongly on nutrient status in the study area, the poor district. Therefore, adequate nutritional education to the elderly in e poor district should be considered.

부산 일부지역 근로자들의 재해성 요부손상에 대한 사회의학적 조사

박종욱,김돈균,이수일,조병만,조봉수,김영욱,Park, Jong-Ook,Kim, Don-Kyoun,Lee, Su-Ill,Cho, Byung-Mann,Cho, Bong-Soo,Kim, Young-Wook 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.2

This survey was performed to obtain the basic information for the prevention and management of occupational low back injury (LBI). The subjects of this survey were 952 workers (male, 892 ; female, 60) who had taken occupational LBI in some industries of Pusan area from January 1 to December 31, 1991. Observation period was 2.6 years from the beginning to the end of medical treatment. The obtained results were summarized as follows ; 1. The proportion of LBI workers was 15.9% of the workers who had taken any occpational injuries and 0.32% of all workers in this surveyed area. 2. 8.0% of the workers had taken LBI on the 1st day of employment and 55.2% of the workers were within one year, 91.4% of the workers were within 10 years according to cumulative frequency distribution. 3. Handling of heavy objects was the most common cause of LBI (32.0%) and fall down (26.9%) and slip down (16.3%) were the next in order. 4. The most common causes of both lumbar sprain and HNP were handling of heavy objects and that of lumbar fracture was fall down. 5. The mean duration for medical treatment of LBI workers was 143 days. 6. The total direct compensation cost for LBI workers was 6,736 million Won and the proportion of medical, resting, disability compensation costs were 25.0%, 37.0%, 38.0 % respectively. 7. The percentages of retreated workers and disabled workers were 11.9% (113 persons) and 22.9% (218 persons) of total LBI workers respectively.

방사선취급 병원근무자들의 염색체이상 및 자매염색분체교환 빈도

차애리,김미선,황인경,이수일,조병만,김돈균,Cha, Ae-Ri,Kim, Mi-Sun,Hwang, In-Kyung,Lee, Su-Ill,Cho, Byung-Mann,Kim, Don-Kyoun 대한예방의학회 1998 예방의학회지 Vol.31 No.4

In order to evaluate the cytogenetic hazard among hospital workers potentially exposed to low dose of radiation, the analysis of chromosome aberrations(CA) and sister chromatid exchanges(SCE) in lymphocytes were performed in 79 hospital workers and 79 non-exposed workers. The mean frequency of chromosomal exchange and deletion(respectively, $0.20\times10^{-2}/cell\;and\;0.39\times10^{-2}/cell$) in the exposed group were significantly higher than those$(0.07\times10^{-2}/cell\;and\;0.23\times10^{-2}/cell)$ in control group. The frequency of sister chromatid exchanges was 5.04/cell in the control vs. 6.57/cell in the exposed group. There were also significant differences in the mean frequencies of CA and SCE adjusted for age, sex, smoking, drinking between two groups. There were no evidence of significant increase of CA and SCE according to the department or duration of employment. But the frequency of cells having chromosome aberration was significantly higher in the exposed group than in the control group related to duration of employment. There was no dose-effect relationship between the cumulative doses and the frequency of CA and SCE. But in the case of last 1 yr cumulative dose, there were evidence of significant dose-dependant increase of chromosome type CA and percentage of cells with aberration. The result suggest that there is cytogenetic hazard in risk group like hospital workers handling low dose radiation. And the analysis CA and SCE are useful biological indicators for the exposure of low dose level of radiation.

부산지역 일부사업장 근로자의 요부손상에 대한 역학적 조사연구

김상욱(Sang Wook Kim),서정탁(Jeung Tak Suh),이수일(Su Ill Lee) 대한정형외과학회 1994 대한정형외과학회지 Vol.29 No.7

작업 중 에너지 소모량 평가를 위한 Energy Expenditure Prediction Program의 타당도

강동묵(Dong Mug Kang),우지훈(Ji-Hoon Woo),전진숙(Jin-Sook Jun),이용환(Yong-Hwan Lee),조병만(Byung Mann Cho),이수일(Su Ill Lee) 대한직업환경의학회 2004 대한직업환경의학회지 Vol.16 No.3