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이문수,조숙행,Lee, Moon-Soo,Joe, Sook-Haeng 한국정신신체의학회 2007 정신신체의학 Vol.15 No.2
정신과에 내원하는 환자들 중에서 피로를 호소하는 환자들의 비율이 높으며, 만성적인 피로감을 호소하는 환자들에서 다른 우울증과 같은 정신과질환이 공존하는 경우도 많다. 환자들은 많은 괴로움을 호소하나, 기저의 임상상태의 종류와 심각도에 대해서는 비특이적이므로 실제로는 임상가에 의해서 무시되는 경우가 많으며, 그 중요성이 과소평가되는 경우가 많아서, 적절한 처치를 받지 못하고 삶의 질에도 많은 영향을 받게 된다. 피로는 말초와 중추신경계 둘 다에서 영향을 받는 다차원적인 현상으로 이해하여야 한다. 환자가 호소하는 피로증상에 대해서 좀 더 적극적으로 조절하기 위한 여러 약물학적 및 비약물학적 접근법들이 시도되고 있다. Fatigue is a significant problem in health care. The relationship between chronic fatigue and psychiatric disorders has generated significant interest in recent years. Increased rates of psychiatric disorder among individuals with chronic fatigue have been reported. Fatigue may be defined as physical and/or mental weariness resulting from exertion. The cause of fatigue is complex, influenced by events occurring in both the periphery and the central nervous system. Because fatigue may result from a number of causes, it should be treated comprehensively. The treatment is largely symptomatic and rehabilitative.
Gas chromatography-Thermal Energy Analyzer에 의한 휘발성 니트로소아민과 담배 특유의 니트로소아민들의 동시 분석연구
이문수,지상운,박영수,Rhee, Mun-Su,Ji, Sang-Woon,Park, Yang-Su 한국연초학회 1993 한국연초학회지 Vol.15 No.2
This is to investigate the methodology for the simultaneous determination of Wk, mk and TSNA using gas chromatography(GC) in combination with chemiluminescence detector, thermal energy analyzer(TEA) . The simultaneous analysis has been estimated by evaluating tobacco. The TEA was linked to GC equipped with non -polar SPB -5 fused silica capillary column which was introduced into the ceramic pyrolysis tube by the point of 16cm from the end of TEA. Quantification was carried out by internal standardization with WDPA after calibration of retention times and response factors with authentic nitrosoamines. It was demonstrated that WDPA was most preferable as internal standard for the simultaneous analysis. The recoveries of the internal standard were in the range of 83∼96% . Nitrosoamines in this method were detected with determination limit of 0.1ng and was made by a straight line in calibration curve by TEA response. The suitability of nitrosoamines extraction in tobacco leaf was investigated. It was most suitable to extract nitrosoamines from tobacco leaves with 0.01 M NaOH within a period of 8 hours. Thimerosal as an antibacterial agent was added to NaOH solution to prevent artifactual formation. The fractionation and the purification of nitrosoamines form alkaline extracts were conveniently performed using Extrelut multilayer column and dichloromethane. Reproducible and reliable results were obtained for the determination of nitrosamines in a relatively short time compared to previous known method. TSNA contents in burley were about 4 times higher as those in the fluecured tobacco.
이문수,장기철,지상운,Rhee, Mun-Su,Jang, Gi-Cheol,Ji, Sang-Un 한국연초학회 1993 한국연초학회지 Vol.15 No.1
Nitric oxide of gas phase in cigarette smoke was conveniently determined by Chemiluminescence NO analyzer with 20 ports rotary type smoking machine Data are presented to support this observation. On the basis of this method the amount of NO in the smoke from nonblended and commercial cigarettes were estimated. Gas phase NO concentration in main stream smoke was correlated well with the nitrate levels in tobacco leaves, but there was no correlation with the tar yields. In consequence, it would be considered that the methodology in this study provided simple and rapid quantification for NO in cigarette smoke.
Environmental Tobacco Smoke의 이화학적 특성
이문수 한국연초학회 1995 한국연초학회지 Vol.17 No.1
On the basis of the literature, which is at present still scientific information improvable, the results of research done so far into the occurrence and analytical methodology of major markers of environmental tobacco smoke(ETS) have been summarized. Key areas addressed are: differences in physicochemical composition between mainstream smoke, sidestream smoke and ETS: techniques for field measurement of ETS: relationship between indoor air quality with ETS and its distribution view of US EPA and its problems: biological effects and concerning estimation of ETS exposure.
환경이 조절되는 Chamber 내에서 Environmental Tobacco Smoke의 생성과 감소 현상
이문수,나도영,안기영,이규서 한국연초학회 1996 한국연초학회지 Vol.18 No.2
This paper describes the generation and decay phenomena of gas, vapor and particulate phase components of environmental tobacco smoke in 18 m3 controlled experimental atmosphere chamber. Real time-weighted average concentration ratios of markers were determinated at no ventilation rates and sampling durations of starting to smoking 45 min. Average concentration of major ETS markers was no significant on the mainstream smoke contents of commercial cigarette and decay ratios were dependent on first order kinetic. RSP/nicotine, solanesol and 3-EP were good predictors of ETS concentration in the public indoor field. The concentration ratio of vapor phase and particulate phase components is highly variable to assessment of indoor air quality with ETS. Key words : ETS, chamber study, ETS markers.