http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
가임기 전신성 홍반성 루푸스 환자의 혈청 DHEAS치에 관한 연구
윤진혁 ( Jin Hyuk Yun ),유승훈 ( Seung Hoon Ryu ),정원택 ( Won Tec Jung ),이성원 ( Sung Won Lee ),안원석 ( Won Suk An ),이혁 ( Hyuck Lee ),손춘희 ( Choon Hee Son ),김성은 ( Seong Eun Kim ),김덕규 ( Duk Gyu Kim ),정원태 ( Won Tae 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.2
Objective: Dehydroepiandrosterone sulphate (DHEAS), the major steroidal product of the human adrenal, is abnormally low in patients with SLE. Moreover, a recent study confirms a positive effect of the precursor DHEA on the disease course in SLE, which supports an etiologically important role of the hormone on SLE. The aim of this study is to search for an interrelation between clinical manifestations, laboratory findings, and disease activities and DHEAS in patients with SLE. Method: DHEAS were measured by radioimmunoassay kit using 125I-labeled DHEA-SO4 antibody-coated tube in the serum of 48 patients with SLE and in 46 control subjects. Laboratory findings, clinical symptoms, signs and SLE disease activity index (SLEDAI) in SLE patients were evaluated at blood sampling time. Results: DHEAS was lower in patients with SLE compared to controls (45.60±42.62 μg/dL vs 101.55±56.54 μg/dL, p<0.005). The serum DHEAS levels were significantly negative correlation with SLEDAI (r=-0.333, p<0.05). There were significantly negative correlations between daily steroid dose and DHEAS (r=-0.384, p=0.012), and the amount of steroid used during previous 2 months and DHEAS (r=-0.011, p=0.011). Conclusions: Patients with SLE have low levels of DHEAS and significant negative correlation between SLEDAI, steroid dose and DHEAS.
정원택 ( Won Tec Jung ),윤진혁 ( Jin Hyuk Yun ),문희건 ( Hee Kun Moon ),김병희 ( Byung Hee Kim ),유승훈 ( Seung Hoon Ryu ),이창민 ( Chang Min Lee ),김경희 ( Kyeong Hee Kim ),권혁찬 ( Hyuk Chan Kwon ),이성원 ( Sung Won Lee ),정원태 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Rheumatoid arthritis (RA) is though to be a collagen disease induced by auto-immune mechanism of unknown etiology. Chronic myelogenous leukemia (CML) is a disease characterized by overproduction of cells of the granulocytic, especially the neutrophilic series and occasionally the monocytic series, leading to marked splenomegaly and very high white blood cell counts. There`s no consensus on the risk of leukemia in RA. There are some reports ragarding the relationship between low dose of methotrexate (<20 mg weekly) and the development of leukemia in RA. Although RA is a complex process, it can be considered initially as a stem cell disorder requiring treatment similar to that administered to transplant patient. We experienced a case of CML associated with RA. A 60-year-old woman with RA was treated with low dose methotrexate (7.5 mg weekly), hydroxychloroquine (HCQ), non-steroidal anti-inflammatory drug (NSAID) and low dose steroid. This therapy was continued for 3 years. She was diagnosed CML after 3 years of therapy. CML was confirmed by bone marrow biopsy and the presence of the Philadelphia chromosome.
유승훈 ( Seung Hoon Ryu ),윤진혁 ( Jin Hyuk Yun ),정원택 ( Won Tec Jung ),박은희 ( Eun Hee Park ),권혁찬 ( Hyuk Chan Kwon ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3
Cryoglobulins are cold-precipitable monoclonal or polyclonal immunoglobulins, which can occur without an identifiable underlying disease condition or in association with underlying disorders. Cryoglobulinemic vasculitis is immune complex-mediated vasculitis that predominantly affect small vessels. Less often, medium-sized or even large vessels can be affected. Cryoglobulinemic vasculitis is a rare one of the cutaneous manifestations of multiple myeloma. We experienced a patient with cryoglobulinemic vasculitis developed in multiple myeloma who presented with Raynaud`s phenomenon, purpuric patch and skin ulcer.
금동주 ( Dong Joo Keum ),양두경 ( Doo Kyoung Yang ),김광진 ( Kwang Jin Kim ),지삼룡 ( Sam Ryong Jee ),윤진혁 ( Chin Hyuk Yun ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
Behcet`s disease is a recurring illness characterized by the triple symptom complex of aphthous stomatitis, genital ulceration, and uveitis. The disease is multisystemic disorder with involvement of skin, gastrointestinal tract, blood vessels, central nervous system, joints, and epididymis. Vascular involvement of Behcet`s disease affects both arteries and veins and blood vessels of all sizes. Periosteal new bone formation is one feature of hypertrophic osteoarthropathy. Other features are clubbing and arthritis. Periosteal new bone formation on the bones of the lower extremities without other features of hypertrophic osteoarthropathy has been reported in patients with varicose veins, vitamin A intoxication, infantile cortical hyperostosis, tuberous sclerosis, congenital syphilis and chronic renal failure with hyperparathyroidism, and chronic venous insufficiency. However, periosteal new bone formation has not, to our knowledge, been described in patients with Behcet`s disease yet although similar findings are occasionally noted in polyarteritis nodosa. We report a case of Behcet`s disease complicated by leg swelling with periosteal new bone formation of right lower leg.
논문 : 도시 하천에서의 어류 폐사 원인 분석 2 - 자동수질측정장치 및 수질모델의 사용
이은형 ( Eun Hyoung Lee ),서동일 ( Dong Il Seo ),황현동 ( Hyun Dong Hwang ),윤진혁 ( Jin Hyuk Yun ),최재훈 ( Jae Hun Choi ) 대한상하수도학회 2006 상하수도학회지 Vol.20 No.4
This study focused on the causes of fish kills and its prevention methods in Yudeung Stream, Daejeon, Korea. Intense field data, continuous water quality monitoring system and water quality modeling were applied to analyze the causes. Pollutant can be delivered to urban streams by surface runoff and combined sewer overflows in rainfall events. However, water quality analysis and water quality modeling results indicate that the abrupt fish kills in the Yudeung stream seems to be caused by combined effect of DO depletion, increase in turbidity and other toxic material. Excessive fish population in the study area may harm the aesthetic value of the stream and also has greater potential for massive fish kills. It is suggested to implement methods to reduce delivery of pollutants to the stream not only to prevent fish kills but also to keep balance of ecosystem including human uses. Frequent clean up of the urban surface and CSO, installation of detention basin will be helpful. In the long run, it seems combined sewer system has be replaced with separate sewer system for more effective pollutant removal in the urban area.