http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
윤자복,성원진,정명희,민양기 대한비과학회 2002 Journal of rhinology Vol.9 No.1
Background and Objectives:Aloe is one of the well known substances to decrease inflammation and promote woundhealing. Although little is known about its mechanism, recent studies suggest that aloe vera extracts may have the anti-allergiceffect by inhibiting the mediator release evoked by mast cell activation. Therefore, we were to investigate the effect of NY945, aglycoprotein fraction of Aloe vera, on nasal mucosa of the ovalbumin (OVA) sensitized guinea pigs. Materials and Methods:Female Dunkin-Hartley guinea pigs were sensitized with intraperitoneal injection and subsequent inhalation of OVA. NY945was injected intraperitonealy before intranasal challenge of OVA with an ultrasonic nebulizer. Airway resistance, mucosalpermeability, histamine concentration in the nasal lavage fluid, the number of mast cells and eosinophils in nasal mucosa andserum level of OVA -specific IgE were evaluated. Results:NY945 effectively inhibited respiratory airway resistance in thesensitized guinea pigs. The concentration of dye into nasal lavage fluid was rapidly increased after OVA instillation and NY945inhibited the OVA -induced microvascular dye leakage. OVA inhalation to sensitized guinea pig resulted in prominent increase ofhistamine concentration in the nasal lavage fluid. This response was inhibited by intraperitoneal NY945 injection. It alsoinhibited accumulation of eosinophils in the nasal mucosa in sensitized guinea pigs. However, there was no change in the serumOVA -specific IgE level between the NY945 treated and control group. Conclusion:The data suggest that NY945 inhibitsearly allergic reaction via inhibition of histamine release and eosinophil infiltration.
사람에서 유발시킨 구개인두부전증의 비음도와 음향학적 분석
윤자복,성명훈,정원호,김광현 대한후두음성언어의학회 1997 대한후두음성언어의학회지 Vol.8 No.2
Many tools have been used to evaluate the voice abnormalities of velopharyngeal insufficiency(VPI). The aim of study was to obtain the objective evaluation method of VPI by comparing the acoustic and nasalance data of experimentally induced VPI group and those of normal control group. Ten healthy young men were included in this study Mild and severe VPI were experimentally induced by retracting velopharyngeal movement. Using the nasometer, we obtained the nasalance score of the sustained oral vowels and those of three types of nasometer passages and the slope scores of nasogram of nasal words. And we analysed the change of formant frequencies for the sustained oral vowels and the changes of various parameters of hyper-tnasality by the computerized speech analysis system. The nasalance score of sustained /a/ was increased significantly in VPI conditions. There was no changes in the slope score of nasogram. On the acoustic speech analysis, the second formant frequencies of vowel /e/ and /i/ were decreased significantly in VPI conditions. This results suggested that the measurement of nasalance score and formant frequency might be useful in the evaluation of VPI.
윤자복,조경래,정상원,최정환,유영삼,우훈영,이강수 대한후두음성언어의학회 2001 대한후두음성언어의학회지 Vol.12 No.2
Backgrounds & Objectives : Prolonged hearing loss was considered as one of the factors which have the potential to cause vocal changes. However, the analysis of quality of phonation in hearing loss patients has not been achieved enough. The purpose of the study was to evaluate the difference in objective acoustic parameters between long-term hearing impaired patients and normal control group. Material & Methods : The material of this investigation comprised a group of 20 patients (M : F=10 : 10) with moderate or profound hearing loss(over 50dB). The duration of all hearing loss was over 1 year. All of them underwent the acoustic examinations comprising electroglottography, multidimensional voice program and formant analysis during phonation of the bowels /a/ with free confortable tone and /i/ with voluntary high tone. The results of the acoustic examinations were compared with those of a control group, composed of 20 sex- and age-matched normal hearing subjects. Results : In the male hearing loss subjects, the significant increase was detected in pitch and shimmer during phonation of /a/ and in pitch during phonation of /i/. In addition, this group was characterized by decreased fundamental frequency during phonation of /i/. In female, there was no difference between hearing loss group and normal control group except a decreased formant 1 frequency. Conclusion : Long-term moderate and profound sensorineural hearing loss could affect the objective voice parameters.
알레르기 비염 마우스 모델에서 CpG Motif Oligodeoxynucleotide 투여를 통한 알레르기 반응의 억제
윤자복,김정훈,이철희 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.5
Background and Objectives:The clasic imunotherapy has the inconvenience and the risk of anaphylaxis. Recent reports revealed that imunostimulatory DNA sequences (CpG motif, ISS-ODN) have been shown to act as strong Th1 response-inducing adjuvants and DNA based vaccination might be an effective therapeutic option for the treatment of allergic disease. In our study, we investigated whether ISS-ODN have anti-allergic efect in the mouse rhinitis model of Dermatophagoides farinae (Der f), the most common allergen in Korea. Materials and Method:C57BL/6 mice were sensitized with crude extract of Der f extract. After injection of ISS-ODN, several parameters of allergic response were evaluated. Results:In-jection with ISS-ODN supressed itching symptom, eosinophilic infiltration into nasal mucosa and the splenic T cell pr-oliferation after Der f allergen challenge in the murine model of allergic rhinitis. However, injection with ISS-ODN did not show a detectable Der f-specific IgE suppresion. Conclusion:in the allergic rhinitis model of Der f allergen. House dust mite allergy can be reduced by the injection with ISS-ODN. (Korean J Otolaryngol 2002;45:462-6)
Rhinomanometric Measurements Before and after Septoplasty
김종남,윤자복,김춘동,민양기 대한비과학회 1995 Journal of rhinology Vol.2 No.1
We evaluated the outcome of septoplasty by measuring the nasal airway resistance using anterior rhinomanometry. Nasal airway resistances were measured in 70 normal adults as reference values and preoperative and postoperative nasal resistance were measured in 27 patients who underwent septoplasty. The total resistance in control group was 0.37 Pa/cm³/sec after septoplasty. The difference between preoperative and postoperative total nasal resistance showed a good correlation with obstructive symptom.
김광현,윤자복,안순현 대한기관식도과학회 1995 大韓氣管食道科學會誌 Vol.1 No.1
From 1988 to 1995, 59 patients with laryngotracheal stenosis were operated with resection of stenotic segment and end to end anastomosis in Seoul national university. Among these patients, 36 were tracheal stenosis, 17 were combined lesion of subglottis and trachea and 5 were subglottic stenosis. The success of procedure was determined by stoma closure or decannulation and an overall 89.8% success rate was achieved following 165 procedures. The success rate showed correlation with severity of stenosis and the number of procedures done was related to the site of stenosis. There was no mortality and granulation formation, unilateral vocal cord palsy were the common complication of end to end procedures.