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흰쥐의 허혈-재관류로 손상된 간에서 Alpha-Tocopherol의 효과
유운용(Wun Young Yu),김형기(Hyung Kee Kim),권준택(Jun Tack Kwon) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: Ischemia-reperfusion injury is responsible for organ damage in a variety of pathological events such as myocardial infarction, stroke and graft failure after organ transplan- tation. Reperfusion is essential for the salvage of ischemic state. But reperfusion itself is also thought to be accompanied by its own component of injury. Reperfusion is a particularly potent stimulus for free radical formation. Free radical attack on biological membranes, such as the plasma membrane, mitochondria and endoplasmic reticulum, can lead to the oxidative destruction of the polyunsaturated fatty acids of the membranes through lipid peroxidation. In the present study, the possible protective effect of alpha-tocopherol against 15 min ischemia and subsequent 60 min reperfusion in the rat liver was investigated. Methods: Ischemia of the left and median lobes was induced by ligation of the left portal vein and the hepatic artery for 1S min. 60 min after reperfusion, experiments were initiated. Results: In ischemia-reperfusion on liver, serum AST and ALT activities and the level of malondialdehyde(MDA) in the liver homogenate were significantly increased. In addition, levels of cytochrome P-450 decreased in a microsomal fraction during ischemia-reperfusion. When rats were pretreated with alpha-tocopherol(200 mg/kg p.o, daily for 3 days), alpha-tocopherol suppressed the elevation of serum AST, ALT and MDA level and the decrease in cytochrome P-450 content. Conclusions: Free radicals play a major role in ischemia- reperfusion injury in the liver. Alpha-tocopherol exerts its beneficial effect on liver ischemia-reperfusion injury. Therefore, anti-oxidative effect of alpha-tocopherol is considered a probable suppressing mechanism on liver injury caused by ischemia-reperfusion. (Korean J Gastroenterol 1995;27:323 - 330)
윤상호,김성목,한지희,배영만,김대하,정대관,강신재,이찬주,유운용,김희연,이혜경,정승혜 대한내과학회 1994 대한내과학회지 Vol.46 No.5
The cystic lymphangioma of adrenal gland is a rare benign tumor. It has not been reported in Korea. The present study represents the first report of cystic lymphangioma of adrenal gland in Korea. It's exact etiology is obscure but thought to be related to a congenital abnormal development of lymphatic system. In addition, it is associated with the failure of communication with the central lymphatic system. The clinical significance of cystic lymphangioma is related to its size manifest itself as a palpable mass early in life. Preoperative clinical and laboratory characteristics are non-specific. Recently we experienced a case of cystic lymphangioma of the adrenal of the adrenal gland in 28-year-old female and reported it with a review of the literature.