人蔘에탄올엑기스가 鉛毒性에 미치는 影響

안영근,정종갑,김주영,김정훈,김관수 한국환경독성학회 1987 환경독성보건학회지 Vol.2 No.1

The effects of ginseng ethanol extract on the toxicity of lead acetate in mice were examined. Mice were given intraperitoneally daily doses of lead acetate 50mg/kg with ginseng ethanol extract 50mg/kg, 100mg and 200mg/kg for 3 weeks. The exposure of lead acetate showed the toxicity at all experimental assay such as the gain of body weight, the ratio of some organs weight to body weight, serum transaminase activity and creatinine value, hematocrit and WBC counts. These toxicities were inhibited significantly by the ginseng ethanol extract administration. The 50mg/kg and 100mg/kg administration of ginseng ethanol extract inhibited histopathological changes on kidney by lead acetate, whereas the 200mg/kg administration of the fraction enhanced histopathological changes.

환경오염과 면역 -환경화학물질의 면역독성- <환경보전과 약사>

안영근 대한약학회 1988 약학회지 Vol.32 No.2

Amygdalin의 經口投與毒性에 미치는 Cysteine과 Streptomycin의 影響

安榮根,吳琮,鄭址乾,金正勳 한국환경독성학회 1989 환경독성보건학회지 Vol.4 No.2

Amygdalin has been used for a long time as an anticancer agent. But because of its toxicity, it is difficult to administer continuously for treatment of cancer. This paper was attempted to reduce the side effect and toxicity of amygdalin. That is, effects of cysteine and streptomycin on the toxicity of amygdalin were investigated in rats orally administered amygdalin. 1. The group administered only amygdalin 400 mg/kg was effected on the lung and body weight, hematocrit, hemoglobin, clotting time, SGOT and albumin value. That is, lung and body weight, hematocrit hemoglobin and albumin value were significantly decreased. SGOT and clotting time were significantly increased compared with those of normal group. 2. Weight of lung was significantly increased in the C group (administred amygdalin 400 mg/kg and cysteine 300 mg/kg), D group (amygdalin 400 mg/kg and streptomycin 10 mg/kg), E group (amygdalin 400 mg/kg, streptomycin 10 mg/kg and cysteine 200 mg/kg)and F group (amygdalin 400 mg/kg, streptomycin 10 mg/kg and cysteine 300 mg/kg). 3. Values of hematocrit and hemoglobin were significantly increased, and clotting time was significantly decreased, in the E group and F group compared with those of A group. 4. SGOT was significantly decreased in the C group, E group and F group compared with that of A group. 5. The blood cyanide concentration was significantly decreased in the E group and F group compared with that fo A group. 6. In short, coadministration of cysteine and streptomycin are considered to reduce the toxicity of amygdalin in rats orally administered.

마우스에 있어서 카드뮴의 면역독성에 미치는 인삼 석유 Ether분획의 영향(II)

안영근,김정훈,이상근,황갑수 환경독성보건학회 1988 환경독성보건학회지 Vol.3 No.3

Experiment was performed to investigate the immunotoxicity of cadmium administered orally and the effect of ginseng petroleum ether fraction on it. Mice were given 3, 30, or 300 ppm cadmium as cadmium chloride orally in the drinking water and injection of ginseng petroleum ether fraction intraperitoneally for 4 weeks. Mice were sensitized and challenged u'ith sheep red blood cells (5-HBC). Immune response was evaluated by delayed type hypersensitivity (DTH), Rosette forming cell (RFC), phagocyte activity, and natural killer cell activity (NK cell activity). In the present study, cadmium suppressed the cellular immunity, It also depressed phagocyte activity very significantly in all cadmium-administered groups, NK cell activity in the cadmium-300 ppm administered group. Ginseng petroleum ether fraction showed restoring effect on the decrease in RFC by cadmium-administration. Remarkably, it showed very significant restoring effect on the depression of phagocyte activity induced by cadmium-administration. From this result, we suppose that the anti-tumor effect of ginseng ether or petroleum ether extract, which has been reported by some other researchers, is mainly due to the increase of phagocyte activity by it's administration.

Ethanol의 면역독성에 대한 인삼엑기스의 영향

안영근,김정훈,이병준 환경독성보건학회 1988 환경독성보건학회지 Vol.3 No.3

Experiments were performed on mice to investigate the effect of panax ginseng extracts on the immunotoxicity of ethanol. Immune response were evaluated by antibody production, Arthus reaction, delayed type hypersensitivity (DTH), Rosette froming cell (RFC) and macrophage activity in mice, sensitized and challenged with sheep red blood cells. The weight of liver, spleen and thymus were measured. Following results obtained in this experiment. The exposure of ethanol decreased humoral and cellular immune response, the body weight and macrophage activity. Ginseng extracts such as ethanol extract, petroleum ether extract and n-butanol fraction were significantly increased the body weight. The administration of ginseng ethanol extract and ginseng petroleum ether extract were restored or increased humoral and cellular immune response. Macrophage activity was decreased by ethanol, but restored by the ginseng extracts.

염증 표지자가 비허혈성 심부전 환자의 예후 예측에 중요한가?

안영근,정명호 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.5

The Role of Nuclear Factor Kappa B Activation in Atherosclerosis and Ischemic Cardiac Injury

안영근,김용숙,정명호 대한심장학회 2006 Korean Circulation Journal Vol.36 No.4

The NF-κB family of transcription factors plays a critical role in many tissues by modulating both inflammation and cell survival, and this primarily comes about through transcriptional regulation of the downstream effecter genes. This central role of coordinating complex programs of gene induction suggests that the NF-κB transcription factors and/or the signaling pathways leading to their activation may present a prime opportunity for performing therapeutic intervention. However, the dual role of this pathway in inflammation and survival dictates rigorous and empiric validation of such interventions in realistic models of disease before we can translate research findings to the clinical arena. Interestingly, the precise approach chosen to modulate NF-κB activation appears to dramatically alter the balance of the downstream effects on apoptosis and inflammation. Here we provide a brief overview of NF-κB signaling and its role in atherogenesis as well as in acute coronary syndromes, while considering the clinical implications for therapeutic strategies. (Korean Circulation J 2006;36:245-251)

마우스에 있어서 Cimetidine , Ranitidine 및 Famotidine이 免疫反應에 미치는 影響

안영근,김정훈,이상근 한국환경독성학회 1990 환경독성보건학회지 Vol.5 No.2

Experiments were performed on mice to investigate the influences of cimetidine, ranitidine and famotidine on the immune response. Immune response were evaluated by antibody, Arthus reaction (Arthus), delayed type hypersensitivity (DTH), rosette forming cell (RFC), phagocyte activity and whit( blood cell (WBC) in mice, sensitized and challenged with sheep red blood cells (SRB"). The weight of liver, spleen and thymus were measured. Following results obtained in this experiment. 1) The administration of cimetidine as compared to normal group significantly decreased Arthus, Hemagglutinin titer (HA), RFC, DTH, WBC and phagocyte activity, but increased the activity of serum albumin. 2) The administration of ranitidine as compared to normal group decreased RFC and HA. 3) The administration of Famotidine as compared to normal group decreased DTH and RFC, and significantly decreased HA, Arthus and serum protein. 4) The administration of ranitidine and famotidine decreased more humoral immune response than cellular immune response, but the administration of cimetidine significantly decreased humoral and cellular immune response, WBC and phagocyte activity.

영산강상류와 동복천의 상수용 하천수의 수질오탁이 염소요구량에 미치는 영향에 관한 연구

안영근,주흥규,서화중 ( Young Gun Ahn,Heung Kyu Jhoo,Hwa Joong Sheo ) 한국하천호수학회 1976 생태와 환경 Vol.9 No.3·4

This study aimed to aquire information about chlorine disinfection of general river water for city water works and rural water supplies. In this experiment chlorine demand and other selected 6 items were determined on river water sample(n=120) on April, May and June in 1976. Analyzing the determined data statisticaly the chlorine demand of river water was presumed as a reliable average by month and area. April has 0.93±0.245ppm of chlorine demand, May 1.04±0.84ppm and June 1.46±0.024ppm. Hwang Ryong river has 12±0.27ppm of chlorine demand, Ji Seok river 1.1±0.31ppm, Geuk Rak river 1.5±0.15ppm and Dong Bok Dam 1.13±0.021ppm. To know the influence of water pollution on chlorine demand the author examine the relationship between chlorine demand and the other 6 items by determining correlation coefficient. All have strong and significant correlation having γ=0.79∼.0.91 range. KMnO_4, consumed, chlorine demand has strongest relationship of these. Because turbidity is regarded as representative of pollutant in water works treatment the relationship between turbidity and other pollutant are examined. All have strong and significant correlation coefficient having γ=0.65∼0.91 interval. The relationship between turbidity and BOD is strongest of these.

영산강 중류 및 상류수계의 ABS 오염도에 관한 연구

안영근,서화중 ( Young Gun Ahn,Hwa Joong Sheo ) 한국하천호수학회 1976 생태와 환경 Vol.9 No.3·4

The contamination level of ABS, the synthetic detergent, was determined at eleven areas of upper streams and mid streams of Young San river on April, May and June in 1976. Throughout the whole experiment Ji Seok, Hwang Ryong and upper Young San river all had below 0. 075ppm ABS residue, and in these area ABS contents were similar to each other. The sudden increasing tendency of ABS contents at the mid stream are attributed to being greatly affected by much polluted Gwang Ju stream which has 0.235∼0.275ppm of ABS. But dilution of pollutant was taken place in this area by the inflowing of Ji Seok and Hwang Ryong river. On June ABS content and other pollutant increased a little as compared with April and May. But at any area it did not exceed 0. 5ppm, the standard value of drinking water. To know the influence of ABS contamination on DO content the relationship between ABS and DO was examined by calculating correlation coefficient. This relationship has strong and significant correlation(r=-0.78) and the distribution trend of frequency are more fit to the curve line equation xy-6.3x=0.045 than to the straight line equation y=-3.9x+7.4. In the relationship between ABS and COD a strong and significant correlation coefficient(r=0. 93) was calculated and the frequency distribute very closely along the straight line equation y=22.2x+1.21. From above facts the author found out that as the ABS contamination in general river water coexist closely with other pollutant it is likely to be considered as new water pollution index.