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이문호,문대혁,이기업,김기수,송영기,이명혜,안세현,박건춘 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.2
To define the clinical characteristics and the course of the autonomously functioning thyroid nodule (AFTN) in Koreans, the authors reviewed case records of the patients with AFTN from May 1989 to December 1991. Among 1412 cases of thyroid nodule, 48 (3.4%) had AFTN, with 44 females and 4 males and mean age (±S.D.) of 45.2 (±15.0) years, ranging 17 to 79 years. The age and sex distribution of the patients with AFTN were not different with those in patients with cold thyroid nodules. Of the 48 patients with AFTN, 13 had hyperthyroidism (8 clinical and 5 subclinical). Hyperthyroid patients had larger nodule than euthyroid patients, however, their age was not different. Five patients with clinical hyperthyroidism were treated surgically and they maintained euthyroid until 5 to 27 months after operation. One patient had papillary carcinoma, and another four had adenomatous goiter. Five patients with subclinical hyperthyroidism and 25 patients with euthyroid AFTN were followed for 5 to 35 months without specificreatment, however, none of them showed significant changes in thyroid function. In summary, AFTN is not frequent in Koreans, some of AFTN is maligant, surgery is an effective therapeutic modality, and AFTN runs a chronic stable course without an abrupt change in function. (J Kor Soc Endocrinol 7:121~126, 1992)