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춘계학술대회 : 포스터발표 ; HBV-만성간질환에서 basal core promoter 및 precore 변이의 축적이 간질환의 진행에서의 역할
송병철,최수길,조유경,김흥업 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
Background: Despite the pathogenic role of the basal core promoter (BCP) and the precore mutations in chronic hepatitis B virus (HBV) infection, their role in the progression of liver disease is still controversial. We analyzed whether the accumulation of
제주지역 만성 B형 간질환 환자에서 임상 양상에 따른 HBV 유전자형의 분포
송병철,김범준,정주영,염충호,이대호,김진석 제주대학교 생명과학연구소 2003 제주생명과학연구 Vol.6 No.1
Background/Aims: The genotype of HBV has been suggested to correlate with the clinical outcome of HBV infection. We analyzed the distribution of HBV genotype according to the clinical outcome of HBV infection in Jeju island. Methods: A total of 145 HBsAg-positive samples were enrolled. To identify specific patterns of HBV genotypes, we performed restriction fragment length polymorphism (RFLP). If typical restriction pattern of RFLP was not determined, phylogenetic analysis was performed. Results: RFLP analysis was possible in 65 patients. Clinical diagnoses of the 65 patients with chronic liver disease were as follows: HBeAg-positive healthy carrier (HBeAg+, anti-HBe-, HBV DNA+, transaminase normal: n=20): HBeAg seroconversion (n=12): chronic hepatitis B (n=14): liver cirrhosis (n=9): hepatocellular carcinoma (n = I0). Sixty-two patients showed typical restriction pattern by HinfI. However, 3 patients showed unique restriction pattern by HinfI, which were not reported in literature. When phylogenetic analysis was performed to classify the genotype of these 3 patients, they were also genotype C. Whereas, all patients showed typical restriction patterns by Tsp509l, which were reported in genotype C. Conclusion: All chronic HBV infection are genotype C in Jeju island regardless of clinical outcome.