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박세제(S. J. Park),박준홍(J. H. Park),이경훈(K. H. Lee),김영환(Y. H. Kim),김병민(B. M. Kim),김동환(D. H. Kim) 한국소성가공학회 2014 한국소성가공학회 학술대회 논문집 Vol.2014 No.10
Recently, the amount of spring usage is on increase in the automotive and aircraft parts industry as well as home appliances. Manufacturing of spring is a need for diversification, specialized, mass production and high precision. Therefore it is very important to know the bending method and forming technique according to the shape of spring. In this study, to find the optimal bending method for the motor spring, the FE-simulation was executed using orthogonal array. The design parameters are exposed length, width of vibrate and feed rate. Then, the optimal combination of design parameters was suggested using ANN technique.
박유환(Y .H .Park),정춘혜(C .H .Chung),조영신(Y .S .Cho),김동규(D .G .Kim),손현화(H .H .Son),서영선(Y .S .Seo),이미자(M .J .Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : The role of oncogenes and tumor suppressor genes in the pathogenesis of gastric carcinoma has recently received considerable attention. The tumor suppressor gene, p53 locus on chromosome 17p, ceases a mitosis in G1/S check point after DNA demage. Abnormality of the p53 tumor suppressor gene plays an important role in alteration of cells and possibly leads to cancer development. The authors investigated the correlation between expression of p53 and prognosis in advanced gastric carcinoma. Methods : Expression of tumor suppresor gene p53 was investigated immunohistochemically in the primary lesion of 34 patients with advanced gastric carcinoma using paraffin embedded surgical specimens and the relationship of p53 immunopositivity with the clinicopathologic variables(Age, Sex, TNM staging, Lauren classification, Borrmann classification), 5-year survivals and life curves were analyzed. Kaplan and Meier's method is used as a life curve and log crank method is used for the analysis of prognostic factor. Results : Total p53 positive rate was 53% (18 of 34) of all cases. p53 immunopositivity was not associated with other clinicopathologic variables. The 5-year survivals were 44% and 11% for patients with p53 negative and positive gastric carcinomas, respectively. Patents with the expression of p53 has predominantly poor results in comparison of life curve(p<0.05) Conclusion : These findings suggest that p53 gene alteration be associated with poor prognosis of advanced gastric adenocarcinoma(Korean J Med 58:568-574, 2000)