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- 저자 : 박진경(Jin-Kyong Park) (검색결과 4 건)
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Estrogen Receptor 1 유전자 내 2개의 단일염기 다형성과 한국인 여성 정신분열병 환자의 연합에 관한 연구
박진경,이서경,이상민,박준헌,김지영,조아랑,Park, Jin Kyung,Lee, Seo Kyong,Lee, Sang Min,Park, Jun Heon,Kim, Ji Yeong,Cho, Ah Rang 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4
Objectives : Schizophrenia is equally distributed in both sexes. However, later-onset, milder psychopathology, and better outcome are associated with the females. This reason is thought to be partly due to the estrogen system. Recently, it was suggested that estrogen receptor 1(ESR1) gene polymorphisms might affect the expression of ESR1 and were associated with several psychiatric disorders. Thus, we investigated the association between two single nucleotide polymorphisms(SNPs) in the ESR1 gene and Korean schizophrenic patients in this study. Methods : Genotype, allele, and haplotype frequencies of the two SNPs(rs 2234693 and rs 2228480) were analyzed between 218 Korean controls and 158 Korean schizophrenic patients. Also, age of onset and negative symptom scale scores according to genotypes were analyzed in the patients with schizophrenia. Results : There was a significant difference in allele frequencies of rs 2234693 between the schizophrenic patients and the controls(p=0.03). Genotype distributions(p=0.03) and allele frequencies(p=0.01) of rs 2234693 were significantly different between the female schizophrenic patients and the female controls. The frequency of TC-CC genotypes compared with TT genotype in the female schizophrenic patients was significantly higher than that in the female controls(OR=2.36). The mean age of onset in the schizophrenic patients with TC-CC genotypes was significantly lower than that in the patients with TT genotype. The frequency of rs 2234693C- rs 2228480G haplotype in the female schizophrenic patients was relatively higher than that in the female controls. Conclusions : These results of our study support the possibility that the ESR1 gene polymorphisms might be involved in the susceptibility of females to schizophrenia and play a role in sex difference of schizophrenia.
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박진경 ( Jin Kyung Park ),김지연 ( Ji Yeon Kim ),변미경 ( Mi Kyong Byun ),정은혜 ( Eun Hye Jeong ) 한국주관성연구학회 2021 주관성연구 Vol.- No.56
본 연구는 Q방법론을 적용하여 중환자실 간호사의 환자중심간호에 대한 인식 유형과 각 유형별 특성을 파악함으로써, 추후 중환자실 간호사 교육 및 간호 질 향상에 기여하고자 시도되었다. 심층면접을 통해 도출된 34개의 Q 표본을 구성하고, 편의추출된 총 32명의 중환자실 간호사를 대상으로 Q 분류를 실시하였다. PQ-method 프로그램을 활용하여 주성분 분석방법(PCA)와 배리맥스회전과정을 거친 분석을 통해 가장 설명력이 높은 3개의 요인이 최종적으로 도출되었다. 분석 결과, 유형 1 ‘포괄적 이해 기반 환자공감 추구형’, 유형 2 ‘간호사 역량 기반 환자회복 지향형’, 유형 3 ‘개별화된 간호 기반 환자행복 추구형’으로 각각 명명되었다. 본 연구결과를 바탕으로 중환자실 간호사의 환자중심간호 맞춤형 교육프로그램 개발이 필요하다. 또한 교육프로그램의 효과에 대해 간호사와 환자측면에서 검증함으로서 지속적인 연구가 이루어져야 할 것이다. This study was attempted to contribute to improving the quality of nursing care and education of nurses in the intensive care unit by applying the Q-methodology to identify the types of perceptions and characteristics of patient-centered nursing of intensive care unit nurses. In this study, 34 Q samples derived from in-depth interviews were constructed and Q sorting was performed on a total of 32 ICU nurses. The three factors with the highest explanatory power were finally derived through principal components factor analysis (PCA) and varimax rotation analysis using the PQ-method program. As a result of the analysis, Type 1 was named ‘Comprehensive understanding-based patient empathy pursuit’, Type 2 ‘Patient recovery-oriented based on nurses’ competency’, and Type 3 ‘Individualized nursing-based patient happiness pursuit’, respectively. Based on the results of this study, it is necessary to develop customized education program for patient centered-nursing for intensive care unit nurses. In addition, further study should be conducted to verify the effectiveness of the education program from the perspectives of nurses and patients.
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이준(Jun Lee),장준석(Jun-Seok Jang),임용택(Yong-Taek Lim),엄진기(Jin-Gi Eom),박진경(Jin-Kyong Park) 한국철도학회 2010 한국철도학회 학술발표대회논문집 Vol.2010 No.7
Recently the role of a railroad is emphasized as the imprortant part for growth for the low carbon green growth and the social consensus about the railroad investment is actively progressed. The various social economic value in which the travel demand change over of the environment-friendly railroad system can bring becomes with public debate as much as a discussion is not any more necessary. In this research, the influence that it recognized that the travel time improvement by the high speed rail was the most important element among many method that it can increase the railroad use efficiency in which it connects the interregional major cities and the railway travel time improvement reaches to the rate of railway and road travel time, and the environment like the carbon emission quantity was comprehensively inquired.
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