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마우스 대식세포에서 도기탕 (導氣湯) 메탄올 추출물의 항산화 및 항염증 효과
박선동 ( Sun Dong Park ),김동완 ( Dong Wan Kim ),윤현정 ( Hyun Jeong Yun ),허준영 ( Jun Young Heo ),김태훈 ( Tae Hoon Kim ),조현진 ( Hyun Jin Cho ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.4
Objective: The aim of this study was to determine whether methanol extract of Do-Ki-Tang (DKT) inhibit free radical generation and production of nitrite an index of NO, PGE2, iNOS, COX-2 and pro-inflammatory cytokines such as TNF-a, IL-1b, IL-6 and MCP-1 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods: Cytotoxic activity of extract on RAW 264.7 cells was measured using 5-(3-caroboxymeth -oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. The expression level of inflammatory response-related proteins was confirmed by western blot. The production of proinflammatory cytokines was measured by ELISA. Results: Our results indicated that DKT scavenged DPPH radical and nitric oxide in vitro. Moreover, DKT significantly inhibited the LPS-induced NO, PGE2 production and iNOS, COX-2 expression accompanied by an attenuation of TNF-a, IL-1b, IL-6 and MCP-1 formation in macrophages. Furthermore, DKT treatment also blocked LPS-induced intracellular ROS production and the activation of NF-kB and MAPKs. Conclusion: Our data suggest that the anti-inflammatory effect of DKT is mediated through down-modulation of pro-inflammatory mediators and cytokines by blocking the signaling pathways of NF-kB and MAPKs. These inhibitory effects by DKT represent a potential therapeutic approach to the treatment of inflammatory diseases.
GGEx18의 ethyl acetate 분획물에 의한 고지방식이 비만 마우스의 식이효율과 혈중 leptin 농도에 미치는 영향
박기정,이희영,이혜림,윤미정,박선동,이용태,심지빈,최홍화,신순식,Park, Ki-Jeong,Lee, Hee-Young,Lee, Hye-Rim,Yoon, Mi-Chung,Park, Sun-Dong,Lee, Yong-Tae,Shen, Zhi-Bin,Cui, Hong-Hua,Shin, Soon-Shik 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.1
Objectives : This study was designed to determine the effects of the GGEx18 ethyl acetate fraction(EF) on body weight gain, feeding efficiency ratio, and obesity-related factors in plasma as well as histology of liver and adipose tissues using high fat diet-fed male C57BL/6N obese mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, EF(1), EF(2) and EF(3). After mice were treated with EF for 9 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also analysed histology of liver and adipose tissues on high fat diet-fed male C57BL/6N obese mice. Results : Compared with control, EF-treated mice had significantly lower body weight gain and feeding efficiency ratio. Consistent with the effects on body weight gain, EF significantly decreased the adipose tissue weight compared with control. Consistent with the effects on feeding efficiency ratio, EF significantly decreased plasma leptin concentrations compared with control. EF reduced the size of adipocytes as well as hepatic lipid accumulation compared with control. EF seems to be safe since not only the plasma levels of ALT and AST are within the normal range, but also EF did not show any toxic effects on organs. EF(3) was most effective among EF(1), EF(2), and EF(3) at doses of 25, 50, and 100 mg/kg, respectively. Conclusions : These results demonstrate that EF effectively reduces body weight gain, feeding efficiency ratio in high fat diet-fed obese mice, leading to the modulation of obesity. In addition, EF decreases the size of adipocytes and improves plasma lipids and controls hepatic lipid accumulation, suggesting that EF may act as a therapeutic agent for obesity.
박선동(Park, Seon Dong),서상일(Seo, Sang Il),윤동진(Yoon, Dong Jin) 한국측량학회 2009 한국측량학회 학술대회자료집 Vol.2009 No.4
항공사진촬영은 계획된 노선을 따라 항공기를 조정하여 적절한 위치에서 촬영을 수행하는 작업이다. 특히 3차원 공간데이터 구축을 위하여 사용되는 다각사진촬영시스템의 경우 대형 CCD가 중형 CCD를 사용함으로써 촬영면적이 크지 않아서 적절한 위치에서 촬영이 이루어지지 않는 경우 충분한 중복도를 확보하지 못하여 외부표정요소 결정에 문제가 발생할 소지가 있다. 따라서, GPS/INS를 이용하여 정확한 항공기의 위치를 결정하여 사전에 계획된 위치에서 촬영을 실시함으로써, 정확한 3차원 공간데이터의 모델링을 수행할 수 있다. The Aerial photographic mission is working of taking picture at appropriate point at operating aircraft. Specially, because multi-looking camera system for 3D spatial data construction don"t use large size CCD camera, do use middle size or small size CCD camera, Exterior parameter can"t be calculated because of not enough overlap, if taking picture at inappropriate position. Therefore, we can construct 3D spatial modeling data by taking picture at planned points using GPS Positioning information.
마우스대식세포주인 RAW 264.7에서 金鈴子散(金鈴子散)의 항염증 활성 연구
박선동 ( Sun Dong Park ),김도형 ( Do Hyung Kim ),이효승 ( Hyo Seung Yi ),윤현정 ( Hyun Jeong Yun ),차창민 ( Chang Min Cha ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.2
Objective: The aim of this study was to determine whether methanol extract of Keum-Ryung-Ja-San (KRJS) inhibit production of NO, PGE2, iNOS, COX-2 and pro-inflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Methods: Cytotoxic activity of extracts on RAW 264.7 cells was measured using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. The nitric oxide (NO) production was measured by Griess reagent system. And proinflammatory cytokines and PGE2 were measured by ELISA kit. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Ik-B-a and nuclear NF-k B p65 expression were detected by western blot. Results: Our results indicated that methanol extract of KRJS significantly inhibited the LPS-induced NO, PGE2 production and iNOS, COX-2 expression accompanied by an attenuation of TNF-a, IL-1b and IL-6 production in RAW 264.7 cells. Moreover, methanol extract of KRJS treatment also blocked LPS-induced NF-k B activation. Conclusion: These findings indicate that methanol extract of KRJS inhibits the production of pro-inflammatory mediators and cytokines via suppression of NF-k B activation. Take together, these results indicate that methanol extract of KRJS has the potential for use as an agent of anti-chronic inflammatory diseases.
박선동 ( Sun Dong Park ),조현진 ( Hyun Jin Cho ),윤현정 ( Hyun Jeong Yun ),이효승 ( Hyo Seung Yi ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.2
Objectives: This study was designed to investigate the effects of anti-oxidation of fractionated Pulsatilla koreana NAKAI (PK) extracts. And we examined to determine that a certain fractionated extract has the best anti-oxidative effects between the fractionated PK extracts. Methods: Anti-oxidative effects of fractionated PK extracts was measured by scavenging activities of DPPH, superoxide, nitric oxide (NO) and peroxynitrite radicals. And also scavenging activities of anti-oxidation in lipopolysaccharide (LPS)-treated RAW 264.7 cell was measured. After these examination, we determined a fraction that has best anti-oxidative effects. Results: Fractionated PK extracts inhibited radicals effectively. Also in RAW 264.7 cell, intracellular oxidation has inhibited by PK extracts. In these tests, ethyl acetate (EA) fraction has the best anti-oxidative effects among PK extracts. Conclusions: This results demonstrate that PK extracts exhibit anti-oxidative effects. And EA fraction has the best inhibition effects among the six fractions of PK.
마우스대식세포주인 RAW 264.7에서 SD-01의 항염증 활성 연구
박선동 ( Sun Dong Park ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.3
Objective: The aim of this study was to investigate anti-inflammatory activity of SD-01 methanol extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods: Cytotoxic activity of SD-01 methanol extract on RAW 264.7 cells was measured using 5-(3-caroboxymeth-oxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. The nitric oxide (NO) production was measured by Griess reagent system. And proinflammatory cytokines and PGE2 were measured by ELISA method. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), I k-B-alpha and nuclear NF-k B p65 expression were detected by western blot. Results: Our results indicated that methanol extract of SD-01 significantly inhibited the LPS-induced NO, PGE2 production and iNOS, COX-2 expression accompanied by an attenuation of TNF-a, IL-1b, IL-6 and MCP-1 production in RAW 264.7 cells. Moreover, methanol extract of SD-01 treatment also blocked LPS-induced NF-k B activation. Conclusion: These findings indicate that methanol extract of SD-01 inhibits the production of pro-inflammatory mediators and cytokines via suppression of NF-k B activation. Take together, these results indicate that methanol extract of SD-01 has the potential for use as an agent of anti-chronic inflammatory diseases.
deegree를 이용한 국토공간영상정보 국가 표준파일포맷(NIX)의 OGC 표준 프로토콜 지원 방안 연구
박선동(SeonDong Park) 대한공간정보학회 2009 한국지형공간정보학회 학술대회 Vol.2009 No.9
본 논문은 현재 국토지리정보원에서 국토공간영상정보 국가표준파일포맷(NIX)를 사용하여 기존에 촬영된 항공사진을 DB화하여 보관하고 있으며 인터넷을 통하여 항공영상의 확인 및 교부 서비스를 수행하고 있다. 그러나 이러한 서비스는 OGC등에서 권장하고 있는 웹 매핑 표준을 지원하지 않고 있음으로 인해, 기타 웹서비스와의 연계등의 매우 불리하다. 또한 NIX의 경우 새로운 영상 포맷을 정의한 것으로 기존의 웹서비스에서 직접적으로 사용하는 것은 거의 불가능하다. 따라서 OGC에서 정의한 웹 표준을 지원함으로써 다른 웹 서비스와의 연계를 수행할 수 있는 방안을 강구하고 Open Source 웹 맵 서버를 사용하여 데이저 제공자 부분에 NIX를 지원할 수 있도록 개발함으로써 NIX 포맷을 일반적인 영상포맷으로 변환하지 않고 서비스 수행이 가능하다.