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위암에서 TGF - 1 과 TGF - 2 형 수용체의 역할
박동일(Dong Il Park),손희정(Hee Jung Son),송상용(Sang Yong Song),최원혁(Won Hyeok Choe),임윤정(Yun Jeong Lim),박상종(Sang Jong Park),김재준(Jae J . Kim),김영호(Young Ho Kim),이풍렬(Poong Lyul Rhee),백승운(Seung Woon Paik),이종철(Jong 대한내과학회 2001 대한내과학회지 Vol.61 No.4
N/A Background: Transforming growth factor-beta (TGF-β) is a potent inhibit or of epithelial cell growth. However, carcinoma cells, unlike normal cells, can escape from negative regulation by TGF-β through lack of expression or mutation of TGF-β receptor gene. In this study, we investigated the role of TGF-β1 and TGF-β type 2 receptors (TβR-2) in the progression of gastric cancer. Methods: We analyzed TGF-β1 and TβR-2 mRNA expression semi-quantitatively, measured by comparative RT-PCR using GAPDH, in 23 patients who underwent gastric resection for gastric cancer. We analyzed the relationship between the clinicopathologic findings and the level of the TGF-β1 and TβR-2 mRNA expression in carcinoma tissues and in adjacent normal tissues of gastric cancer. Results: (1) TGF-β1 and TβR- 2 mRNA were expressed in all of the carcinoma tissues and adjacent normal tissues without statistical difference in the level of the expression. (2) The level of TGF-β1 mRNA expression was higher in patients with early gastric cancer , negative lymph nodes or negative perineural invasion. There was no significant correlation between the level of TGF-β1 mRNA expression and several parameters such as age, gender, tumor size, differentiation, Lauren's classification, and vascular invasion. (3) There was no significant correlation between the level of TβR-2 mRNA expression and several prognostic variables described above. (4) There was significant correlation between the level of TGF-β1 and TβR-2 mRNA in carcinoma tissues. Conclusion: The above data indicates that TGF-β1 may contribute in the early stages of gastric carcinogenesis. Further studies are required to clarify the role of TGF-β1 in gastric carcinogenesis. (Korean J Med 61:409-416, 2001)
라미부딘과 HBIg 1주일 단기 병합요법은 간이식 후 B형 간염 재발 방지에 HBIg 장기 고용량 투여요법만큼 효과적인가?
김성주,장재권,이석구,도재혁,백승운,최문석,조재원,고광철,이풍렬,이종철,최규완,박상종,이준혁,김재준,임윤정,안병훈 대한소화기학회 2001 대한소화기학회지 Vol.37 No.1
Background/Aims : The aim of this study was to evaluate whether the regimen consisted of lamivudine and one-week HBIg for HBV prophylaxis after liver transplantation is as effective as long-term therapy of high dose HBIg. Methods: Sixty-one patients with HBV infection were randomly divided into two groups: HBIg group of 31 patients and combination group of 30 patients. In the HBIg group, HBIg was given according to the standard dosing schedule. In the combination group, lamivudine was given indefinitely from at least 4 weeks before transplantation, and 10,000 IU of HBIg was given during anhepatic phase and 6 consecutive days. Results: The two groups were not different in HBeAg and HBV DNA positivity. In the HBIg group, the median follow-up of 20 long-term survivors was 12.7 months (range: 4.0 - 48.2) and that of 23 survivors in the combination group was 22.3 months (4.2 - 42.2). Hepatitis B recurred in a patient of the HBIg group and 2 of the combination group. The recurrence-free survival rate of long-term survivors was 66.7% (95% C.I., 39.5% - 93.9%) in the HBIg group and 76.0% (58.6% - 93.4%) in the combination group after 40 months. Conclusions: The combined therapy of lamivudine and one-week HBIg has an effect equivalent to long-term therapy of high dose HBIg in HBV prophylaxis after liver transplantation at a much lower cost.
혈액투석 중인 만성 신부전 환자에서 TT Virus의 감염률과 임상적 의의
이용욱,허우성,도재혁,백승운,최문석,김소정,이준행,고광철,이풍렬,이종철,최규완,박상종,이준혁,김재준,오하영,임윤정 대한소화기학회 2001 대한소화기학회지 Vol.37 No.1
Background/Aims: TT virus (TTV) is a unenveloped, single-stranded and circular DNA virus isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology. We evaluated the prevalence, risk factors, and clinical significance of TTV in patients with chronic renal failure(CCRF) undergoing maintenance hemodialysis (HD). Methods: We examined TTV DNA in serum of HD-undergoing patients and healthy controls using the nested polymerase chain reaction. Results: TTV DNA was detected in 15 (20.0%) of 75 HD-undergoing patients and 10 (13.2%) of 76 healthy controls (p$gt;0.05). The prevalence of TTV did not differ according to the duration of HD or transfusion history of the patients. The prevalence of TTV was higher in IgG anti-HBc positive patients than IgG anti-HBc negative patients (27.5% vs. 4.2%, p=0.03). There was no relationship between TTV infection and liver diseases. Conclusions: The prevalence of TTV infection in CRF patients undergoing HD was similar with that of healthy controls. These results suggest that TTV infection may share the route of transmission with HBV infection in adults.