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백굴채약침액(白屈菜藥針液)이 LPS로 유도(誘導)된 RAW 264.7 대식세포(大食細胞)에서의 항염증효과(抗炎症效果)
박동천 ( Dong Cheon Park ),박지현 ( Ji Hyeon Park ),이우경 ( U Kyung Lee ),이진규 ( Jin Kyu Leek ),서일복 ( Il Bok Seo ),김호현 ( Ho Hyun Kim ),김정선 ( Jeong Seon Kim ),김이화 ( Ee Hwa Kim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.2
Objectives: Recently, Herbal-acupuncture therapeutics has been used for the treatment of inflammatory diseases such as rheumatoid arthritis. Especially, we have been interested in chemical mediators concerned with inflammation such as prostaglandin, cytokine, nitrous oxide. The purpose of this study is investigated that the effect of Chelidonii Herbal-acupuncture solution in lipopolysaccharide-stimulated RAW 264.7 macrophages, performed several expeimental items: those are prostaglandin E2, nitric oxide and cyclooxygenase-2. Methods: The cytotoxicity of Chelidonii Herbal-acupuncture solution in RAW 264.7 macrophages were measured by MTT-based cytotoxicity assay. In order to observe cyclooxygenase-2 mRNA expression in lipopolysaccharide-stimulated RAW 264.7 macrophages, RT-PCR was used. Prostaglandin E2 formation and nitric oxide production was measured by competitive enzyme immunoassay and Griess assay. Results: 1. The MTT assay demonstrated that cytotoxic effect of Chelidonii Herbal-acupuncture solution in RAW 264.7 macrophages were not appeared before concentration of 1㎎/㎖. 2. Chelidonii Herbal-acupuncture solution inhibited cyclooxygenase-2 mRNA expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. 3. Chelidonii Herbal-acupuncture solution inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. 4. Chelidonii Herbal-acupuncture solution inhibited prostaglandin E2 formation in lipopolysaccharide-stimulated RAW 264.7 macrophages. Conclusions: On the basis of these results, It was shown that Chelidonii Herbal-acupuncture solution is significantly able to inhibit the production of PGE2 and NO, as well as COX-2 mRNA expression. Our results may provide new mechanism by which Chelidonii Herbal-acupuncture solution accounts for its beneficial effect on accelerating wound healing and anti-inflammation.
한국 남자 청소년의 VO<sub>2</sub>max 추정을 위한 새로운 20-m PST 프로토콜과 추정식의 타당도 및 신뢰도
박동호 ( Dong-ho Park ),이상현 ( Sang-hyun Lee ),김도윤 ( Do-youn Kim ),천정우 ( Jeon-woo Cheon ),김창선 ( Chang-sun Kim ) 한국운동생리학회(구 한국운동과학회) 2017 운동과학 Vol.26 No.1
PURPOSE: To develop and validate regression models to estimate maximal oxygen uptake (VO<sub>2</sub>max) from the new 20-m Progressive Shuttle Test (20-m PST) in Korean male youths aged 13-18 years. METHODS: The new 20-m PST and VO<sub>2</sub>max were assessed in a sample of 80 participants. Participants underwent a treadmill test (TT) in the laboratory and the new 20-m PST protocol (starting at 5.0 km/h and increasing by 0.75 km/h every 1 min) in a gymnasium. Participants in the validation study performed the TT with the stationary metabolic cart and the 20-m PST with a portable metabolic cart once, as well as the 20-m PST without the portable metabolic cart twice for test-retest reliability. All tests were conducted at least three days apart and in a random order. RESULTS: Mean measured VO<sub>2</sub>max (55.4±6.7 mL/kg/min) from the potable metabolic cart was significantly increased from that measured during the GXT from stationary metabolic cart (52.6±7.0 mL/kg/min, p=.001) using the new 20-m PST protocol. But it was a narrow range (2.8 mL/kg/min). The measured VO<sub>2</sub>max from the potable and stationary metabolic cart correlated at r=.89 (p<.001). Test-retest of the 20-m PST yielded comparable results (Laps r=.94 & final speed r=.89). New regression equations were developed from present data to predict VO<sub>2</sub>max for male youths: y=.875×BMI+2.031×DT (min.sec)+51.856 (r=.60, SEE=5.54 mL/kg/min). CONCLUSIONS: It is concluded that (a) the new 20-m PST protocol is a valid and reliable test and (b) this equation developed in this study provides valid estimates of VO<sub>2</sub>max of Korean male youths aged 13-18 years.
박동천(Park Dong-Cheon),송훈(Song Hun),김정진(Kim Jeong-Jin) 대한건축학회 2007 大韓建築學會論文集 : 構造系 Vol.23 No.10
This study is about thermal conductivity of polymer modified cement mortars (PCM) used as the patch repair method materials. The thermal conductivity is one of major input data in the analytic study such as FEM. The quick thermal conductivity meter based on the unsteady hot wire method was used. To consider the interacted factors influencing thermal conductivity of PCM, five testing variables such as age, types of polymers, polymer fraction, fine aggregate fraction, and moisture content condition of specimen were adopted in this test. Multiple regression equation was estimated from the test results.
온도와 습도의 변화에 따른 콘크리트 내부의 열, 수분 분포 예측
박동천 ( Park Dong-cheon ),이준해 ( Lee Jun-hae ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1
Concrete changes its internal moisture distribution depending on the external environment, and changes in the condition of the material's interior over time affect the performance of the concrete. These effects are closely related to the long-term behavior and durability of concrete, and the degree of deterioration varies from climate to climate in each region. In this study, we use actual climate data from each region with distinct climates. A multi-physical analysis based on the method was conducted to predict the difference and degree of deterioration rate by climate.
박동천 ( Park Dong-cheon ),이준해 ( Lee Jun-hae ),김용로 ( Kim Yong-ro ),송영찬 ( Song Yong-chan ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2
Lack of fine aggregate is adversely affecting the quality of concrete. Due to lack of land sand, EZZ sea sand has been used. However, the use of sea sand is also difficult because of the opposition of fishermen. The purpose of this study was to analysis the effect of slag fine aggregate to durability and compressive strength of concrete. The concrete compressive strength and durability were assessed to derive a proper mix ratio of fine aggregate.
실내 이산화탄소 농도 측정 및 편차에 따른 콘크리트 탄산화 깊이 예측에 관한 해석적 연구
박동천(Park Dong-Cheon),송훈(Song Hun),이동운(Lee Dong-Un) 대한건축학회 2012 大韓建築學會論文集 : 構造系 Vol.28 No.4
Carbon dioxide in atmosphere causes concrete carbonation which is the phenomenon, that is, the pH of concrete goes down from 12-13 to 8.85-10. Even though the carbon dioxide concentration of indoor is higher than that of outdoor, the micro measurement has not carried out. The concentration test was conducted three times in two rooms in a residential area, reading room in library, and lecture room. With all the deviation for each unit, the measured average value was 463.1~1425.3(ppm) which is more than three times than that of outdoor at the most. Without surface finishings in FEM calculation, the depth of carbonation is up to 4(㎝). At the same time, the FEM calculation considering surface finishings. Any carbonation did not appeared because of the assumption, that is, surface finishings did not deteriorate.
이산화탄소 증가의 환경영향을 고려한 콘크리트 중성화에 관한 연구
박동천(Park Dong-Cheon),송화철(Song Hwa-Cheol) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.9
To estimate the compatibility of concrete cover criterion, the change of carbonation depth was calculated by FEM model considering the effect of carbon dioxide increase of the earth which is from SRES(Special Report on Emission Scenario) published by ICCP. The period of carbonation calculation is from 2000 to 2100. The difference of carbonation depth between A1F1 scenario which is the severest among the SRES scenario and constant carbon dioxide concentration(369ppm) for 100 years is 0.0042m. The smaller difference than the result we expected is attributed to concrete pore decrement and the diffusion of calcium hydrate which is cement hydration product. The difference by water cement ratio is also small because of the increment of calcium hydrate according to the change of the amount of unit cement.
건축 외장용 도막의 콘크리트 탄산화 억제효과에 관한 연구
박동천(Park Dong-Cheon),도근영(Doe Geun-Young),박기봉(Park Ki-Bong) 대한건축학회 2008 大韓建築學會論文集 : 構造系 Vol.24 No.10
Diffusion-Reaction Carbonation Model on the base of FEM was developed to predict the carbonation depth of the paint coated concrete structure. The diffusion and solubility coefficient of the coated film used in this study were estimated by the differential pressure-CO₂ permeability device. The Diffusion-Reaction Carbonation Model constructed in this study was validated by the accelerated carbonation test using concrete specimens applied with organic coats. The CO₂ diffusion coefficient of acrylate was the highest, followed by epoxy, polyurethane, polyvinyl chloride in this study. Effects of the degradation and the number of coatings have also been analytically examined.
환경변화에 따른 콘크리트 내부의 열ㆍ수분 경년변화 예측에 관한 해석적 연구
박동천(Park Dong-Cheon),김정진(Kim Jeong-Jin),오상균(Oh Sang-Gyun),김효열(Kim Hyo-Youl),강병희(Kang Byeung-Hee) 대한건축학회 2007 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.27 No.1
The deteriorations of concrete structures such as carbonation, chloride attack, alkali-aggregate reaction, freezing damage usually depend on the moisture state in concrete. The diffusion coefficient and reaction rate of the deteriorative factors are changed by the moisture content and temperature. To evaluate the temperature and moisture content which are essential to expect the concrete deterioration qualitatively, heat-moisture coupled model was constructed by FEM. The model was verified by the existing experimental results.