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위궤양의 발생기전에 대한 시험적 및 임상적연구 - Prednisolone 투여 백서의 위 Pepsin 의 성상에 관한 연구 -
박경남,기춘석,장호연,고재경 ( Kyung Nam Park,Choon Suhk Kee,Ho Yun Chang,Jai Kyung Koh ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1
Because of its potent proteolytic nature, pepsin has been known to play an important role 'in ulcerogenesis of the stomach '>. The rate of pepsin secretion by stomach was reported to be stimulated by histamine'>, gastrin', pentagastrin >, caerulein >, secretin >, cholecystokinin> and glucocorticoids >, and inhibited by vagotomy>, histamin antag- .onists> and prostaglandins . It has been suggested that compounds which can timulate pepsin output may cause gastric ulcer and that drugs which exhibit antipeptic activity could be used as therapeutic agents for gastric ulcer. The introduction of glucocorticoids into medical practice with concomitant increase in the incidence of gastric ulcer made it clear that the adrenal glucocorticoids had a good deal to do with pepsin output and its activity-. However, no definite evidence for that tle pepsin secretion and its activity are affected by acute or chronic administration of glucocorticoids has been obtained in both experimental and clinical studies. In order to investigate the effect of glucocorticoids on pepsin activity in gastric juice, changes in the activity of pepsin vere observed in both basal a.nd gastopsin stimulated gastric juice collected from rats treated with prednisolone for fifteen days. Also studied were properties of pepsin in gastric juice to screen the compounds which specifically activate or inhibit the enzyme through the in vitro experiment .
Doxycycline 이 원인으로 사료되는 약제성 식도궤양 1예
박경남(Kyung Nam Park),이민호(Min Ho Lee),김순길(Soon Gill Kim),민영일(Young Il Min),박태현(Tae Hyun Park) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2
N/A Tetracycline induced esophageal ulcer was first described by Bokey and Hugh(1) in 1975. Thirty more cases associated with doxycycline or tetracycline ingestion have been reported since then(1-9,13). One case of drug-induced esophageal ulcer, probably due to doxycycline, is reported and compared with 18 other cases from the literature. In most cases, the patients had taken their capsules just before going to bed with little fluid intake. Some hours later they developed retrosternal burning sensation and odynophagia. Endoscopy revealed sharply demarcated ulcers with grayish white exudate surrounded by mucosal edema. Esophagogram was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of capsules and direct irritation of esophageal mucosa by drug is thought to be the cause of the esophageal ulcer. The patients on doxycycline treatment should therefore be instructed to take their capsules with copious water and not just before going to bed.
원발성간임의 (原發性肝癌) 초음파상에 (超音波像) 관한 연구
박경남(Kyung Nam Park),이창홍(Chang Hong Lee),기춘석(Choon Suk Kee),최웅환(Oung Whan Choi),이동후(Dontg Hoo Lee),이호채(Ho Chae Lee),김순길(Soon Gill Kim),민영일(Young Il Min) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.1
N/A The gray- cale ultrasonographic app arances of histopathologically proven primary hepatoma in 61 patients were evaluated retrospectively. Our study has revealed four different ultrsonographic patterns of primary hepatoma: echogenic(39.4%), sonolucent(8.2%), mixed(31.0%) and diffuse parenchymal distortion(21.3%). Of 61 primary hepatoma examined, 19 cases exhibited encapsulation. Predominantly, the marginal Contour of mass was irregular rather than smooth. Most of cases represented downward convexity of the lower edge of the liver. Both of hump and marginal irregularity on the hepatic surface were exhibited in 54.1% and 59.0% respectively. Ultrasonography makes it possible to demonstrate not only the extrinsic compression of the vascularity by the tumor mass on intrahepatic vessels, inferior vena cava, and abdominal aorta, but also extrahepatic biliary obstruction. While 40.9% of cases were found to have a cites, splenomegaly was noticed in 31.1% In fact, ultrasonography is a useful screening method for imaging primry hepatorna with pecial regard of its noninva siveness and easy application to assess the nature and extent of the lesions.
위 (胃) 십이지장궤양환자에서 (十二指腸潰瘍患者) Madecassol ( centella asiatica ) 의 사용경험
박경남(Kyung Nam Park),신현성(Hyun Sung Shin),최일균(Il Gyun Choi),이민호(Min Ho Lee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1
N/A In order to elucidate the effect of titrated extract of Centella Asiatica(TECA) on peptic ulcer, the drug was given to a total of 40 patients with peptic ulcer including 25 cases of gastric ulcer and 15 cases of duodenal ulcer. The results obtained were as follows: Of 15 patients with peptic ulcer including 9 cases of gastric ulcer and 6 cases of duodenal ulcer who received TECA alone, 14 cases(93%) exhibited a definite improvement in subjective symptoms and 11 cases(73%) showed healing of the ulcer under endoscopic and radiological observations. 2) Of 14 patients of peptic ulcer who received TECA along with antacid, 13 cases showed an improvement in subjective symptoms and 11 cases(78%) exhibited healing of the ulcer. 3) Of 11 patients with peptic ulcer who served as control, 5 cases exhibited an improvement in subjective symptoms, but there were no sign of healing in observation. 4) Activities of serum transaminases, content of blood urea nitrogen and concentrations of serum electrolytes in patients ivith peptic ulcer were determined before and after administration of the drugs and were observed to be unchanged.
갑상선 절제술 후 출혈의 발생 빈도와 주술기 기간의 혈압 및 맥박수 증가: 후향적 환자 사례군 연구
박경남(Kyung Nam Park),최서문(Seo Mun Choi),정해정(Hae Jeong Jeong) 조선대학교 의학연구원 2022 The Medical Journal of Chosun University Vol.47 No.1
Background: The frequency of post-thyroidectomy hemorrhage is low, 0.43% to 2.83%, but when it occurs, life-threatening problems such as airway compression can arise. Therefore, risk factors associated with postoperative hemorrhage should be well understood. Male, old age, hypertension, anticoagulation history, neck dissection, and bilateral thyroidectomy are the known risk factors and most bleeding occurs within the first day of the surgery. Methods: This retrospective study analyzes not only the bleeding frequency after thyroidectomy performed between 2016 and 2021, but also hypertensive and tachycardia events during the perioperative period. Results: There were 20 cases of postoperative hemorrhage over 6 years, and the incidence rate was 0.68%. Most postoperative hemorrhage was detected within 12 hours after surgery (≥75%). The incidence rate of postoperative hemorrhage was the same in both sexes, 4 patients underwent thyroidectomy, and 16 patients underwent thyroidectomy with neck dissection. Only 8 patients were previously diagnosed with hypertension, and 2 patients were taking anticoagulants. All patients with postoperative hemorrhage had hypertensive event I during the perioperative period, and 95% of patients had tachycardia event I. Conclusion: It is necessary to recognize the possibility of bleeding after surgery and to actively control hypertension and tachycardia, rather than understanding the findings of increased blood pressure and heart rate occurring during the perioperative period as temporary phenomena and proceeding without additional treatment. In addition, within 12 hours after surgery, when postoperative hemorrhage occurs the most, these patients should be classified into a risk group and closely monitored.