Doxycycline 이 원인으로 사료되는 약제성 식도궤양 1예 = A Case of Drug - induced Esophageal Ulcer , Probable due to DoxycyclineDoxycycline 이 원인으로 사료되는 약제성 식도궤양 1예

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Tetracycline induced esophageal ulcer was first described by Bokey and Hugh(1) in 1975. Thirty more cases associated with doxycycline or tetracycline ingestion have been reported since then(1-9,13). One case of drug-induced esophageal ulcer, probably due to doxycycline, is reported and compared with 18 other cases from the literature. In most cases, the patients had taken their capsules just before going to bed with little fluid intake. Some hours later they developed retrosternal burning sensation and odynophagia. Endoscopy revealed sharply demarcated ulcers with grayish white exudate surrounded by mucosal edema. Esophagogram was unsuitable to detect the lesions. They healed without complications within one to six weeks. Prolonged retention of capsules and direct irritation of esophageal mucosa by drug is thought to be the cause of the esophageal ulcer. The patients on doxycycline treatment should therefore be instructed to take their capsules with copious water and not just before going to bed.