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Synthesis, Anti-inflammatory, and Arginase Inhibitory Activity of Piceatannol and Its Analogs
문인수,Kongara Damodar,김진경,유승우,전종갑 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.3
The present study describes the synthesis of piceatannol (2) and its analogs (3–8) using Wittig-Horner reaction, Colvin rearrangement, and Sonogashira reaction as key steps and also evaluation of their inhibitory potency on the production of inflammatory mediator nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW-264.7 macrophages. Three compounds 7 (90.1%), 8 (60.8%), and 6 (55.2%) were found to potently inhibit NO production induced by LPS without affecting the viability of RAW-264.7 cells. In addition, their Arginase I and II inhibition activity was also evaluated. In this study, three compounds, i.e., compounds 2–4 were showed good inhibition activity to both arginase I and II. Of the synthesized compounds, compound 2 exhibited maximum inhibitory activity of 28% (arginase I) and 26% (arginase II) at 10 μM concentration followed by compounds 3 and 4 of 20 and 22% to arginase I, 22 and 23% to arginase II, respectively.
민관공동출자사업(제3섹터)에 관한 연구 : 한국과 일본의 사례분석 The Case Studies of Korea and Japan
文仁洙 慶一大學校 1996 論文集 Vol.13 No.1
The purpose of this study is to review the theories, to analyze the operational reality, and to suggest the activation strategies of the public-private partnership(the Third Sector). This study employed literature approach by using published research documents, data, and government publications. The scope of this study is to compare Korean case with Japanese one. This study, first, examined the theories of the Third Sector: concepts, typology, and background of the Third Sector. Second, this study reviewed the realities of the Third Sector in Korea and Japan in terms of behavioral, politico-administrative, and legal-institutional factors. Based upon the analysis, third, this study pointed out real problems and suggested activation strategies of the Third Sector. The interesting findings of this study are as follows. First, the absolute number of the Third Sector is too small. That is, total number of the Third Sector is 19, only 0.38% of total number of the Third Sector in Japan. Second, because of small amount of investment, the impact of the Third Sector on the regional economy is very weak. Third, the level of understanding of residents, firms, and public employees on the Third Sector is very low. Also, the support of government is not enough.
Novel CLCN1 Mutations and Clinical Features of Korean Patients with Myotonia Congenita
문인수,김향숙,신진홍,박영은,박규현,신용범,배종석,최영철,김대성 대한의학회 2009 Journal of Korean medical science Vol.24 No.6
Myotonia congenita (MC) is a form of nondystrophic myotonia caused by a mutation of CLCN1, which encodes human skeletal muscle chloride channel (CLC-1). We performed sequence analysis of all coding regions of CLCN1 in patients clinically diagnosed with MC, and identified 10 unrelated Korean patients harboring mutations. Detailed clinical analysis was performed in these patients to identify their clinical characteristics in relation to their genotypes. The CLCN1 mutational analyses revealed nine different point mutations. Of these, six (p.M128I, p.S189C, p.M373L, p.P480S, p.G523D, and p.M609K) were novel and could be unique among Koreans. While some features including predominant lower extremity involvement and normal to slightly elevated creatine kinase levels were consistently observed, general clinical features were highly variable in terms of age of onset, clinical severity, aggravating factors, and response to treatment. Our study is the first systematic study of MC in Korea, and shows its expanding clinical and genetic spectrums.