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오미자(五味子)(Fructus Schisandrae)가 흰쥐 해마신경세포의 저산소증 모델에서 세포사에 미치는 영향
주대환,신길조,문일수,Ju, Dae-Hwan,Shin, Gil-Cho,Moon, Il-Soo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : The purpose of this study was to investigate the effect of FS for the modulation of ROS and MMP in a hypoxic model of cultured rat cortical cells. Methods : For the effect of FS on the viability, FS was added to culture media (neurobasal supplemented with B27) and cell viability was measured by LDH assay. To investigate the effects of FS on ROS generation and MMP preservation, cells grown in FS-containing media were given a hypoxic shock(2% $O_2/5%$ $CO_2$, $37^{\circ}C$, 3 hrs) on DIV 10, stained with $H_2DCF-DA$(10 nM) and JC-1, respectively, and observed by fluorescent microscope. Results : 1. FS has a protective effect of cortical cells in both normoxia and hypoxia. 2. FS reduced the generation of ROS and this reduction was especially significant at 3 days after hypoxia. 3. FS was effective for the maintenance of MMP in hypoxia, and this efficacy was especially significant at 3 days after hypoxia. Conclusions : Taken together, these results indicate that FS attenuates ROS generation and MMP dissipation, which eventually protects from neuronal cell death in hypoxia.
문대환(Dae-Hwan Moon) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.7
본 연구는 자연기흉환자의 일반적 특성을 분석하여 유병률과 위험요인들의 예측인자의 관계를 확인한 후향적 코호트 조사연구이다. 자료 분석은 SPSS을 이용하여 전산 통계 처리하였다. 자연 기흉 발생의 영향요인으로 분석된 항목 중 위험요인 분석을 위해 일표본 T 검정, 이분형 로지스틱 회귀분석(Binary logistic regression analysis)을 실시하였다. 연구 결과로 자연기흉 환자의 평균 체질량지수는 20.2kg/㎡을 보였는데, 대한민국 남녀(25~29세)의 평균 체질량지수 23.3kg/㎡과 비교해 보았을 때 낮은 체질량지수를 보였다. 또한 유의미한 차이(t=-12.4, p =.001)를 보였다. 자연기흉 환자의 폐허탈 크기와 흡연과의 관련된 요인은 흡연하는 경우 폐허탈 정도가 40%이상 클 경우가 작은 경우보다 교차비 1.47배 높은 것으로 나타났다(OR=1.47, 95% CI=1.02-2.23, p =0.013) 결론적으로 낮은 체질량지수는 자연 기흉 발생률을 높이는 위험요인이며, 또한 흡연은 폐허탈의 크기를 증가시키는 위험요인이라고 하겠다. This study is a retrospective cohort survey study that analyzed the general characteristics of spontaneous pneumothorax patients to confirm the relationship between the prevalence of spontaneous pneumothorax and the predictors of risk factors. Data analysis was performed using SPSS. One-sample- t test and Binary logistic regression analysis were conducted to analyze risk factors among the items analyzed as influencing factors of spontaneous pneumothorax occurrence. As a result of the study, the average body mass index of spontaneous pneumothorax patients was 20.2kg/㎡, which was lower than the average body mass index of 23.3kg/㎡ of men and women (25-29 years old) in Korea. Also significant differences (t=-12.4, p =.001) has been shown. The factors associated with the size of the lung collapse and smoking in patients with spontaneous pneumothorax were found to be 1.47 times higher in the crossing ratio than those with a greater than 40% degree of lung collapse in smoking (OR=1.47, 95% CI=1.02-2.23, p =0.013). In conclusion, the low body mass index is a risk factor that increases the incidence of spontaneous pneumothorax, and smoking is also a risk factor that increases the size of lung collapse.