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생쥐에 이식된 암세포에 있어서의 Linoleic Acid의 암억제 효과
류태형,박성미,정해영,박건영,하재청 부산대학교 유전공학연구소 1992 분자생물학 연구보 Vol.8 No.-
ICR mice were transplanted with sarcoma 180 ascites tumor cells. Linoleic acid from Allium sativum for. Pekinase MAKINO was injected into the tumor bearing mice. Antitumor effect of the compound was investigated by using morphological and in situ hybridization means, Linoleic acid was effective in delaying the tumorigenesis process. However, the effects were appeared not to be associated with changes in selected oncogene expression.
알콜 유발성 지방간에 대한 Carnitine의 DOSE-DEPENDENT 효과
류태형 부산대학교 1988 자연과학논문집 Vol.45 No.-
The objective of this study was to determine whether the lipotropic effect of supplementary D,L-carnitine was dose dependent. Male Sprague-Dawley rats were fed a liquid diet in which 36% of the total calories were substituted by ethanol for 45 days. The ethanol diet, containing naturally 1.27㎍ of L-carnitine per 1 gram of diet, was fed as such or was further supplemented with 0.4%, 0.9%, 1.2%, and 1.6%(w/w, dry weight basis) D,L-carnitine. In both plasma and liver, result showed a definite inverse relationship between the levels of lipids and those of carnitines. The concentrations of total lipids and triglycerides was significantly reduced with increasing levels of supplementary carnitine while those of carnitine were significantly elevated. The changes in the plasma and hepatic concentrations of various classes of lipid and carnitine were inversely correlated ans were appeared to be progressive up to 0.8% D,L-carnitine supplementation. Therefore, it was concluded that the lipotropic effect of dietary carnitine is dose-dependent, and that the optimal supplementary level is 0.8% D,L-carnitine.
류태형(Tae-Hyong Rhew) 한국식품영양과학회 1985 한국식품영양과학회지 Vol.14 No.3
There is a trend that the total number of cancer cases is steadily increasing as the population grows. It has been estimated that 85% of the cancer rate in the U. S. is attributed to environmental factors. Among the enviromental factors, diet and nutrition appear to be related to the largest number of human cancers.<br/> Diet and nutrition might be related to cancer by several mechanisms. Food may contain a direct carcinogen or precursors that become carcinogens by spontanous reactions, or by host metabolism, or through the actions of microbial flora. Chemicals that cause cancers generally have reactive electrophilic centers which can combine with electron-rich atoms in nucleic acids and cause cancers by changing the genetic activity of the cells. A variety of factors in foods might be involved in the etiology of carcinogenesis.<br/> Chemicals in food that cause cancers include carcinogens of plants and animal origin and also those in drinking water. Other then these, fungal metabolites alcohol, asbestos, heavy metals, pesticides, and food additives might be included as food carcinogenesis. The method of cooking foods also might contribute to carcinogenesis. Some chemicals in foods act as promoters in carcinogenesis.<br/> Prevention of cancers by dietary practises have received much interest. Consumption of certain vegetables or cellulose can reduce carcinogenic activity of several compounds. A variety of antioxidants or micronutrients may be effective anticarciongens.<br/> Glutathione in the soluble fraction of the cells, is a major defense against oxidative and alkylating carcinogens. Recently anticarcinogenic activity of chlorophyll was demonstrated. Daily consumption of milk appears to effectively reduce stomach cancer.
류태형(Tae Hyong Rhew),박성미(Sung Mi Park),박건영(Kun Young Park),정해영(Hae Young Chung),하재청(Jae Chung Hah),이정규(Chung Kyu Lee) 대한약학회 1992 약학회지 Vol.36 No.6
To investigate the effect of ursolic acid on the expression of oncogenes in tumor cells of mice, sarcoma 180 ascites tumor cells were implanted into the left groin of ICR mice and the tumor bearing mice were treated with ursolic acid. The expression of oncogenes were measured by in situ hybridization method. Ursolic acid significantly reduced the expression of oncogenes in the tumor cells. Therefore, it can be said that the prestated anticarcinogenic effect of ursolic acid could be partly ascribed to the mechanism included in the oncogene''s transcription level.
실험계획법과 순차적 반응표면법을 이용한 선형 모터의 다중 목적 형상최적설계
류태형(Taehyung Ryu),유정훈(Jeonghoon Yoo) 대한기계학회 2009 大韓機械學會論文集A Vol.33 No.8
In many industries, the linear motor replaces the existing framework for linear transportation. Similar to other conventional motors, it is important to minimize the ripple of thrust and to maximize the thrust force of the linear motor. Because the two objectives are associated to each other, the multi-objective design process is necessary considering all objectives. This paper intends to optimize geometric parameters of the linear motor with two design objectives using design of experiments and sequential response surface method.
실험계획법과 순차적 반응표면법을 이용한 선형 모터의 다중 목적 형상최적설계
류태형(Taehyung Ryu),유정훈(Jeonghoon Yoo) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In many industries, the linear motor replaces the existing framework for linear transportation. Like existing motors, it is important to minimize the ripple of thrust and to maximize the thrust force of the linear motor. Because the two objectives are associated to each other, the multi-objective design process is necessary considering all objectives. This paper intends to optimize geometric parameters of the linear motor with two design objectives using design of experiments and the sequential response surface method