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스펙트로그램을 이용한 내전형 연축성 발성 장애와 근긴장성 발성 장애의 감별
노승호,김소연,조재경,이상혁,진성민,Noh, Seung Ho,Kim, So Yean,Cho, Jae Kyung,Lee, Sang Hyuk,Jin, Sung Min 대한후두음성언어의학회 2017 대한후두음성언어의학회지 Vol.28 No.2
Background and Objectives : Adductor type spasmodic dysphonia (ADSD) is neurogenic disorder and focal laryngeal dystonia, while muscle tension dysphonia (MTD) is caused by functional voice disorder. Both ADSD and MTD may be associated with excessive supraglottic contraction and compensation, resulting in a strained voice quality with spastic voice breaks. The aim of this study was to determine the utility of spectrogram analysis in the differentiation of ADSD from MTD. Materials and Methods : From 2015 through 2017, 17 patients of ADSD and 20 of MTD, underwent acoustic recording and phonatory function studies, were enrolled. Jitter (frequency perturbation), Shimmer (amplitude perturbation) were obtained using MDVP (Multi-dimensional Voice Program) and GRBAS scale was used for perceptual evaluation. The two speech therapist evaluated a wide band (11,250 Hz) spectrogram by blind test using 4 scales (0-3 point) for four spectral findings, abrupt voice breaks, irregular wide spaced vertical striations, well defined formants and high frequency spectral noise. Results : Jitter, Shimmer and GRBAS were not found different between two groups with no significant correlation (p>0.05). Abrupt voice breaks and irregular wide spaced vertical striations of ADSD were significantly higher than those of MTD with strong correlation (p<0.01). High frequency spectral noise of MTD were higher than those of ADSD with strong correlation (p<0.01). Well defined formants were not found different between two groups. Conclusion : The wide band spectrograms provided visual perceptual information can differentiate ADSD from MTD. Spectrogram analysis is a useful diagnostic tool for differentiating ADSD from MTD where perceptual analysis and clinical evaluation alone are insufficient.
노승호,이용우,박진수,이상혁,Noh, Seung Ho,Lee, Yong Woo,Park, Jin Su,Lee, Sang Hyuk 대한후두음성언어의학회 2017 대한후두음성언어의학회지 Vol.28 No.1
Laryngopharyngeal reflux disease (LPRD) is common in laryngologic practice. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms and physical findings. Major symptoms of LPRD include hoarseness, cough, reflux symptom and mild dysphagia. Even though LPRD is common, its diagnosis may be difficult, because its symptoms are nonspecific and the laryngeal findings are not always associated with symptom severity. In Recent study, 66.4% of Patient who has LPRD also associated with esophageal motility disorders. Esophageal achalasia is a disease of unknown etiology characterized by an absence of peristalsis in the body of esophagus and nonrelaxing hypertension of the lower esophageal sphincter. Common cause is loss of ganglion cells in Auerbachs plexus. The classic triad of symptoms in achalasia includes dysphagia, regurgitation and weight loss. LPRD and esophageal achalasia have similar symptoms but have different treatment of choice. The Differentiation diagnosis of theses disease is important and should be established by history, radiologic examination and endoscopic examination. We recently assessed a 59-year-old female patient who complained of an epigastric pain, dysphagia and chronic cough. LPRD was initially diagnosed on Laryngoscopic examination and Reflux Symptom Index, but patient was not relieved of any symptoms after treatment of Proton Pump Inhibitor for 3 months. After high resolution manometry, esophageal achalasia was finally diagnosed. We report this case regarding the diagnosis and treatment with review of literatures because we have to think about esophageal motility disorders as a differential diagnosis in laryngology.
노승호(Seung Ho Noh),김민범(Min-Beom Kim) 대한두개저학회 2018 대한두개저학회지 Vol.13 No.2
Dural arteriovenous fistula (DVAF) is a rare condition. However, it is important for not only otolaryngologists but also neurologists and neurosurgeons because it is the most common cause of pulsatile tinnitus and it can also be only clue to a potentially life-threatening disease such as intracranial vascular malformation. Diagnosis of dural arteriovenous fistula is usually delayed because it takes time to be enlarged enough to emerge radiologically. Pulsatile tinnitus with normal otoscopic examination and normal hearing threshold often presents a diagnostic challenge. Evaluation of patient with pulsatile tinnitus requires a detailed history, a comprehensive audiological evaluation with neuro-otological physical examination with imaging study. We report two patients with pulsatile tinnitus caused by an arteriovenous fistula of the transverse sigmoid sinus which was successfully treated with coil embolization and gamma kinfe.
이재덕,백대우,이정래,이민호,노승호,윤여경,안호정 ( Jae Duk Lee,Dae Woo Baek,Jeong Rae Lee,Min Ho Lee,Seung Ho Noh,Yeo Kyong Yoon,Ho Jeong Ahn ) 한국공업화학회 1995 공업화학 Vol.6 No.3
KS, JIS, ASTM 및 OECD의 계면활성제 생분해 공정시험법인 진탕배양법, 반연속식활성오니법, 연속식활성오니법을 이용해 APG의 생분해성을 조사하였다. Foam loss로 측정한 APG의 일차생분해도는 모든 시험법에서 100%인 것으로 나타나, APG는 하수처리장과 표층수의 조건에서 쉽게 분해됨을 확인할 수 있었다. 또한 OECD의 화학물질 생분해 평가법인 closed bottle test법으로 측정한 APG의 최종생분해도는 75% BOD_(28)/COD로, OECD에서 제시한 ready biodegradability limit인 60%를 초과하여, APG는 자연계에서 쉽게 분해되는 readily biodegradable한 물질인 것으로 확인되었다. The biodegradability of alkylpolyglucosides(APGs) was determined by shake culture tests, semicontinuous activated sludge test, and continuous activated sludge test mandated for testing the biodegradability of surfactants in OECD, ASTM, JIS and KS. APGs showed 100% foam loss in all tests. This means that APGs are degraded well not only in sewage treatment plant but in surface water conditions. In closed bottle test for determinating the ultimate biodegradability, APGs exceeded the ready biodegradability limit (60%) of OECD with 75% BOD_(28)/COD. APGs may therefore be considered as readily biodegradable under actual environmental conditions.
이재란,안석원,김한수,노승호 한국전과정평가학회 2001 한국전과정평가학회지 Vol.3 No.1
LG생활건가에서 생산되는 액체 주방세제의 환경성을 조사하기 위하여 전과정평가를 실시하였다. 제품별 전과정목록표를 도출하였으며, 이를 이용하여 수계생태독성, 지구온난화, 광화학스모그, 인간독성, 산성화, 부영양화에 대한 영향평가를 수행하였다. 그 결과, 제품 전과정 가운데 제품 계기단계에서 환경영향이 가장 높게 나타났고, 특히 수계생태독성에 의한 영향이 높게 나타났다. 주방세제의 환경지수에 영향을 미치는 원인물질을 찾아내고 개선물질로 대체하여 환경지수가 18% 감소한 제품을 개발하였다. With the kitchen detergents produced by LG Household & Healthcare, we performed life cycle assessment to examine their environmental properties. Life cycle inventories of kitchen detergent were drawn, and the impact assessment on six categories including aquatic eotoxicity, global warming, photochemical oxidant formation, human toxicity, acidification, and eutrophication was made using the inventories. As a result, it was found that environmental load is the highest at the end of life, and the worst impact category is aquatic ecotoxicity. We found the major ingredient determining environmental indicator and replaced it with more environmentally friendly material, so that the product of 18%-improved environmental indicator was developed.
임성현,박홍순,노승호,한상길,랑문정,윤여경 한국공업화학회 2003 공업화학 Vol.14 No.3
본 연구는 알킬 페놀류 8종(4-t-butyl phenol (BP), 4-n-pentyl phenol (PP), 4-n-hexyl phenol (HxP), 4-t-octyl phenol (t-OP), 4-n-heptyl phenol (HpP), b-nonyl phenol (b-NP). 4-n-octyl phenol (OP), 4-n-nonyl phenol (NP))을 액체 크로마토그래피(HPLC) 다이오드 배열 검출기(diode array detector, DAD)를 이용하여 동시분석하였다. 분리관은 역상 Cl8(250×4.6 mm), 이동상은 물과 메탄올을 사용하여 기울기 용리(gradient)하에서 알킬 페놀류의 알킬 길이에 따라 분리하였으며, 알킬 페놀류의 검량선을 도시한 결과 좋은 직선성이 보였다. 상기 분석법으로 국내 유통 중인 주방 세제류 내 알킬 패놀류를 분석한 결과 불검출 되었고, 이때 검출한계는 주입량(10 μL) 대비 1 pg이었다. 4-t-butyl phenol (BP), 4-n-pentyl phenol (PP), 4-n-hexyl phenol (HxP), 4-1-octyl phenol (t-OP), 4-n-heptyl phenol (HpP), b-nonyl phenol (b-NP), 4-n-octyl phenol (OP), and 4-n-nonyl phenol (NP) were simultaneously separated by a high performance liquid chromatography (HPLC) with UV diode array detector(230 nm, f60 nm, 280 nm) using an octadecylsilica column (Cl8, 250×4.6 mm) and water/methanol gradient solution. The calibration curves of alkyl phenols showed a good linear relationship, and the recoveries were over 95%. With the detection limit of 1pg for alkyl phenols with respect to the injected amount, alkyl phenols were not detected in tile dishwashing detergents that were available on the market.