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이현아,남궁은경,기신영,임건일,정성환,어수택,박춘식 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.2
High dose corticosteroids are extensively used in the management of acute bronchospasm due to asthma or other allergic phenomena. Corticosteroids, particularly hydrocortisone and methylprednisolone, have been rarely implicated in ansphylactic reactions in adolescents and adults. There are 14 documented cases in the literature. The first documentation of this type of adverse reaction was by Mendelson et al. We reported herein an methyprednisolone induced bronchospasm in a 60 year old male with bronchial asthma. This patient had no history of atopy or allergic disease and had never reacted adversely to any drug. He was given methyl- prednisolone sodium succinate 62.5 mg intravenously. Five minutes after the injection, he developed dyspnea, palpitation and sweating which were relieved by pheniramine maleate and terbutaline sulfate. He was able to tolerate oral prednisone without problem. Intradermal tests were performed with meth- ylprednisolone sodium succinate, hydrocortisone sodium succinate, methylpred- nisolone acetate to concentrations of 1 and 10 mg/dl, saline and histamine into the forearm. Positive reaction was observed with all concentrations of methylprednisolone sodium succinate and hydrocortisone sodium succinate. The skin test with methylprednisolone acetate was negative. In conclusion, the succinate compound may act as an agents inducing bronchospasm in this case.
Two Cases of Nonmenstrual Toxic Shock Syndrome with Review of the Literature
Shin, Won Yong,Namkoong, Eun Kyung,Woo, Jun Hee 대한감염학회 1995 감염 Vol.27 No.3
포도상구균에 의한 감염증 가운데 독소에 의한 감염질환으로 손꼽히는 것이 Toxic Shock Syndrome(TSS)이다. TSS는 흔히 menstrual tampon을 사용하던 여성에서 TSST-1으로 알려진 독소로 인하여 과거에 폭발적으로 발생하여 상당한 문제로 등장하였던 질병으로 우리나라에서는 여러가지 이유로 흔하게 보고되지 않은 질환이며, 최근에는 menstruation과 상관없이 발병하는 감염증으로, 저자들은 상처감염후에, 연조직 감염후에 발생한 2예의 TSS를 치험하였기에 문헌고찰과 함께 보고하는 바이다. Toxic shock syndrome (TSS) is a multisystem disease presenting with high fever, a sunburn rash that subsequently desquamated, and hypotension primarily in white young menstruating women caused by toxin producing strains of Staphylococcus aureus. Later, the cases of non-menstrual TSS increased relatively compared with menstrual TSS. TSS is a clinical diagnosis, the establishment of which rests upon the fulfillment of clinical criteria. The lack of specificity of the case definition poses distinct problems for the clinician. Therefore the incidence of TSS seems to be less than we can aware. We describe herein two cases of TSS with review of the literature; one is associated with wound infection, the other with soft tissue infection in left nasal cavity.
한연석,진재용,남궁은경,김기업,어수택,김용훈,박춘식,황정화,김현조,염욱 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
A 57-year-old Korean woman was presented with paroxysmal cough and exertional dyspnea. Her chest P-A showed mutiple small nodular densities predominatly on the right lower lung fields and HRCT, also, showed multiple bronchiolar nodules, branching linear densities and air-trapping suggesting bronchiolitis, Microbiologic tests did not suggest any infectious causes of her chest lesions. The diagnosis of black dust-associated bronchiolitis was established by open lung biopsy showing interstitial fibrosis, anthracoid pigmentations on terminal and respiratory bronchioles, and a lot of silica-like particulate structure on the wall of bronchioles. She didn't smoke or had occupation that could cause dust inhalation. Woodsmoke was suggested from history as the possible cause of her pathology.