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임건일,박춘식 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Background: Idiopathic interstitial pneumonia(IIP) is histologically divided into usual interstitial pneumonia(UIP), desquamative interstitial pneumonia(DIP), acute interstitial pneumonia(AIP), and nonspecific interstitial pneumonia/fibrosis(NSIP). An alveolitis and a derangement of alveolar wall are prebably followed by fibrosis. In this process, interleukin-6(IL-6), one of proinflammatory cytokines, is presumed to decrease fibrotic reaction. In IIP, NSIP has a better prognosis and a lesser fibrosis than UIP. The purpose of the study was to compare concontrations of IL-6 between UIP and NSIP and define the source of IL-6 synthesis. Method: Six patients with NSIP and 13 patients with UIP were confirmed by open lung biopsy. Bioactivity of IL-6 in bronchoalveolar lavage fluid(BALF) was measured by an bioassay using B9 cell proliferation Spontaneous and lipopolysaccaride(LPS)-stimulated production of IL-6 by BAL cells were compared between two groups. Biopsy specimens from patients with NSIP were freezed and cryosectioned. The tissue slides were fixed in acetone. They were reacted with primary antibodies including anti-IL-6, secondary antibody, and tertiary antibody, in order. The slides stained by immunohistochemistry were obseved by light microscope. Results: 1)Mean concentration of IL-6 of BAL fluid of NSIP group was significantly higher than that of UIP. 2)Spontaneous production of IL-6 by BAL cells of NSIP was significantly higher than that of UIP. 3) Ratio of spontaneous to LPS stimulation in IL-6 production by BAL cells was higher in NSIP than UIP. 4) By immunohistochemistry, IL-6 was strongly stained on interstitial monocytes, interstitial lymphocytes and alveolar epithelial cells, but weakly stained in intraalveolar macrophages. Conclusion; IL-6 production in NSIP was enhanced more than that in UIP. The origin of IL-6 seems to be interstitial cells and the alveolar epithelium and not to be cells present in BALF.
Pathogenesis, Management and Prevention of Atypical Femoral Fractures
임건일,정승효 대한골대사학회 2015 대한골대사학회지 Vol.22 No.1
Much attention has been paid to the relationship between atypical femoral fractures (AFF) and use of bisphosphonates (BPs). While a significant cause-effect relationship was not established in earlier studies, more recent data shows a growing relationship between AFF and BPs use. The definition of an ‘AFF’ has also undergone significant changes. This review briefly summarizes the definition, pathogenesis, and management of AFF.
경북 구미시 종합병원에서 진단된 토착형 삼일열 말라리아 21예
임건일,박헤정 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3
Background: Malaria is estimated to have a worldwide incidence of more than 100 million clinical cases and approximately 1 million deaths per year. Korea, although previously known as an endemic area of tertian malaria(Plasmodium vivax), has been considered free from malaria as there had been no report on indigenous cases since 1984. However, since the reemergence of indigenous vivax malaria in 1993, the number of cases of malaria have recently increased. We analyzed 21 cases of malaria who were treated in Soonchunhyang Gumi hospital with regard to epidemiology, clinical manifeastations, and laboratory findins. Methods: We retrospectively analyzed data of 21 cases of malaria treated in our hospital. Results: All cases were indigenous. All patients had fever. Peripheral blood smear revealed Plasmodium vivax. Paju-gun/Munsan(8 cases) was the most prevalent area. 4 cases were anemia(hemoglobin <10 g/dL) and 15cases were thrombocytopenia ( platelet < 100,000/㎕). Conclusion: In patients, the most common labaratory findings were thrombocytopenia. As cases of indigenous malaria in Korea are increasing, early diagnosis, treatment, and prevention of malaria are important.
후두절제술을 시행받았던 환자에게 기관절개부위로 흡인된 기관지내 금속관의 굴곡성 기관지내시경을 이용한 제거 1례
임건일,박혜정 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Most of foreign body aspiration is done via oral cavity. When the foreign body is found in airway, they try to remove it by rigid or flexible bronchoscopy. A 79-year-old man was admitted with foreign body aspiration via tracheostomy site. Chest X-ray showed metallic tube in lower trachea. We did flexible bronchscopy and removed it. After removal, patient's symptoms were relieved. We report a case of foreign body removal by flexible bronchoscopy with brief review of the literature.
경북 구미지역 대학병원에서 호흡기 장애판정을 받은 환자의 임상 소견
임건일,황헌규,정은정 순천향대학교 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.2
Legal pulmonary disability in Korea is decided for chronic respiratory patients who have been diagnosed for a year or more, and the patients haven’t gotten better after more than 2 months of sufficient treatment. The purpose of this study was to investigate the clinical features and progress of those patients who have been diagnosed as having pulmonary disability. We reviewed retrospectively the medical records of the patients who had been decided as having pulmonary disability at a secondary university hospital from 2003 to 2010. The number of enrolled patients was 15 (male:female = 8:7) and their mean age was 62.4 ± 12.1 years. Of them,the number of patients with a class 1 pulmonary disability were 4 (27%), class 2 patients were 3 (20%), and class 3 patients were 8(53%). Their major underlying diseases were tuberculous destroyed lung (n = 7, 47%), chronic obstructive pulmonary disease (n =5, 33%), and bronchiectasis (n = 2, 13%). After decision, 4 patients died: 2 patients were class 1, 1 was class 2, and 1 was class 3. All of these patients died of their underlying pulmonary diseases or combined pneumonia. Further studies are needed to observe the clinical progress and prognosis of patients with pulmonary disability by performing long-term follow-up for a large number of patients.
임건일,정진태 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2
Background; Endobronchial tuberculosis is one of serious complication of pulmonary tuberculosis and may result from rupture of infected lymph nodes into the bronchial wall or from lymphatic spread to the mucosal surface of the bronchial tree. It is a major cause of morbidity, as it heals with concentric scarring, resulting in bronchial stenosis, atelectasis, and frequently recurring pneumonia. The clinical and bronchoscopic features of endobronchial tuberculosis retrospectively investigated. Materials and methods; Total 86 cases with endobronchial tuberculosis out of 666 subjects, who had flexible bronchoscopic examination at the department of internal medicine, Soonchunhyang Gumi hospital during the period between the beginning of March 1996 and October 2003, were included in the study. The diagnostic criteria used for endobronchial tuberculosis included the cases proven as tuberculosis by culture of bronchial washing and histologic features of biopsy specimen among patients with endobronchial lesion on bronchoscopy. Clinical information was retrospectively gathered from all available medical records. Results; The peak incidence of endobronchial tuberculosis coourred in the third decade. The incidence of female was 4.1 times higher than that of male. Chronic cough was the most common chief complaint(41.9%). Parenchymal infiltration and/or consolidation of lung was the most common chest X-ray finding(53.5%). Caseaous necrosis was the most common bronchoscopic finding(37.2%). The most frequently involved bronchus was the right upper lobar bronchus(31.3%) and in case of including left upper bronchus, involvement of upper lobar bronchus was 53.4%. Conclusion; The annual incidence of endobronchial tuberculosis didn't decrease from the end of 20th century to the beginning of 21st century. Thus, when young female patients complain of chronic cough, bronchoscopy should be considered to differentiate endobronchial tuberculosis.