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김혜연,윤우준,신민호,권순석,안혜란,최성우,이영훈,조동혁,이정애,Kim, Hye-Yeon,Yun, Woo-Jun,Shin, Min-Ho,Kweon, Sun-Seong,Ahn, Hye-Ran,Choi, Seong-Woo,Lee, Young-Hoon,Cho, Dong-Hyeok,Rhee, Jung-Ae 대한예방의학회 2009 예방의학회지 Vol.42 No.5
Objectives : Knowledge about the management status of diabetic melitus (DM) is essential to improve diabetic management. Moreover, low income is associated with poor adherence to treatment and increased mortality. This study was performed to evaluate the management status of DM in low-income patients in a rural area. Methods : We enrolled 370 patients with type 2 DM living in Gokseong county, JeollaNamdo. A well-trained examiner measured the height, weight, waist circumference, blood pressure, total cholesterol, triglyceride, high density lipoprotein cholesterol, fasting blood sugar and glycosylated hemoglobin (HbA1c) levels. Carotid ultrasonography was used to measure carotid artery carotid artery intima media thickness (IMT) and plaque. anklebrachial index (ABI) was used to evaluate peripheral artery disease. A fundoscopic examination was performed to evaluate diabetic retinopathy. A history of diabetes complications and health-related questionnaires were also completed. Results : The age of diabetic subjects was 68.7$\pm$8.7 years and the duration of diabetes was 8.9$\pm$8.2 years. Most (63.5%) had hypertension, and 45.7% had triglycerides below 150 mg/dl, 38.1% had low density lipoprotein cholesterol (LDL) cholesterol below 100 mg/dl, 48.7% had urine albumin to creatinine ratio (UACR) below 30 mg/g. Less than half (45.9%) achieved the goal of HbA1c less than 7% suggested by the American Diabetes Association (ADA). 10.6% had peripheral vascular disease, 11.9% had retinopathy, and 60.8% had chronic kidney disease. Conclusions : DM management in low income patients is very poor and requires further work to improve.
자궁경부암에서 Cdc25A, Cdc25B 및 Cdc25C의 발현
김혜연 ( Hye Yeon Kim ),김재욱 ( Jae Wook Kim ),김세광 ( Sei Kwang Kim ),김영태 ( Young Tae Kim ),김재훈 ( Jae Hoon Kim ),김성훈 ( Sung Hoon Kim ),김상운 ( Sang Wun Kim ),윤보성 ( Bo Sung Yoon ),남은지 ( Eun Ji Nam ),조혜진 ( Hye 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10
목적: 본 연구는 자궁경부암에서 세포주기 조절인자인 cell division cycle (Cdc) 25A, Cdc25B 및 Cdc25C 발현 양상을 정량적으로 측정하여 이들이 자궁경부암의 발암과정에서 어떠한 역할을 하는지를 규명하며 아울러, 자궁경부암의 여러 다른 임상적 및 병리학적 예후 인자와 상관관계가 있는지를 연구하고자 하였다. 연구 방법: 본원 산부인과에서 2000년 2월부터 2005년 3월까지 수술적 치료를 받은 환자를 대상으로 하여 신선 자궁경부 조직을 얻었다. 역전사 중합요소 연쇄 반응과 Western blot analysis를 이용하여 각각 Cdc25A, Cdc25B 및 Cdc25C의 mRNA와 단백질 발현 양상을 확인하였다. 결과: 자궁경부암 조직에서의 Cdc25A, Cdc25B 및 Cdc25C의 mRNA 발현은 정상 자궁경부 조직보다 모두 통계학적으로 유의하게 높았으며 (p=0.02, 0.01, 0.02), Cdc25A, Cdc25B 및 Cdc25C의 단백질 발현 양상도 자궁경부암 조직에서 정상 자궁경부 조직에 비해 모두 통계학적으로 유의하게 높은 결과를 보였다 (p=0.01, 0.02, 0.01). 또한 자궁경부암에서의 Cdc25A, Cdc25B 및 Cdc25C의 mRNA 발현과 단백질 발현을 임상적 및 병리학적 예후 인자들에 따라 비교한 결과 환자의 연령과 Cdc25B mRNA 발현 (p=0.03), 세포 형태와 Cdc25C mRNA 발현 (p=0.04) 사이에서는 통계학적으로 유의한 상관관계를 보였으나 그 외의 인자들인 세포아형태, 혈청내 squamous cell carcinoma antigen (SCC Ag) 수치, 유세포 분석법을 통한 DNA flow cytometry 결과, 림프절 전이, 림프혈관 침범, 인유두종 바이러스 감염 등과는 통계학적으로 유의한 상관 관계를 보이지 않았다. 결론: 본 연구 결과에 따르면 Cdc25A, Cdc25B 및 Cdc25C가 대조군인 정상 자궁경부 조직에 비해 자궁경부암 조직에서 통계학적으로 유의하게 높게 발현됨을 확인할 수 있었다. 따라서, 자궁경부암의 발생기전에 Cdc25A, Cdc25B 및 Cdc25C가 중요한 역할을 할 가능성을 제시하였다. 또한 Cdc25A, Cdc25B 및 Cdc25C의 mRNA와 단백질 발현은 환자의 연령이 50세 이상인 경우에 Cdc25B mRNA 발현이 유의하게 높았으며 (p=0.03), 세포형태에 따라 분류하였을 때 편평상피세포암에서 Cdc25C mRNA 발현이 통계학적으로 유의하게 높았다 (p=0.04). 그러나, 다른 예후 인자들과는 통계학적으로 유의한 상관관계를 보이지 않았다. 향후 Cdc25A, Cdc25B 및 Cdc25C가 자궁경부암의 유용한 예후 인자로 사용되기 위해서는 향후 생존율과 연관된 연구가 추가로 뒷받침되어야 할 것으로 생각된다. Objective: This study was undertaken to quantitatively detect Cdc25A, Cdc25B and Cdc25C in cervical carcinoma and determine the relationship between the expression of mRNA and protein of cell division cycle (Cdc)25 phosphatase and various clinicopathologic prognostic factors of cervical carcinoma. Methods: 39 patients diagnosed with cervical carcinoma between February 2000 to March 2005 and 10 patients with benign gynecologic disease were enrolled in this study. A reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis were used to analyze the expression of Cdc25 phosphatase mRNA and protein in fresh invasive cervical cancer tissue and normal cervix tissue. Results: The mRNA expressions of Cdc25A, Cdc25B and Cdc25C in the cancer tissues were significantly greater than in the control (p=0.02, 0.01, 0.02), respectively. A Western blot analysis yielded same results (p=0.01, 0.02, 0.01). There were also significant relationships between the age and the Cdc25B mRNA expression (p=0.03), between the cell type and the Cdc25C mRNA expression (p=0.04). However, other clinicopathologic prognostic factors including stage, subtype, SCC Ag level, DNA flow cytometry, lymph node metastasis, lymphovascular space invasion and HPV positivity were not statistically significant. Conclusion: Our results show that Cdc25A, Cdc25B and Cdc25C expression levels were significantly greater in cervical cancer patient group than in those of control group. Thus Cdc25 phosphatase might play an important role in carcinogenesis of cervical carcinoma. Further studies based on the correlation between Cdc25 phosphatase and survival rate would be need to support Cdc25 phosphatase as a prognostic factor of cervical carcinoma.
어휘접근법 기반의 어휘지도가 초등영어 학습자의 어휘 활용 능력에 미치는 영향
김혜연(Kim Hye yeon),김혜련(Kim Hye Ryun) 한국초등영어교육학회 2015 초등영어교육 Vol.21 No.4
The present study aims to examine the effects of vocabulary teaching based on the lexical approach on Korean primary school students' English vocabulary use and application in contextualized situations. For this purpose, 104 students in 4th grade participated in the study during the course of their regular English lessons twice a week for ten weeks. Two classes were taught using lexical approach activities, and two were taught with an emphasis on single word meaning. The results of the study showed that on the short-term test administered at tenth week, there was no significant difference between the two groups regarding vocabulary ability. However, the delayed test conducted at week five after the post-test showed a statistically significant difference between the groups with the students being taught using the lexical approach remembering more of the words and using them appropriately. This results suggest that teaching English vocabulary using the lexical approach is an effective way to build long-term memory and enable students to use words appropriately in any given situation.
20대 여대생의 체질량지수에 따른 하체 체형관리 인식 및 만족도 연구
김혜연 ( Hye-yeon Kim ),이인희 ( In-hee Lee ) 한국미용예술경영학회 2012 미용예술경영연구 Vol.6 No.4
In this study I analyzed using survey in order to develop custom-built program according to customers' individual tendency and distinct characteristic in the rapidly growing controlling body type service part and to supply marketing's basic data understanding the satisfaction and controlling lower body type of women in their 20s according to BMI from 180 Seoul Women' s University students. 89.1 % from the whole thought that women need to get lower body type controlling, and answered the ‘thigh’ as the most important part for an attractive lower body, the hardest lower body part to get rid of the fat, and the part that needs to get body type controlling. From the women in their 20s, only 13.9% answered that they have experienced using the obesity care center for controlling their lower body type, and 86.1% answered that they don't have any experience. If we look at the actual situation of the use of body type care center, the most reason for getting lower body type controlling was ‘to make a balanced body type' for 47.8%. The number of time using the body type care center was the highest on ‘more than once a week' for 47.8%, and the period using the body type care center was the highest on ‘2-3 months' for 52.2%. The reasonable controlling time was the highest on ‘1-2 hours' for 56.5%, and the reasonable cost for a single surgical procedure was the highest on ‘5-7 hundred thousand won' for 56.5%.