제 2 발표장 : 나노결정 구리의 기계적 성질의 복합재료모델에 관한 연구

김형섭,조성석,천병선 ( H . S . Kim,S . S . Cho,B . S. Chun ) 한국복합재료학회 1996 한국복합재료학회 학술발표대회 논문집 Vol.- No.2

연마방법에 따른 복합레진의 활택도에 관한 연군 -Atomic Force Microscope를 이용한 연구

김형섭,우이형,Kim, Hyeong-Seob,Woo, Yi-Hyung 대한치과보철학회 1997 대한치과보철학회지 Vol.35 No.4

This study was undertaken to compare by Atomic Force Microscope the effects of various finishing and polishing instruments on surface roughness of filling and veneering composite resins. Seven composite resins were studied : Silux Plus (3M Dental Products, U.S.A.), Charisma (Heraeus Kulzer, Germany), Prisma THP (L.D.Caulk, Dentsply, U.S.A.), Photoclearfil (Kuraray, Japan), Cesead (Kuraray, Japan), Thermoresin LC (GC, Japan), Artglass (Heraeus Kulzer, Germany). Samples were placed and polymerized in holes (2mm thick and 8.5mm in diameter) machined in Teflon mold under glass plate, ensuring excess of material and moulded to shape with polyester matrix strip. Except control group (Polyester matrix strip), all experimental groups were finished and polishied under manufacturer's instructions. The finishing and polishing procedure were : carbide bur (E.T carbide set 4159, Komet, Germany), diamond bur (composite resin polishing bur set, GC, Japan), aluminum-oxide disc (Sof-Lex Pop-On, 3M Dental Products, U.S.A.), diamond-particle disc (Dia-Finish, Renfert Germany), white stone bur & rubber point( composite finishing kit, EDENTA, Swiss), respectively. Each specimens were evaluated for the surface roughness with Atomic Force Microscope (AutoProbe CP, Park Scientific Instruments, U.S.A.) under contact mode and constant height mode. The results as follows : 1. Except Thermoresin LC, all experimental composite resin groups showed more rougher than control group after finishing and polishing(p<0.1). 2. A surface as smooth as control group was obtained by $Al_{2}O_{3}$ disc all filling composite resin groups except Charisma and all veneering composite resin groups except Thermoresin LC(p<0.05). 3. In case of Thermoresin LC, there were no statistically significant differences before and after finishing and polishing(p>0.1). 4. Carbide bur, diamond bur showed rough surfaces in all composite resin groups, so these were inappropriate for the final polishing instruments.

우울증 치료에 있어서 약물의 Combination과 Augmentation 전략

김형섭,Kim, Hyeong-Seob 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major limitations of antidepressant therapy. One is the delayed onset of improvement and another is partial response. In order to address these clinical dilemmas, many psychiatrists more commonly employ add-on therapy. In past, the practice of using multiple drugs to enhance treatment response was called polypharamcy, and was disparaged as poor clinical practice. However, with improved understanding of how drugs affects the central nervous system and increased communication in journals and on computer networks about the relative merits of specific combinations, the scientific basis for the combining drugs is being defined. Indeed, the use of multiple medications as a stratege to enhance response has become both acceptable and widespread now a days. It is now referred to more positively as add-on therapy, co-medication, combination therapy, or drug augmentation. Thus, as the methods of practical strategies for treatment of depression, switching classes antidepressant drugs, combination therapy, augmentation strategies and brief treatment algorithm will be presented with items of considerations. However, when combination of drugs being tried, knowledges about the action of mechanism, pharamcokinetics, and pharmacodynamics are essential to cope with the possible adversive reactions and to get the appropriate responses for the treatment of depressive symptoms.

PSRC 기둥공법의 현장 적용성 평가

김형섭,이창남,이승환,Kim, Hyoung-Seop,Lee, Change-Nam,Lee, Seung-Hwan 한국공간구조학회 2012 한국공간구조학회지 Vol.12 No.3

『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 따른 대시호탕(大柴胡湯) 투여와 압출치료를 병행하여 호전된 성인 여드름 증례보고

김형섭,Kim, Hyeong-Seop 대한상한금궤의학회 2017 대한상한금궤의학회지 Vol.9 No.1

Objectives : The purpose of this case report is to report the effect of Daesiho-tang on adult acne by Shanghanlun provisions with extrusion therapy. Methods : According to diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung Gyeolhyung and treated by Daesiho-tang with extrusion therapy. The result of administrations were evaluated by Korean Acne Grading System(KAGS), Korean Skindex-29, and change of clinical symptoms. Results : After administration of Daesiho-tang for 150 days with weelky extrusion therapy, KAGS improved from grade 4 to grade 1, Skindex-29 improved from 67.93 to 15.51, and patient was very satisfied with the treatment. No serius treatment-related adverse events were reported. Limitations : This case is only one case that the level of evidence is weak. Two interventions were used together and the duration of photo was uneven. Conclusions : The patient almost recovered from acne treated by Daesiho-tang according to diagnostic system based on Shanghanlun provisions with extrusion therapy. This is the first case report that suggests '熱結在裏' on the number 136 provision of Shanghanlun means fever that is always present in chronic skin lesions.

폴리에틸렌, 폴리프로필렌, 폴리스티렌 이성분 혼합물의 유변학적 성질 및 다이 팽윤

김형섭,김상용,전붕수,Kim, Hyeong-Seop,Kim, Sang-Yong,Jeon, Bung-Su 한국섬유공학회 1994 한국섬유공학회지 Vol.31 No.10

A study has been made on the die-swell and rheological properties of bicemponent polymer blends of low density polyethylene(PE), polypropylene(PP) and polystyrene(PS); PE/PP, PE/PS, and PP/PS. In the case of PE/PP blends the continuous phase transferred from PE to PP at the PE content of 60wt%. Meanwhile the PE/PS and PP/PS blends the continuous phase transferred from PE to PS and from PP to PS at the PS content of 60wt%. respectively. The die-swelling ratio. normal stress difference(N1) and dynamic shear viscosity of PE/PP blends appear, to show same tendency by chaneine the blend-ratios. For the cases of both PE/PS and PP/PS blends, where PE and PP are in the continuous phase, the die-swelling ratios increase as the N1 increases but decrease as the dynamic shear viscosity increases. But N1 of the PS has been found not to contribute to the die-swelling ratios when PS is in the continuous phase.

한국인의 상악 유치악 치열 및 무치악 치조제에 관한 삼차원적 연구

김형섭,신상완,Kim Hyeong-Seop,Shin Sang-Wan 대한치과보철학회 2005 대한치과보철학회지 Vol.43 No.2

Statement of problem. In Korea, the preliminary impression trays for dental and edentulous maxillae are manufactured on the base of the statistical value of Westerners. There had been less study on the dental and edentulous arches of Koreans. Purpose. The purpose of this study was to evaluate an average dental cast, preliminary impression trays, three-dimensional relation of dental and edentulous maxilla of Koreans Material and methods. The subjects for this study were 173 dental casts of maxilla (dental: 52, edentulous : 146) with ages $18\{\sim}60$ years old. Each of the master casts was measured 69 measuring points on the dental cast or maxilla, and 46 measuring points on the edentulous cast of maxilla with three-dimensional digital measuring machine. Each measuring points were analysed and were overlapped, that three dimensional dental graphic manufactured by CAD/CAM system. Results. 1. A standard of distribution to alveolar bone were width between left and right buccal border lines of the standard 3/4 line. The mean value of dental and edentulous casts were 67.27mm, 63.49mm respectively. 2. Morphological classification of dental casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 17%, 16%, 67%, respectively. Dimensional classification of the dental casts were divided into five groups of less than 63mm, 63 up to 65mm, 65 up to 67mm. 67 up to 69mm, more than 69mm, respectively. 3. Morphological classification of edentulous casts were divided into three groups or V-shape, O-shape, U-shape, that proportion of distribution were 18%, 17%, 65%, respectively Dimensional classification of the edentulous casts were divided into five groups of less than 57mm, 57 up to 61mm, 61 up to 65mm, 65 up to 69mm, more than 69mm, respectively. 4. Mean dental and edentulous cast of maxilla were overlapped, the proportion of bone resorption to alveolar bone is higher than that of palatal bone, its difference were higher anterior 2/4 area than posterior 3/4 area. Conclusion. It obtains information of preliminary impression trays for dental and edentulous maxilla of Koreans.

이온보조반응법으로 처리한 알루미나 코아의 인장결합강도에 관한 연구

김형섭,우이형,권긍록,최부병,최원국,Kim, Hyeong-Seob,Woo, Yi-Hyung,Kwon, Kung-Rock,Choi, Boo-Byung,Choi, Won-Kook 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.5

This study was undertaken to evaluate the tensile bond strength of In-Ceram alumina core treat-ed by ion assisted reaction(IAR). Ion assisted reaction is a prospective surface modification technique without damage by a keV low energy ion beam irradiation in reactive gas environments or reactive ion itself. 120 In-Ceram specimens were fabricated according to manufacturer's directions and divided into six groups by surface treatment methods of In-Ceram alumina core. SD group(control group): sandblasting SL group: sandblasting + silane treatment SC group: sandblasting + Siloc treatment IAR I group: sandblasting + Ion assisted reaction with argon ion and oxygen gas IAR II group: sandblasting + Ion assisted reaction with oxygen ion and oxygen gas IAR III group: sandblasting + Ion assisted reaction with oxygen ion only For measuring of tensile bond strength, pairs of specimens within a group were bonded with Panavia 21 resin cement using special device secured that the film thickness was $80{\mu}m$. The results of tensile strength were statistically analyzed with the SPSS release version 8.0 programs. Physical change like surface roughness of In-Ceram alumina core treated by ion assistad reaction was evaluated by Contact Angle Measurement, Scanning Electron Microscopy, Atomic Force Microscopy; chemical surface change was evaluated by X-ray Photoelectron Spectroscopy. The results as follows: 1. In tensile bond strength, there were no statistically significant differences with SC group, IAR groups and SL group except control group(P<0.05). 2. Contact angle measurement showed that wettability of In-Ceram alumina core was enhanced after IAR treatment. 3. SEM and AFM showed that surface roughness of In-Ceram alumina core was not changed after IAR treatment. 4. XPS showed that IAR treatment of In-Ceram alumina core was enabled to create a new functional layer. A keV IAR treatment of In-Ceram alumina core could enhanced tensile bond strength with resin cement. In the future, this ion assisted reaction may be used effectively in various dental materials as well as in In-Ceram to promote the bond strength to natural tooth structure.

제 1형 Trichorhinophalangeal 증후군

김형섭,심우영,허충림 ( Hyoung Seob Kim,Woo Young Sim,Choong Rim Haw ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Trichorhinophalangeal syndrome(TRPS) was first described in 1966 by Giedion. It is a rare genetic disease and divided into two groups : TRPS type I and TRPS type II. TRPS type I is an autosomal dominant inherited disorder, defined by three characteristic findings : first, sparsely distributed brittle and slow-growing scalp hair, second, a bulbous pear-shaped nose with an elongated philtrum, third brachydactyla with angular deformities. The characteristic radiological features of the hands include cone shaped epiphysis of the proximal interphalangeal joints. Most TRPS type II is sporadic and shows multiple exosteosis, mental retardation and microcephaly in addition to the three chracteristic findings of TRPS type I . A 20-year-old female visited our department for the evaluation of her sparse, slow-growing scalp hair. She also had a bulbous pearshaped nose, ulnar deviated fingers and shortened both hallux. Some relatives of patients show similar symptoms of scalp hair. A Radiologic aly, histopathologic aly and chromosomal study were done, and we established the diagnosis, TRPS type I. (Kor J Dermatol 1997;35(2): 344-349)

『상한론(傷寒論)』 처방에서 감초(甘草) 용량의 안전성 및 임상 사용에 대한 문헌 고찰

김형섭,이숭인,Kim, Hyeong-Seop,Lee, Soong-In 대한상한금궤의학회 2016 대한상한금궤의학회지 Vol.8 No.1

Objectives : The purpose of this paper is to find out the safe dose and clinical use for administration of Glycyrrhizae Radix in Shanghanlun(傷寒論). Methods : Web-databases(OASIS, NDSL, Pubmed, Google) were searched with keywords including 'Licorice', 'Pseudoaldosteronism', 'Glycyrrhizin', 'Testosterone' on 14/10/2016. The searched about 40 papers and books were reveiwed. Results : Glycyrrhizin(GL) and 3-monoglucuronyl glycyrrhetinic acid(3MGA) in Glycyrrhizae Radix are found to be the main compounds vulnerable for inducing pseudoaldosteronism. The dose range of Glycyrrhizae Radix in Shanghanlun prescriptions is from 0.25 g to 12 g as a daily administration, and this dose satisfies the guidelines of WHO, European Union, ABC etc. And risk factors contributing for personal sensitivities are old age(>60), female sex, liver dysfunction, hypokalemia, prolonged gastrointestinal transit time, anorexia nervosa, decreased 11-${\ss}$-hydroxysteroid dehydrogenase-2 activity and hypertension. Conclusions : As a result, dose of Glycyrrhizae Radix in Shanghanlun(傷寒論) is safe. However, the personal sensitivity and unexpected drug interactions are independent from doses of GL, so doctors should monitor those risk factors and symptoms of pseudoaldosteronism when administering Glycyrrhizae Radix.