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Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer
김진원,조성엽,채지수,김지원,김태용,이근욱,오도연,방영주,임석아 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose Microsatellite instability (MSI) status may affect the efficacy of adjuvant chemotherapy in gastric cancer. In this study, the clinical characteristics of MSI-high (MSI-H) gastric cancer and the predictive value of MSI-H for adjuvant chemotherapy in large cohorts of gastric cancer patients were evaluated. Materials and Methods This study consisted of two cohorts. Cohort 1 included gastric cancer patients who received curative resection with pathologic stage IB-IIIC. Cohort 2 included patients with MSI-H gastric cancer who received curative resection with pathologic stage II/III. MSI was examined using two mononucleotide markers and three dinucleotide markers. Results Of 359 patients (cohort 1), 41 patients (11.4%) had MSI-H. MSI-H tumors were more frequently identified in older patients (p < 0.001), other histology than poorly cohesive, signet ring cell type (p=0.005), intestinal type (p=0.028), lower third tumor location (p=0.005), and absent perineural invasion (p=0.027). MSI-H status has a tendency of better disease-free survival (DFS) and overall survival (OS) in multivariable analyses (hazard ratio [HR], 0.4; p=0.059 and HR, 0.4; p=0.063, respectively). In the analysis of 162 MSI-H patients (cohort 2), adjuvant chemotherapy showed a significant benefit with respect to longer DFS and OS (p=0.047 and p=0.043, respectively). In multivariable analysis, adjuvant chemotherapy improved DFS (HR, 0.4; p=0.040). Conclusion MSI-H gastric cancer had distinct clinicopathologic findings. Even in MSI-H gastric cancer of retrospective cohort, adjuvant chemotherapy could show a survival benefit, which was in contrast to previous prospective studies and should be investigated in a further prospective trial.
김진원 慶星大學校 1992 論文集 Vol.13 No.2
Post-Occupany Evaluation is recognized and valued as a process that can improve, and help explain, the performance of the built environment. During the past twenty-five years it has emerged as a distinct area of research, scholary activity, and application, and work in the field has rapidly expanded-it now encompasses significant activity beyond that found in the standard environment-behavior literature. But, to date, in the field of PostOccupancy Evaluation there has been an apparent lack of coherent conceptual frameworks which are systematic, practice oriented, and which tie POEs to primary uses. This paper criticizes the concept of building performance evaluations and their elements, and it attempts to relate these to possible framework for improved evaluation research.
김진원 경성대학교 생산기술연구소 1997 생산기술연구지 Vol.4 No.-
A truly comprehensive assessment of environmental quality would include an appraisal of the quality of the experienced environment. Thus, observer-based evaluations of the every physical environment constitute an array of monitoring indices that could parallel complement the physically based system of indices now under development. The term index has usually been used in reference to an aggregation of individual indicators or measurements with collectively convey information about the quality of some complex aspects or component of condition, property, or phenomenon. If the perceived quality of various environmental components can be assessed with some precision, it may then be possible to begin to evaluate the components relative to others. Determining how much a given environmental components is worth cannot be approached until some method for assessing the component is available. Well-founded PEQIs can serve all of these important environmental design functions.