편측 뇌손상 환자의 동측 운동 결함에 대한 고찰

김중선,김경,권용현,Kim, Chung-Sun,Kim, Kyung,Kwon, Yong-Hyun 대한물리치료학회 2006 대한물리치료학회지 Vol.18 No.4

Recently, several investigations revealed that after unilateral brain damage, movement abnormalities were exposed on the ipsilateral side as well as the upper extremity contralateral to the damaged hemisphere. Even the motor abilities had significantly recovered from ipsilateral motor deficits on not only simple sensoriomotor function, also clinical assessments since subacute stage, although could not completely returned. Such motor deficits were detected in a diversity of motor tasks depending on the interhemispheric specialization, further in clinical evaluation and a daily of activities. In the clinical features, muscular weakness, sensory loss and impaired manual dexterity were observed. In a laboratory experiment, there were increasing evidences that the kinematic processing deficits was founded in various-specific motor tasks, which ranged from simple basic element to complex tasks, such as tapping task, step-tracking, goal directional aiming task, and iso(and non-)directional interlimb coordination. In the point of view, the manifest understanding in related to ipsilateral deficits provide the clinicians with an important information for scientific management about brain injured patient's prognosis and therapeutic guidelines.

경두개직류전류자극이 시열반응과제에 대한 운동 수행 능력에 미치는 영향

김중선,남석현,조인술,Kim, Chung-Sun,Nam, Seok-Hyun,Cho, In-Sul 대한물리치료학회 2010 대한물리치료학회지 Vol.22 No.5

Purpose: The aim of this study is to investigate whether motor cortex excitability by transcranial direct current stimulation (tDCS) over primary motor cortex (M1) affects motor performance of serial reaction task. Methods: Cathodal, anodal and sham tDCS (1 mA) are applied over right M1 of 24 subjects for 30 minutes including 11minutes for task period time. We applied two electrodes at the same position to both an experimental group and a sham-controlled group, and we made 2 groups recognize to be applicated of stimulation. Flexion, extension of wrist and thumb flexion are carried out following colors of arrows on the monitor. Serial reaction time task was applied to confirm the difference of the reaction time between 2 groups. Results: Reaction time is decreased in both tDCS-group and Sham-controlled tDCS group, and the degree of reduction is much greater in the post-test than pre-test. Reduction of reaction time between groupsis statistically significant. Conclusion: We consider that anodal tDCS increased the cortical excitability of the underlying motor cortex and it can be helpful to modulate motor performance. It seems that tDCS is an effective modality to modulate brain function, and it will be great help to mediate strategy for the brain injury patients.

Protective Effect of Administered Rolipram against Radiation-Induced Testicular Injury in Mice

김중선,Wan Lee,손영훈,Hyosun Jang,Min Ji Bae,Jungki Kim,Dongil Kang 대한남성과학회 2015 The World Journal of Men's Health Vol.33 No.1

Purpose: Pelvic irradiation for the treatment of cancer can affect normal cells, such as the rapidly proliferating spermatogenic cells of the testis, leading to infertility, a common post-irradiation problem. The present study investigated the radioprotective effect of rolipram, a specific phosphodiesterase type-IV inhibitor known to increase the expression and phosphorylation of the cyclic adenosine monophosphate response element-binding protein (CREB), a key factor for spermatogenesis, with the testicular system against pelvic irradiation.Materials and Methods: Male C57BL/6 mice were treated with pelvic irradiation (2 Gy) and rolipram, alone or in combination, and were sacrificed at 12 hours and 35 days after irradiation.Results: Rolipram protected germ cells from radiation-induced apoptosis at 12 hours after irradiation and significantly increased testis weight compared with irradiation controls at 35 days. Rolipram also ameliorated radiation-induced testicular morphological changes, such as changes in seminiferous tubular diameter and epithelial height. Additionally, seminiferous tubule repopulation and stem cell survival indices were higher in the rolipram-treated group than in the radiation group. Moreover, rolipram treatment counteracted the radiation-mediated decrease in the sperm count and mobility in the epididymis.Conclusions: These protective effects of rolipram treatment prior to irradiation may be mediated by the increase in pCREB levels at 12 hours post-irradiation and the attenuated decrease in pCREB levels in the testis at 35 days post-irradiation in the rolipram-treated group. These findings suggest that activation of CREB signaling by rolipram treatment ameliorates the detrimental effects of acute irradiation on testicular dysfunction and the related male reproductive functions in mice.

기능적 자기공명영상을 이용한 구심성 및 원심성 근 수축에 따른 뇌 활성도 분석

김중선,김중휘,박민규,박지원,Kim, Chung-Sun,Kim, Joong-Hwi,Park, Min-Kyu,Park, Ji-Won 대한물리치료학회 2010 대한물리치료학회지 Vol.22 No.2

Purpose: Behavior and movement are accomplished by voluntary contractions of skeletal muscles. There are three types of muscle contractions: concentric, isometric and eccentric. The aim of our study was to determine whether there is a difference in the cortical activation pattern between concentric contraction and eccentric contraction of the wrist extensor muscle. Methods: Four healthy right-handed volunteers without any previous history of physical or neurological illness were recruited. fMRI scanning was done during 4 repeated blocks of concentric and eccentric exercise of the wrist joint. Subjects exercised for 12 seconds and then rested for 12 seconds before beginning the second set of exercises. To determine the excitability of cortical neurons during exercise, voxel count and intensity index were analyzed. Results: For right hand movements, when concentric contractions of the right wrist were done, only the left primary motor area was activated. In contrast, during eccentric contraction, both the primary motor area and secondary motor area were activated. For left hand movements, both concentric and eccentric contractions induced only the supplementary motor cortex and the contralateral primary motor cortex. Conclusion: During eccentric contractions, both the primary motor area and secondary motor area are activated in ipsilateral and contralateral brain areas. Thus, eccentric contractions require more complex and difficult movements than concentric contractions do.

β-irradiation (166Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin

김중선,임경진,장원석,이선주,손영훈,이승숙,박선호,임상무 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1

In the present study, the detrimental effect of β-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing theanimals to 50 and 100 Gy of β-emission delivered by 166Ho patches. Clinicopathological and immunohistochemical changes in exposed skinwere monitored for 18 weeks after β-irradiation. Radiation induced desquamation at 2∼4 weeks and gradual repair of this damage was evident6 weeks after irradiation. Changes in basal cell density and skin depth corresponded to clinically relevant changes. Skin thickness began todecrease 1 week after irradiation, and the skin was thinnest 4 weeks after irradiation. Skin thickness increased transiently during recoveryfrom irradiation-induced skin injury, which was evident 6∼8 weeks after irradiation. Epidermal expression of nuclear factor-kappa B (NF-κB)differed significantly between the untreated and irradiated areas. One week after irradiation, cyclooxygenase-2 (COX-2) expression wasmostly limited to the basal cell layer and scattered among these cells. High levels of COX-2 expression were detected throughout the full depthof the skin 4 weeks after irradiation. These findings suggest that NF-κB and COX-2 play roles in epidermal cell regeneration followingβ-irradiation of mini-pig skin.

G-CSF increased thrombocytopenia by irradiation in mice and pigs

김중선,고창오,최문일,배민지,양광모 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.2

시각장애 아동과 정상 아동의 선자세 균형 비교

김중선,이정순,Kim Chung-sun,Lee Jeong-soon 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.1

In this paper, the proprioceptive sensitivity was compared by Foot-Hand task method and the effect of the proprioceptive sensitivity and auditory to the standing position between blind and normal children was measured using BPM for 56 children in 7, 8, 9 and 10 years old. There are three measurement methods are used for BPM : Rest, Forward Looking, 'Sound' position. The following conclusions were obtained from the above measurements. 1. In comparison of proprioceptive sensitivity between blind and normal children, there is no significant difference(p > .05). There is no significant difference in comparison of each age group and also there is no difference in each gender group(p > .05). 2. In comparison of standing position measurement between blind and normal children, there is any difference (p > .05) in three measurement(Rest, Forward Looking, 'Sound' position) but there is no significant difference in each gender difference(p > .05). There is any difference between Rest and 'Sound' position of blind children, also there is any difference between Forward Looking and ' Sound ' position, rest and 'Sound' position of normal children(p > .05). 3. There is no significant difference of correlation between proprioceptive sensitivity test and standing position measurement in Pearson correlation coefficient(p > .05).

Essentials of Primary Care : 순환기 (컨벤션홀 C) ; 비판막성 심방세동 환자에서 뇌졸중 예방을 위한 항응고 요법의 최신 Guideline

김중선 대한내과학회 2015 대한내과학회 춘계학술대회 Vol.2015 No.-

Sirolimus 용출성 스텐트(Cypher?) 시술 후 추적 혈관조영술 시발견된 스텐트 Strut 골절의 양상

김중선,윤영원,홍범기,권혁문,조정래,최대식,고영국,최동훈,장양수,김병극,오성진,전동운,양주영 대한심장학회 2006 Korean Circulation Journal Vol.36 No.6

뇌졸중 환자의 동측 경상 운동과 손상측 상지의 기능의 관계

김중선,권용현,장종성 대한작업치료학회 2008 대한작업치료학회지 Vol.16 No.1

목적 : 본 연구에서는 뇌졸중 환자에게 손상측 손의 주먹 쥐기 동작을 실시하여 동측 경상 운동 발현 유무를 확인하고, 동측 경상 운동과 손상측 상지 기능의 관계를 비교해 보고자 하였다. 연구방법 : 2개의 전자 악력계를 이용하여 손상측 손으로 대상자가 할 수 있는 최대의 힘으로 주먹 쥐기를 10초 동안 유지하는 것을 시행한 후 동측 경상 운동을 측정하고, 동측 경상 운동의 유무에 따라서 경상 운동이 나타나는 환자군 15명과 경상 운동이 나타나지 않는 환자군 15명으로 구분하였다. 경상 운동의 유무에 따른 손상측 상지의 기능을 비교하기 위해서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 측정을 실시하였다. 결과 : 동측 경상 운동이 나타나는 환자군과 경상 운동이 나타나지 않는 환자군의 집단 간의 손상측 상지 기능의 비교에서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 모두에서 통계학적으로 유의한 차이를 보였다(p<.05). 동측 경상 운동이 나타나는 환자군이 경상 운동이 나타나지 않는 환자군보다 상지의 전반적인 기능에서 좋지 않은 것으로 나타났다. 결론 : 뇌졸중 이후에 나타나는 동측 경상 운동은 상지 기능에 좋지 않은 영향을 미치는 것을 알 수 있고, 운동 결함이 있는 동측 경상 운동이 나타나는 환자에서 뇌졸중 이후 회복 과정의 임상적 양상을 알 수 있다. 따라서 뇌졸중 환자의 평가와 치료에 있어서 동측 경상 운동을 고려해야 하며, 앞으로 뇌졸중 환자에서 경상 운동의 지속적인 평가와 치료적 중재에 관한 연구가 필요할 것이다. Objective : Ipsilateral mirror movements (MMs) are involuntary movements of one limb during voluntary unilateral movements of the opposite limb. MM decreases in the course of motor development, but may reappear in adults suffering from brain damage after a stroke. The purpose of this study is to measure MM and compare the relationship between ipsilateral MM and the motor function of the affected upper extremity in stroke patients. Methods : Fifteen stroke patients with MM and fifteen stroke patients without MM were selected for this study. Two dynamometers were used during a squeezing task in order to measure the intended movements from the active hand as well as MM from the opposite hand. The upper extremity's motor function was measured using Fugl-Meyer Assesment (FMA), Purdue Pegboard Test (Purdue), and grip strength. Results : There was a significant difference in the upper extremity's motor function according to FMA, Purdue, and grip strength, depending on the presence of MM. The motor deficit of patients with MM was significantly greater than that of patients without MM. Conclusion : The findings show that stroke patients with MM have a significant motor deficit. The observation of ipsilateral hand MMs with greater motor deficit may suggest that these MMs represent a clinical sign of the restorative processes after a stroke. Therefore, the evaluation of MM can be useful for the assessment and treatment of stroke patients. Further studies are needed to attempt temporal assessments and develop a treatment intervention of MM after a stroke