Watersheds 기반 계층적 이진화를 이용한 단백질 반점 분할 알고리즘

김영호,김정자,김대현,원용관,Kim Youngho,Kim JungJa,Kim Daehyun,Won Yonggwan 한국정보처리학회 2005 정보처리학회논문지B Vol.12 No.3

생물학자가 단백질을 검색하고 분석하기 위해서는 2차원 젤 전기영동(2DGE : Two Dimensional Gel Electrophoresis) 실험을 해야 한다. 실험 결과는 2차원 영상이 생성된다. 2차원 영상에서 단백질 반점의 패턴 분석을 위해 2차원 젤 영상에 펼쳐진 단백질 반점들을 영상처리를 통해 분할하고, 대조 그룹의 단백질 패턴과 비교분석을 통해 밝히고자하는 단백질 반점을 찾아내야 한다. 단백질 반점을 분할하는 알고리즘에 있어서 기존에는 가우시안 함수를 적용하였지만, 최근 들어 형태학 분리개념에 의한 Watersheds 영역기반 분할(Watersheds region-based segmentation) 알고리즘을 활용하고 있다. 그러나 Watersheds 영역기반 분할 알고리즘은 크기가 큰 영상에서 원하는 영역을 신속하게 분할한다는 장점이 있지만, 영상 화소의 그레이 값이 연속적인 경우 실제 반점의 개수 에 비해 과다분할(over-segmentation)되거나 과소분할(under-segmentation)의 문제점을 안고 있다. 이는 마커(marker) 포인트의 설정에 의해 어느 정도 해결할 수 있지만 병합(merge)과 분할(split) 과정을 반복해야 한다. 본 논문은 Watersheds 기반 계층적 이진화 기법을 적용하여 마커 드리븐 Watersheds 영상분할의 문제점을 해결하고자 한다. Biologist must have to do 2DGE biological experiment for Protein Search and Analysis. This experiment coming into being 2 dimensional image. 2DGE (2D Gel Electrophoresis : two dimensional gel electrophoresis) image is the most widely used method for isolating of the objective protein by comparative analysis of the protein spot pattern in the gel plane. The process of protein spot analysis, firstly segment protein spots that are spread in 2D gel plane by image processing and can find important protein spots through comparative analysis with protein pattern of contrast group. In the algorithm which detect protein spots, previous 2DGE image analysis is applies gaussian fitting, however recently Watersheds region based segmentation algorithm, which is based on morphological segmentation is applied. Watersheds has the benefit that segment rapidly needed field in big sized image, however has under-segmentation and over-segmentation of spot area when gray level is continuous. The drawback was somewhat solved by marker point institution, but needs the split and merge process. This paper introduces a novel marker search of protein spots by watersheds-based hierarchical threshold, which can resolve the problem of marker-driven watersheds.

기관지내 발생한 과오종치험 1례

김영호,김수성,김공수,Kim, Yeong-Ho,Kim, Su-Seong,Kim, Gong-Su 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.1

The origin of hamartoma from the Greek words for "error" and "tumor" is credited to Albrecht who in 1904 described a disorganized arrangement of tissues normally present in an organ and applied also to tumors found in many organs other than the lung. The hamartoma is the most common benign tumor of the lung and revealed accidentally as asymptomatic coin lesion on routine chest X-ray, but the incidence is very low and especially endobronchial origin extremely low. We have been successful surgical experienced one case of a 36-year-old female having endobronchial hamartoma, 4x2.Sx2 cm in size and located at right main bronchial lumen near the carina, which consists of a hard, nodular surfaced mass and adhered to the cartilaginous portion of the right upper lobe bronchus by dense fibrous band and migrate to trachea on expiration or coughing. This case was not suspected by chest X-ray or bronchogram and confirmed bronchoscopy with biopsy. Right pneumonectomy was inevitable because of bronchiectatic change of right bronchus due to tumor obstruction. She was discharged with relatively good general condition on 21 days postoperatively.

팽이버섯 분열자의 생성원인 및 특성

김영호,공원식,김경수,유창현,김한경,성재모,류영진,김광호 ( Young Ho Kim,Won Sik Kong,Kyung Soo Kim,Chang Hyun You,Han Kyoung Kim,Jae Mo Sung,Young Jin Ryu,Kwang Ho Kim ) 한국균학회 1998 韓國菌學會誌 Vol.26 No.2

Treadmill에서의 경사로 정상보행에 관한 동작분석

김영호,양길태,문무성,Kim, Youngho,Yang, Giltae,Mun, Museong 대한의용생체공학회 1997 의공학회지 Vol.18 No.1

Kinematic and kinetic studies were performed to investigate the walking characteristics on a treadmill with various slopes at the same speed of 1.25m/sec. Six different slopes of the treadmill were selected . -4%(-$2.3^{\circ}$), 0%($0^{\circ}$), 5%($2.9^{\circ}$), 10%($5.7^{\circ}$), 15%($8.6^{\circ}$), and 20%($11.3^{\circ}$). With increased slopes of the treadmill, both hip and knee flexion angles significantly increased at initial contact, and the maximum hip flexion during swing phase and the maximum knee flexion during stance phase also significantly increased Ankle dorsiflexion angle at initial contact and the maximum dorsiflexion increased with increased slopes. However, the maximum plantarflexion in early swing was slightly reduced with increased slopes. Hip extension in late stance and the maximum knee flexion in early swing was not changed sigilificantly with increased slopes. As for the vertical ground reaction force, compared to the yond level walking, both the first and the second peak forces increased, but the mid-support force decreased.

다카키 겐이치 지음 "전후보상의 논리"

김영호,Kim, Yeong-Ho 대한출판문화협회 1995 출판저널 Vol.174 No.-

정신대.피폭자문제 등에 깊이 관여해온 국제인권변호사 다카키 겐이치의 "전후보상의 논리"는 전후보상문제에 앞장서 실천한 경험을 토대로 이론적 탐색을 시도하고 있다. 저자는 '전후보상'이란 민사적인 피해회복을 위한 피할 수 없는 역사의 과제임을 언급하고 아시아 각국의 전후보상 요구의 움직임을 생생히 들려주고 있다.

N-methyloldimethylphosphonopropionamide를 사용한 면직물의 방염가공시 질소화합물이 처리 직물의 방염성과 강도 변화에 미치는 영향

김영호,김갑진,Kim, Yeong-Ho,Kim, Gap-Jin 한국섬유공학회 1996 한국섬유공학회지 Vol.33 No.11

Flame retardant finish of cotton fabrics was carried out using N-methyloldimethylphosphonopropionamide(MDPPA) in conjunction with nitrogen compounds such as hexamethylolmelamine(HMM) and dimnethyloldimethoxyethylene urea(DMDMEU). The effects of nitrogen compounds on the flame retardancy and strength retention(tensile and tearing) of the treated fabrics before and after laundering were investigated. The results obtained are as follows; Flame retardancy increased with the concentration of MDPPA. Durable flame retardancy after 50 laundry cycles could be obtained when MDPPA concentration was more than 40%. Nitrogen compounds used with MDPPA enhanced flame retardency and durability to laundering. Among the three types of nitrogen compounds, i.e., HMM, DMDMEU, and HMM/DMDMEU(1/1) mixture, mixture of HMM/DMDMEU(1/1) was most effective to enhance flame retardency and durability. Tensile strength retention of treated fabric increased slightly with the amount of nitrogen compound. But tearing strength retention was not significantly affected by the types and the amount of nitrogen compound.

Puromycin Aminonucleoside 투여로 인한 사구체 족세포의 초미형태학적 변화

김영호,박관규,김영만,조수열,Kim, Young-Ho,Park, Kwan-Kyu,Kim, Young-Man,Cho, Soo-Yeul 한국현미경학회 1998 Applied microscopy Vol.28 No.4

Puromycin aminonucleoside (PAN) nephropathy was induced in a group of Sprague-Dawley rat by a single dose of intraperitoneal Injection to study an ultrastructural change of glomerulus. The experimental rats developed proteinuria three days after PAN injection. Electron microscopic studies of glomeruli showed the loss of epithelial foot processes, formation of cytoplasmic vacuoles, microvillous formation and increased numbers of lysosomes in the cytoplasm of podocytes. It is strongly suggested that proteinuria in PAN nephrosis may be primarily due to a glomerular epithelial lesion, leading to focal disarray of anionic sites or focal defects in the epithelial covering of the basement membrane. The loss of anionic sites in the basement membrane nay be caused by the foot process fusion and the epithelial detachment from the basement membrane.

협설만곡치아의 파노라마방사선영상소견에 대한 연구

김영호,정환석,허경회,이원진,허민석,이삼선,최순철,Kim, Young-Ho,Jeong, Hwan-Seok,Huh, Kyung-Hoe,Yi, Won-Jin,Heo, Min-Suk,Lee, Sam-Sun,Choi, Soon-Chul 대한영상치의학회 2010 Imaging Science in Dentistry Vol.40 No.1

Purpose : We want to identify the appearance of the buccolingual root dilaceration teeth in the panoramic views and specify the characteristics of these teeth. Materials and Methods : One thousand-six patients were examined on the basis of both panoramic and CT image criteria. We diagnosed and excluded certain teeth from the samples; both prosthodontic or pathologic lesion appearing teeth and mesiodistally dilacerated ones. We meticulously discerned buccolingually dilacerated teeth in the CT images and total 48 samples were selected. The degree of severity in dilaceration was standardized by 2 types of criteria. The samples were differentiated into 3 groups and again categorized into six types showing from the panoramic views: irregular view on the root apex area, clear blunt on the root tip, stepping on root tip, double lamina dura or double tip, arrow-target shaped root, bull's eye, normal view. Results : The types of teeth selected from total 48 buccolingual root dilaceration samples were mandibular first and second molar, premolars, canines, and lateral incisors. The direction of dilaceration was an even percentage to each buccal and lingual side for most selected teeth, however, that of both canines and lateral incisors were directed in almost a buccal side. In the panoramic views, the root types of the buccolingually dilacerated teeth were irregular view on the root apex area, clear blunt on the root tip, stepping on root tip and normal types were almost always normal view. The more severity in dilareated degree, the more chances of observation in the panoramic views were clear blunt on the root tip and stepping on root tip. Conclusion : As observed in the shape of stepping on root tip or double lamina dura in the panoramic views, there can be much more probability to diagnose as a buccolingually dilacerated root.

배관계통의 내구성에 대하여

김영호,Kim, Yeong-Ho 한국설비기술협회 1996 설비 : 공조ㆍ냉동ㆍ위생 Vol.13 No.5

출판저널 칼럼

김영호,Kim, Yeong-Ho 대한출판문화협회 1995 출판저널 Vol.167 No.-