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인삼의 Petroleum Ether 추출액의 흰쥐 방광암 유발억제효과
김순찬,고성건 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.1
It has been proven that Panax ginseng root has inhibitory effect on carcinogenesis of some tumors. This study is intended to observe the inhibitory effect of petroleum ether extract of Panax ginseng root on carcinogenesis of rat vesical tumor induced by N-butyl -N(4-hydroxybutyl) -nitrosamine(BBN). As experimental animal, 100 female Wistar rats were used, and these were divided into 2 groups according to their duration of study. The duration of experiment was for 12 weeks in group Ⅰ, 18 weeks in group Ⅱ . Each group was divided into 4 subgroups(A, B, C, and D). Group Ⅰ-A was fed with normal diet and normal drinking water as control group, while group Ⅰ-B with normal diet and carcinogenic drinking water of 0.05% BBN solution, group Ⅰ-C with petroleum ether extract of Panax ginseng root added to normal diet and normal drinking water, and group Ⅰ-D with petroleum ether extract of Panax ginseng root added to normal diet and carcinogenic drinking water of 0.05 % BBN solution. Likewise group Ⅱ-A was fed with normal diet and normal drinking water as control group and group Ⅱ-C was fed with petroleum ether extract of Panax ginseng root added to normal diet and normal drinking water, However, group Ⅱ -B and group Ⅱ -D were given carcinogenic drinking water of 0.05% BBN solution for 12 weeks and thereafter normal water for 6 weeks. Group Ⅱ -B was fed with normal diet while group Ⅱ-D with petroleum ether extract of Panax ginseng root added to normal diet for 18 weeks respectively. The histopathological changes of the rat bladder observed were as follows: 1. In group Ⅰ the subgroup which given petroleum ether extract of Panax ginseng root did not significantly suppress the development of hyperplasia, papilloma, dysplasia( CIS) and transitional cell carcinoma on the rat vesical epithelium but statistically significantly suppress the development of squamous metaplasia. 2. in group Ⅱ the subgroup which given petroleum ether extract of Panax ginseng root did not significantly suppress the development of hyperplasia, papilloma, dysplasia( CIS) and transitional cell carcinoma but significantly suppress the development of squamous metaplasia and squamous cel carcinoma. 3. From the viewpoint of grade and histopathological multiplicity of transitional cell carcinoma in group Ⅱ, there was no difference between group Ⅱ -B and group Ⅱ -D. 4. In invasiveness, all the developed carcinoma showed superficial involvement.
맹주은,김순찬,송명현,정나현,구자록,Ju Eun Maeng,Soon-Chan Kim,Myoung-Hyun Song,Nahyun Jeong,Ja-Lok Ku 대한소화기암연구학회 2022 Journal of digestive cancer reports Vol.10 No.2
Gastrointestinal cancer accounts for one-third of the overall cancer occurrence worldwide. Pancreatic ductal adenocarcinoma (PDAC) is a type of gastrointestinal cancer that is known to be one of the most fatal among all cancer types, with a 5-year survival rate of less than 8%. Chemotherapy combined with surgical resection is its probable curative option. However, surgery is accessible for only 10-15% of patients diagnosed with PDAC. Organoids show self-organizing capacities and resemble the original tissue in terms of morphology and function. Organoids can also be cultured with high effectiveness from tumor tissues derived from each patient, making them an extremely fitting model for translational uses and improving personalized cancer medicine. Enhancing drug screening platforms is necessary to apply personalized medicinebased organoids in clinical settings.
농어촌 의료취약지역에서의 고혈압관리 실태와 보건진료전담공무원의 역할
조수연,김순찬,유정임,한종숙,서가원,Cho, Sooyeoun,Kim, Soonchan,Ryu, Jeougim,Han, Jongsuk,Seo, Kawoun 한국농촌간호학회 2018 한국농촌간호학회지 Vol.13 No.2
Purpose: This study was a descriptive study to investigate correlations between self-care behaviors and quality of hypertension management by hypertensive patients being cared by community health practitioners. Method: Participants were 583 people who were prescribed antihypertensive medications at a health clinic located in South Chungcheong Province. The survey was done from June 1 to July 30, 2018. A self-report questionnaire was administered, and data analysis was performed using descriptive statistics and Pearson correlation coefficients with the SPSS 24.0 program. Results: The rate of awareness, treatment, and control of hypertension were 97.9%, 99.1% and 92.8%, respectively. The number of hypertensive self-care behaviors was 1.82 (${\pm}0.36$) out of 3 points. The quality of hypertension management was 3.22 (${\pm}0.46$) out of 4 points. There was a moderate correlation between hypertensive self-care behaviors and quality of hypertension management (r=.340, p<.001). Conclusions: Results of this study confirm that the quality of hypertension management by community health practitioners is related to self-care behaviors of hypertensive patients. Therefore, it is necessary to improve the quality of hypertension management by health care specialists for self-management of hypertension patients. In addition, a systematic program to improve the quality of hypertension management by community health practitioner is needed.