전전치태반이 합병된 임신에서 모성 및 주산기 예후

김금재 ( Keum Jae Kim ),구자남 ( Ja Nam Koo ),원혜성 ( Hye Sung Won ),유혜경 ( Hye Kyung Yoo ),이필량 ( Pil Ryang Lee ),이인식 ( In Sik Lee ),전대준 ( Dae Joon Jeon ),김암 ( Ahm Kim ),남주현 ( Joo Hyun Nam ) 대한주산의학회 1998 大韓周産醫學會雜誌 Vol.9 No.4

태아간 체중 차이가 큰 쌍태 임신의 주산기 예후

김금재(Keum Jae Kim),김미경(Mi Kyung Kim),유혜경(Hye Kyung Yoo),오혜은(Hye Eun Oh),원혜성(Hye Sung Won),이필량(Pil Ryang Lee),이인식(In Sik Lee),김암(Ahm Kim),남주현(Joo Hyun Nam) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9

목적: 체중 불일치가 불량한 주산기 예후의 위험 예측 인자가 되는지 알아 보고자 하였다. 연구 방법: 출생시 임신 주수가 28주 이상이었던 쌍태 임신 375 예를 연구 대상으로 하여 산모와 신생아의 의무기록을 검토하는 후향적 연구를 시행하였다. 연구 대상은 쌍태아간 체중 불일치 정도에 따라 2 군으로 분류하였다.(I 군: 25% 미만, II 군:25% 이상) 쌍태아간 체중 불일치의 정도는 (큰 쌍태아의 체중 - 작은 쌍태아의 체중)/큰 쌍태아의 체중 x 100(%) 으로 계산하였다. 2 군간의 주산기 및 신생아 예후를 비교하였으며 II 군에서는 체중이 큰 신생아와 작은 신생아를 서로 비교하였다. 체중 불일치가 불량한 주산기 예후의 독립 변수가 될 수 있는지를 알아보기 위하여 다변량 분석이 시행되었다. 결과: 37 예의 쌍태 임신이 II 군으로 분류 되었으며 II 군은 의미있게 전자간증, 전치 태반 그리고 저출생 체중아의 발생 빈도가 높았다.(각각 p<0.01, p<0.05, p<0.001) 신생아 호흡부전 증후군, 폐렴, 기관지폐 이형성증, 동맥관 개존증, 뇌실내 출혈, 조산아 망막병증, 괴사성 장염, 패혈증 및 선천성 기형의 빈도와 신생아 사망률이 p<0.01로 II군에서 유의하게 증가한 소견을 보였다. II 군중에서 체중이 큰 신생아와 작은 신생아의 비교에서는 저출생 체중아의 발생 빈도(p<0.005)를 제외하고는 의미 있게 다른 결과는 없었다. 그러나 체중 불일치는 불량한 주산기 에후를 예측하는 독립 변수는 아닌 것으로 나타났다. 결론: 25 % 이상의 체중 불일치는 쌍태 임신에서 불량한 주산기 예후의 위험 인자로 여겨져 왔다. 그러나 태아 체중 불일치의 소견 그 자체가 독립적으로 임신 예후를 결정해 주는 것은 아니라고 판단된다. Objective: To evaluate whether twin discordancy is a risk factor for adverse perinatal and neonatal outcomes. Methods: Three hundred and seventy-five twin gestations over 28 weeks of gestation were included in this retrospective study. Medical records of mothers and infants were reviewed. Pregnancies were divided into 2 groups according to the birth weight discordancy(%) between twin neonates(group I;less than 25%, group II;25% or more). Birth weight discordancy was calculated from following formula; (birth weight of larger twin-birth weight of smaller twin)/ birth weight of larger twin x 100. Perinatal and neonatal outcomes in group I and II were compared with each other. Also, difference in the outcomes between the smaller and larger twins of group II was evaluated. To evaluate whether birth weight discordancy is an independent variable in predicting poor perinatal and neonatal outcomes, multiple logistic regression analysis was used. Results: Thirty-seven gestations(9.9%) were documented to belong to group II. Group II showed significantly higher incidence of preeclampsia, placenta previa, and small for gestational age infants(p<0.01, p<0.05 and p<0.001, respectively). The group also showed higher incidence of adverse neonatal outcomes(admission to neonatal intensive care unit, respiratory distress syndrome, pneumonia, bronchopulmonary dysplasia, patent ductus arteriosus, intraventricular hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, sepsis, congenital anomaly, neonatal death, p<0.01). Outcomes of the larger and smaller twins of group II were not significantly different with each other except small for gestational age infants(p<0.005). However, birth weight discordancy was not an independent variable in predicting adverse perinatal and neonatal outcomes. Conclusion: Fetal growth discordancy of 25% or more should be regarded as a risk factor for adverse perinatal and neonatal outcomes in twin gestations. However it is not an independent factor in predicting adverse perinatal and neonatal outcomes.

에타놀투여가 마우스의 면역반응에 미치는 영향에 관한 실험적 연구

김금재(Kim, Keum Jae) 한국간호과학회 1991 Journal of Korean Academy of Nursing Vol.21 No.1

甲狀線疾患(湖南地方)과 그 診斷 및 治療中 放射性 洞位元素 取扱에 關한 看護上의 硏究

金錦才 최신의학사 1974 最新醫學 Vol.17 No.7

848 patients with diseases of the thyroid gland were surveyed through clinical- observation and investigated about nursing problems in the course of diagnosis and treatment of thyroid disease with 1131 (I^(131) radioisotope) at the radioisotope clinic of Cheonnam National University Hospital for the last 9 years from Jan. 1962 to Dec. 1970. Results are as follows: 1. The ratio between male and female is 1:5,5. 2. Age distribution shows' that the number of female patients are highest in the third decade and lowest in the sixth decade, but the highest incidence of males is in the fourth decade and-.lowest in the sixth decade. 3. The distance between patient and nurse and the duration of treatment are' very important points during the exposure to I^(131) Radioisotope. This should be kept in mind to avoid contamination especially by RI-I^(131) contaminated urine. 4. The maximum external exposure amount in the course of treatment and diagnosis of thyroid disease with radioisotope is less than one fourth (1/4) of the recommended amount by ICRP. 5. Serial hematologic examinations were checked up every three months. and the results were within normal limits. 6. We have reviewed six points to be kept in mind by a nurse while handling radioisotope.

한국산 식용버섯의 지방질 성분에 관한 연구

김태영,김영희,홍재식,김명곤,김금재 한국식생활문화학회 1990 韓國食生活文化學會誌 Vol.5 No.4

국내에서 생산되는 재배버섯으로 일반느타리(Pleurotus ostreatus)와 고온성느타리(Pleurotus sajor-caju) 및 야생식용버섯으로 싸리버섯(Ramaria botrytis)과 젖버섯(Lactarius volemus)의 지질성분조성을 비교 검토한 결과 각 버섯의 지방함량은 0.32∼0.39%이었으며, 그 조성은 인지질(19.4∼47.4%), 중성지질(32.1∼51.9%), 당지질(14.8∼28.7%) 순으로 많았으나 고온성 느타리는 다른 버섯에 비하여 중성지질(51.9%)의 함량이 높았다. 중성지질에서는 triglyceride(21.2∼38.2%), free sterol(21.0∼21.9%), sterol ester(10.3∼18.6%) 순으로 많았으나 고온성 느타리는 free fatty acid(34.1%)의 함량이 다른 버섯에 비하여 특이하게 높았다. 당지질은 steryl glycoside(15.6∼29.4%), esterified steryl glycoside(13.4∼23.9%), monogalactosyl diglyceride(15.6∼24.6%) 순으로 많았으며, 인지질의 조성은 phosphatidyl choline(36.7∼49.5%), phosphatidyl ethanolamine(20.9∼29.7%), phosphatidyl inositol(18.4∼26.1%) 순으로 많았다. 각 구성지질의 지방산조성은 4종의 버섯 공히 linoleic acid와 palmitic acid가 주요 지방산이었으나 싸리버섯은 중성지질에서 oleic acid의 함량이 높았다. Three fractions-neutral lipids, glycolipids and phospholipids were obtained from total lipids in cultivated mushrooms(Pleurotus ostreatus and Pleurotus sajor-caju) and wild mushrooms (Ramaria botrytis and Lactarius volemus), and their lipid compositions and fatty acid compositions were determined by means of silicic acid column chromatography, thin layer chromatography and gas liquid chromatography. The total lipid contents in mushrooms were 0.32∼0.39%(wet basis). It was found that the contents of phospholipids(19.4∼47.4%) and neutral lipids(32.1∼51.9%) were high, while that of glycolipids(14.8∼28.7%) were low. The main lipid in neutral lipids was triglyceride(21.2∼38.2%) followed by free sterol(21.0∼21.9%), sterol ester(10.3∼18.6%), but the main lipid in neutral lipid of Pleurotus sajor-caju was free fatty acid(34.1%). The main lipid in glycolipids was steryl glycoside(15.6∼29.4%) followed by esterified steryl glycoside(13.4∼23.9%), monogalactosyl diglyceride(15.6∼24.6%). Among the phospholipids, phosphatidyl choline(36.7∼49.5%), phosphatidyl ethanolamine(20.9∼29.7%), phosphatidyl inositol(18.4∼26.1%) were the major components. The major fatty acid of total lipids was linoleic acid followed by palmitic acid, oleic acid. Fatty acid composition was not significantly different among total lipids, neutral lipids, glycolipids and phospholipids contained in tested mushrooms but the main fatty acid in neutral lipid of Ramaria botrytis was oleic acid(48.7%).

Lenzites betulina에 의한 Tannase 생산 및 성질에 관한 연구

홍재식,김명곤,윤숙,김금재,곽인구 한국산업미생물학회 1990 한국미생물·생명공학회지 Vol.18 No.6

Lenzites betulina(조개껍질버섯균) 등 6종 담자균류의 tannase(tannin acyl hydrolase EC 3.1, 1.20) 생산을 비교하고 Lenzites betulina가 가장 우수하여 이 균주의 배양물로부터 효과적인 tannase 생산조건과 효소의 특성을 검토하였다. Lenzites betulina의 tannase 최적 생산을 위한 배양조건은 25℃, pH6.0에서 21일이었고, tannase 생산을 위한 효과적인 배양기질의 조성은 tannic acid 2g, sucrose 5g, bacto-peptone 2g, KH_PO_4 2g, MgSO_4·7H_2O 0.05g, CuSO_4·5H_2O 2㎎, thiamine·HCl 100㎍, 증류수 1000㎖이었다. 이상의 조건에서 Lenzites betulina가 생산하는 tannase는 223.3unit(gallic acid umole/㎖/min)이었다. Lenzites betulina가 생산하는 tannase의 반응 최적 pH는 6.0, 최적 온도는 40℃이었고, 40℃ 이하에서는 효소활성이 대단히 안정하였으나 60℃ 이상에서는 50% 이상 실활하여 고온에 민감하였다. 또한, pH5.5-6.0의 범위에서는 비교적 안정을 유지하였다. Six species under the basidiomycetes were screened for extracellular tannase(tannin acyl hydrolase EC 3.1, 1.20) production in submerged culture and Lenzites betulina was found to be most effective for the production of tannase. The optimum cultural conditions for tannase production were 25℃, pH 6.0 and 21 days of culture period. The efficient composition of culture medium for the production of tannase was performed in synthetic medium containing tannic acid, 2g; sucrose, 5g; bacto-peptone, 2g; KH_2HO_4, 2g; MgSO·7H_2O, 0.5g; CuSO_4·5H_2O, 2㎎; thiamine HCl, 100 ug and distilled water 100 ㎖. The tannase produced from Lenzites betulina was 223.3 unit(umole of gallic acid/㎖ of broth/min). The tannase had an optimal reaction conditions of pH 6.0 and temperature of 40℃. The enzyme was stable at temperature below 40℃ and lost its activity by 50% above 60℃. And the stable pH range was 5.5 to 6.0.