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거대세포 바이러스 간염이 동반된 장성 선단 피부염 1례
김광렬,박재옥,신상만,Kim, Kwang-Yeol,Park, Jae-Ock,Shin, Sang-Mann 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2
Acrodermatitis enteropethica (AE) is a rare autosomal recessive disorder of zinc absorption leading to chronic diarrhea and characteristic skin lesion. The term is also applied to any acquired zinc deficiency state resulting in the same clinical pictures. We experienced one case of AE in 1 month old male infant who had bacterial enterocolitis. The skin around mouth, anus, eyes, ears, hands and legs became reddish, vesicular and eczematoid. Serum zinc level was decreased to $51.4\;{\mu}g/dL$ (N=70~150). Endoscopic finding revealed pale gastric mucosa and villous atrophy of small intestine. Biopsy finding of small intestine showed no villi due to mucosal atrophy. On 13 day of admission jaundice with DIC were noted and AST & ALT were elevated to 110 & 36.8 IU/L, respectively. Diarrhea was improved but jaundice and liver function were not recovered until discharge from hospital. After discharge when the patient was 4 months of age serum bilirubin and AST/ALT had not been normalized. CMV shell vial culture of urine and CMV Ig G antibody were positive. So intravenous ganciclovir injection of 7.5 mg/kg, two times a day for 2 weeks and then 10 mg/kg/day for 3 months was done from 4 to 6 months of age. No virus was found in the urine and AST & ALT were normalized at 2 months after stopping ganciclovir treatment.
Surgical Strategy for Sacral Tumor Resection
김광렬,김경현,박정윤,신동아,하윤,김긍년,진동규,김근수,조용은,구성욱 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1
Purpose: This study aimed to present our experiences with a precise surgical strategy for sacrectomy. Materials and Methods: This study comprised a retrospective review of 16 patients (6 males and 10 females) who underwent sacrectomyfrom 2011 to 2019. The average age was 42.4 years old, and the mean follow-up period was 40.8 months. Clinical data,including age, sex, history, pathology, radiographs, surgical approaches, onset of recurrence, and prognosis, were analyzed. Results: The main preoperative symptom was non-specific local pain. Nine patients (56%) complained of bladder and bowelsymptoms. All patients required spinopelvic reconstruction after sacrectomy. Three patients, one high, one middle, and one hemisacrectomy,underwent spinopelvic reconstruction. The pathology findings of tumors varied (chordoma, n=7; nerve sheath tumor,n=4; giant cell tumor, n=3, etc.). Adjuvant radiotherapy was performed for 5 patients, chemotherapy for three, and combinedchemoradiotherapy for another three. Six patients (38%) reported postoperative motor weakness, and newly postoperative bladderand bowel symptoms occurred in 5 patients. Three patients (12%) experienced recurrence and expired. Conclusion: In surgical resection of sacral tumors, the surgical approach depends on the size, location, extension, and pathologyof the tumors. The recommended treatment option for sacral tumors is to remove as much of the tumor as possible. The level ofroot sacrifice is a predicting factor for postoperative neurologic functional impairment and the potential for morbidity. Pre-operativeangiography and embolization are recommended to prevent excessive bleeding during surgery. Spinopelvic reconstructionmust be considered following a total or high sacrectomy or sacroiliac joint removal.
김광렬,강주희,김철우,남문석 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.2
The simultaneous, quantitative and rapid analysis of plasma concentrations of multiple drugs is important to determine the clinical decision and to expect the prognosis in patients administered in emergency unit with intoxication. Here, we developed the liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based drug screening method for analyzing 12 drugs (acetaminophen, amitriptyline, chlorpromazine,cimetidine, diazepam, doxylamine, ephedrine, imipramine, metoclopramide, propranolol, tramadol, and zolpidem) with frequent events of intoxication throughout the country and evaluated its clinical applicability. The overall sensitivity (low limit of quantitation, 0.1-0.5 μg/mL), specificity, precision and accuracy for the quantification of 12 drugs were reliable and all drugs can be analyzed within 6 min. Among 12 drugs in samples for quality control, the REMEDi HS-based method detected only 6 drugs with low accuracy, while the LC-MS/MS system was able to precisely quantify all drugs. In addition, pilot analysis of patient samples with unknown drug intoxication was superior to the conventional LC-based drug profiling system, and was rapid and cost effective. In conclusion, LC-MS/MS-based drug screening is a good replacement for conventional LC-based REMEDi analyzer and has the better clinical applicability.
김광렬,Kim, Kwang-Roul 한국가구학회 2005 한국가구학회지 Vol.16 No.2
The approach for designing Church furniture has to be different from that of mass production. church furniture has to be harmonized with an interior space and a church building. Since each church has different pursues and emphases on doctrines, a designer must understand the contents of Holly Bible and uses them as symbolic images. This study analyzes the characteristics and the meanings of patterns and colors in church furniture in general, which embraced to a design direction. There are two different situations on a death in Holy Bible which is the Resurrection and the Gate in heaven that would enter after a death. In this study, based on these two as sources of inspiration, furniture design emphasizes aesthetical uses of sources and Korean images. With technical drawings, scaled models, and prototypes, this study searches for a new direction for Korean church furniture and suggests a distinctive church space.