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김광렬,남문석,권현정,김광현,강승현,김상일,김철우,조상헌 대한임상약리학회 2017 Translational and Clinical Pharmacology Vol.25 No.1
A simple, rapid, and reliable UPLC-MS/MS method was developed and validated for the determinationof tadalafil in human plasma. The plasma samples were deproteinized with acetonitrile. Chromatographicseparation was performed on a Shiseido C18 (100 × 2.1 mm, 2.7 μm) column withisocratic elution using 2.0 mM ammonium acetate and acetonitrile (55:45, v/v) with 0.1% formicacid at a flow rate of 0.7 mL/min. The total run time was 1 min per sample. The quantitative analysiswas performed using multiple reaction monitoring at transition of m/z 390.4 → 268.3 for tadalafiland m/z 475.3 → 283.3 for sildenafil as an internal standard. The method was fully validated overa concentration range of 5–1,000 ng/mL with a lower quantification limit of 5 ng/mL. Intra- andinter-day precision (relative standard deviation, %RSD) were within 8.4% and accuracy (relative error,%RE) was lower than -3.2%. The developed and validated method was successfully applied to apharmacokinetic study of tadalafil (20 mg) in Korean healthy male subjects (n = 12).
거대세포 바이러스 간염이 동반된 장성 선단 피부염 1례
김광렬,박재옥,신상만,Kim, Kwang-Yeol,Park, Jae-Ock,Shin, Sang-Mann 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2
Acrodermatitis enteropethica (AE) is a rare autosomal recessive disorder of zinc absorption leading to chronic diarrhea and characteristic skin lesion. The term is also applied to any acquired zinc deficiency state resulting in the same clinical pictures. We experienced one case of AE in 1 month old male infant who had bacterial enterocolitis. The skin around mouth, anus, eyes, ears, hands and legs became reddish, vesicular and eczematoid. Serum zinc level was decreased to $51.4\;{\mu}g/dL$ (N=70~150). Endoscopic finding revealed pale gastric mucosa and villous atrophy of small intestine. Biopsy finding of small intestine showed no villi due to mucosal atrophy. On 13 day of admission jaundice with DIC were noted and AST & ALT were elevated to 110 & 36.8 IU/L, respectively. Diarrhea was improved but jaundice and liver function were not recovered until discharge from hospital. After discharge when the patient was 4 months of age serum bilirubin and AST/ALT had not been normalized. CMV shell vial culture of urine and CMV Ig G antibody were positive. So intravenous ganciclovir injection of 7.5 mg/kg, two times a day for 2 weeks and then 10 mg/kg/day for 3 months was done from 4 to 6 months of age. No virus was found in the urine and AST & ALT were normalized at 2 months after stopping ganciclovir treatment.
김광렬,강주희,김철우,남문석 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.2
The simultaneous, quantitative and rapid analysis of plasma concentrations of multiple drugs is important to determine the clinical decision and to expect the prognosis in patients administered in emergency unit with intoxication. Here, we developed the liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based drug screening method for analyzing 12 drugs (acetaminophen, amitriptyline, chlorpromazine,cimetidine, diazepam, doxylamine, ephedrine, imipramine, metoclopramide, propranolol, tramadol, and zolpidem) with frequent events of intoxication throughout the country and evaluated its clinical applicability. The overall sensitivity (low limit of quantitation, 0.1-0.5 μg/mL), specificity, precision and accuracy for the quantification of 12 drugs were reliable and all drugs can be analyzed within 6 min. Among 12 drugs in samples for quality control, the REMEDi HS-based method detected only 6 drugs with low accuracy, while the LC-MS/MS system was able to precisely quantify all drugs. In addition, pilot analysis of patient samples with unknown drug intoxication was superior to the conventional LC-based drug profiling system, and was rapid and cost effective. In conclusion, LC-MS/MS-based drug screening is a good replacement for conventional LC-based REMEDi analyzer and has the better clinical applicability.
김광렬,박상찬,조병렬 ( Kwang Yul Kim,Sang Chan Park,Byoung Real Cho ) 충북대학교 산업과학기술연구소 1990 산업과학기술연구 논문집 Vol.4 No.2
Abstract_Roman As one of energy resources, coal combustion is much utilized in many field of industries. During coal combustion, lots of polluting materials which are particule.tes, 143x, Sox etc are generated So the reaction mechanism of th- ese polluti