닛셀정에 대한 헤파필연질캡슐의 생물학적 동등성 평가

고인자,지상철,Ko, In-Ja,Chi, Sang-Cheol 대한약학회 2004 약학회지 Vol.48 No.6

Biphenyl dimethyl dicarboxylate (DDB) has been used for the treatment of chronic viral hepatitis B and drug-induced hepatitis through the inhibition of lipid peroxidation and c ovalent binding of drug metabolites to lipids of microsomes. The bioequivalence of two DDB products was evaluated according to the guidelines of KFDA. The test product was Hepaphil soft capsule(R) made by KMS Pharm. Co. Containing 3 mg DDB and the reference product was Nissel tablet(R) made by Taerim Pharm. Co. Containing 25 mg DDB. Twenty healthy male subjects, 25.4(22~30) years old and 66.7(54~77)kg, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets or two capsules were orally administered, blood was taken at predetermined time intervals and the concentration of DDB in plasma was determined using a validated HPLC method with UV detector. Two pharmacokinetic parameters, $AUC_t$ and $C_{max}$, were calculated and analyzed statistically for the evaluation of bioequivalence of the two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90% confidence intervals of $AUC_t$ and $C_{max}$ were log 0.91~log1.00 and log 1.05~log 1.15, respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Hepaphil soft capsule is bioequivalent to Nissel tablet.

한국산 하고초류의 약물학적 연구(Ⅰ) : 소염작용에 대하여

고인자(In Ja Ko),유승조(Seung Jo Yoo),이은방(Eun Bang Lee) 한국생약학회 1986 생약학회지 Vol.17 No.3

The whole plants of Prunella vulgaris (Labiatae) and Thesium chinense (Santalaceae) are used as Hakocho(夏枯草) in the market in Korea. In oriental medicine, these herb drugs are prescribed as a diuretic or antiinflammatory drugs. In order to investigate the efficacy of the plants, the extracts were bioassayed for antiinflammatory action. The water extracts of Prunella Herba and Thesii Herba showed remarkable anticarrageenin effect and significant inhibition of the swellings in adjuvant arthritis in rats. However, the extracts did not show any inhibition of leucocyte emigration in CMC pouch in rats.

한국산 하고초류의 약물학적 연구 (Ⅰ) : 소염작용에 대하여

고인자(In Ja Ko),유승조(Seung Jo Yoo),이은방(Eun Bang Lee) 한국생약학회 1985 생약학회지 Vol.16 No.1

The whole plants of Prunella vulgaris (Labiatae) and Thesium chinense (Santalaceae) are used as Ha-Ko-Cho(夏枯草) in market. In oriental medicine, these herb drugs are presribed as a diuretic or antiinflammatory drug. In order to investigate the efficacy of the plants, the water extracts were bioassayed for antiinflammatory action. Antiinflammatory effects were evaluated by carrageenin edema test, by Freund`s adjuvant arthritis method and by observing inhibition of leucocyte emigration in CMC pouch of rats. The water extract of Prunellae Herba at doses of 860㎎/㎏ (K^+; 82㎎) and 1, 710㎎/ kg; (K^+; 164㎎) p.o. and that of Thesii Herba at a dose of 1, 740㎎/㎏ (K^+; 206㎎) p.o. showed remarkable anti-carrageenin effects. The potassium also has anticarrageenin action at a dose of 250㎎, but no significant effect at a dose of 100㎎/㎏ p.o. The extracts of Prunellae Herba at a dose of 1, 710㎎/㎏ p.o. and Thesii Herba at a dose of 1, 740㎎/㎏ p.o. showed significant inhibition of the swellings in adjuvant arthritis. In the X-ray photograph of the Adjuvant arthritie feet, the water extracts inhibited considerablely the edema between the foot bones of rats. However, these extracts at the doses of 125 ㎎/rat s.c. did not show any inhibition of leucocyte emigration in CMC-pouch. From the above results, it was found that the water extracts of the herb drugs possessed antiinflammatory activity shown by anticarrageenin effect and antiswelling action in adjuvant arthritis. It is also noted that the potassium also play a role ao an effective constituents in anticarra geensin action.

한국산 하고초류의 약물학적 연구(Ⅱ) : 중추신경 및 이뇨작용에 대하여

고인자(In Ja Ko),유승조(Seung Jo Yoo),이은방(Eun Bang Lee) 한국생약학회 1986 생약학회지 Vol.17 No.3

This study is an attempt to investigate the effects of the water extracts of the whole plants of Prunella vulgaris (Labiatae) and Thesii chinense (Santalaceae) on the acute toxicity, the activities on central nervous system and the diuretic action. The acute toxicities shown by LD_(50) were estimated to be more than 3000 ㎎/㎏ p.o. and 1,000 ㎎/㎏ s.c. in the extracts of Prunellae Herba and Thesii Herba, respectively, in mice. The extracts at a dose of 2,000 ㎎/㎏ p.o. did not show any activities on central nervous system, i.e, sedative, analgesic, hypothermic and anticonvulsant actions. The urination in rats was increased by 45.5% and 57.6% when 100㎎/㎏ of each of the extracts were given orally. The results obtained revealed that the water extracts possessed weak diuretic actions without any of central nervous system activities. Furthermore, it is considered that the potassium in the extract may play a role in the diuretic action.

한국산 하고초류의 약물학적 연구 (Ⅱ) : 중추신경 및 이뇨작용에 대하여

고인자(In Ja Ko),유승조(Seung Jo Yoo),이은방(Eun Bang Lee) 한국생약학회 1985 생약학회지 Vol.16 No.1

This study is an attempt to investigate the effects of the water extracts of the whole plants of Prunella vulgaris (Labiatae) and Thesium chinense (Santalaceae) on acute toxicity, activities oncentral nervous system and the diuretic action. The acute toxicities of the extracts shown by LD_(50) were estimated to be more than 3,000㎎/㎏ p.o. and 1,000㎎/㎏ i.p. in mice. The extracts of the herb drugs at doses of 1, 000 and 2, 000㎎/㎏ p.o. did not show any activities on central nervous system, i. e. sedative, analgesic, hypothermic and anticonvulsant action. In diuretic action, the urination in rats was increased by 45.5% and 57. 6% when 1, 000㎎/㎏ of each of the extract of Prunellae Herba and Thesii Herba were given orally. The potassium contents in 1,000㎎ of the water extracts of Prunellae Herba and Thesii Herba were 96㎎ and 118㎎, respectively. From these results, it was revealed that the water extracts of the herb drugs possessed weak diuretic actions with least acute toxicities and without any of central nervous activities. Furthermore, it is considered that the potassium in the extract might play a role in diuretic action.

초등학교 과학과 "간이 소화기 만들기" 실험의 개선에 관한 연구

고영신 ( Young Sin Ko ),김선경 ( Sun Kyoung Kim ),김세경 ( Se Kyong Kim ),고인자 ( In Ja Ko ) 서울교육대학교 초등교육연구원 2005 한국초등교육 Vol.15 No.2

초등학교 과학과 "간이 소화기 만들기" 실험의 개선에 관한 연구 A Study about Improvement of Experiment of "Making Portable Fire Extinguishers" on Elementary School Science Textbooks

세로자트정(파록세틴 20㎎)에 대한 삼천리파록세틴정의 생물학적동등성

고인자,지상철 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

Paroxetine. a potent and selective serotonine reuptake inhibitor. has been used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. The bioequivalence of two paroxetine preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Samchullv Paroxetine tablet`' made by Samchullv Pharm. Co. and the reference product was Seroxat tablet made by GlaxoSmithKline. Twenty healthy male subjects. 22.4±2.6 years old and 63.8±4.2 kg. were divided into two groups and a randomized 2x2 cross-over study was employed. After one tablet containing 20 mg paroletine was orally administered. blood was taken at predetermined time intervals and the concentration of paroletine in plasma was determined using a validated HPLC method with fluorescence detector. Two pharmacokinetic parameters. AUCr and Cma.. were calculated and analyzed statistically for the evaluation of bioequivalence of two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90° 0 confidence intervals of AUCr and Cmax were log 0.84-log 1.16 and log 0.85-log 1.14. respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus. the criteria of the KFDA guidelines for the bioequivalence was satisfied. indicating that Samchullv Paroxetine tablet is bioequivalent to Seroxat tablet.

한국산 Cirsium속 식물의 생약학적 연구(I)

劉承兆,高仁玆 成均館大學校 1980 論文集 Vol.27 No.-

The Cirsium genus has been known as the original plant of Korean Dae-gye. It has been considered that cirsium Mackii Max. var. ussuriense Kitaumra and Crisium pendulum Fischer ex D. C., two kinds of the Cirsium genus, superficially resemble each other. In this paper, we compared Cirsium Maackii Max. var. ussuriense Kitamura and Cirsium pendulum Fisher ex D. C. in terms of morphology. That is, we examined length and thickness of stem, and figure of leaves and flowers for external morphology and investigated figure and size of endoermal serectory canal in cortex, types of vessel and existence of pith for internal morphology. We found out that there was a distinctive difference between Cirsium Maackii Max. var. ussuiense Kitamura and Cirsium pendulum Fischer ex D. C.. In order to check the above findings we also used T. L. C. to compare these two types and we aquired similar results.

산딸기 나무(Rubus crataegifolius BUNGE.)의 成分에 關한 硏究

유성호,곽종환,고인자,유승조 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1

Abstract-Rubus crataegifolius (Rosaceae) stems were dried, cut and extracted with MeOH, and then fractionated with Hexane, CHCI_3, and BuOH. Two compounds were isolated from CHCI_3 layer and EtoAc layer. The structures of these compound were elucidated by the physicochemical properties and instrumental approaches. Compound I, C_30H_48O_5, mp. 212∼3℃, a white crystals, were identified as tormentic acid (2α, 3β, 19α-trihydroxyurs-12-28-oic acid). Compound II, C_29H_50O, mp. 133∼6℃, a white crystals, were identified as β-sitosterol.

가는잎쐐기풀이 Alloxan 誘發 高血糖 쥐에 미치는 영향

도태자,곽종환,고인자,유승조 성균관대학교 약학연구소 1990 成均藥硏論文集 Vol.2 No.1

Abstratc-Urtica angustifolia has been used to cure diabetes etc. as a folk medicine. The anit-diabetic effect of U. angustifolia was investigated by the experimental diabetic model in rats. U. angustifolia extracts were administered before and after injection of alloxan(50 mg/kg, i.v.), and the blood glucose and serum cholesterol levels were determined at 3 days after alloxan injection. The increased blood glucose and serum total cholesterol levels in the diabetic rats induced by alloxan were significantly decreased by administration of MeOH and BuOH extracts, relatively. And reduced body weight was recovered with the treatments of each extract. The MeOH and BuOH extracts of U. angustifolia showed remarkable anti-diabetic effect, and MeOH extract showed more strong anti-diabetic effect than BuOH extract.