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고보건 ( Bo Gun Kho ),고명주 ( Myoung Ju Koh ),김우정 ( Woo Jeung Kim ),김희욱 ( Hee Wook Kim ),허철웅 ( Cheal Wung Huh ),정혜문 ( Hye Moon Chung ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Pulmonary sequestration is a rare congenital anomaly of the lung in which it is separately supplied from the aorta or one of its branches. Bilateral pulmonary sequestration is very rare, particularly in adults. In bilateral pulmonary sequestration, resection of both sides is usually recommended if both sides are infected and symptomatic. We report the case of a 37-year-old female patient with bilateral intralobar pulmonary sequestration treated by staged bilateral lower lobectomy.
우엔쫑니아 ( Trong-nghia Nguyen ),보탄헝 ( Thanh-hung Vo ),고보건 ( Bo-gun Kho ),이귀상 ( Guee-sang Lee ),양형정 ( Hyung-jeong Yang ),김수형 ( Soo-hyung Kim ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2
In-hospital cardiac arrest is a significant problem for medical systems. Although the traditional early warning systems have been widely applied, they still contain many drawbacks, such as the high false warning rate and low sensitivity. This paper proposed a strategy that involves a deep learning approach based on a novel interpretable deep tabular data learning architecture, named TabNet, for the Rapid Response System. This study has been processed and validated on a dataset collected from two hospitals of Chonnam National University, Korea, in over 10 years. The learning metrics used for the experiment are the area under the receiver operating characteristic curve score (AUROC) and the area under the precision-recall curve score (AUPRC). The experiment on a large real-time dataset shows that our method improves compared to other machine learning-based approaches.
도탄공 ( Thanh-cong Do ),양형정 ( Hyung-jeong Yang ),김수형 ( Soo-hyung Kim ),고보건 ( Bo-gun Kho ) 사단법인 한국빅데이터서비스학회 2023 빅데이터서비스학회 논문집 Vol.1 No.1
병원 환경 내에서 환자 상태의 악화가 발생하면 의료 서비스에 상당한 부담이 된다. 이러한 경우 신속한 임상 개입이 중요하며 임상 수치로부터 조기 징후를 감지하고 심정지를 예방하기 위해 중환자실(ICU)은 신속 대응 시스템(RRS)을 광범위하게 사용한다. 최근 몇 년 동안 심정지, 패혈증 예측 또는 ICU로의 이송과 같은 집중 치료 영역에서 딥러닝(DL) 및 전자 건강 기록(EHR)의 사용이 증가하고 있다. DL 기반 애플리케이션은 순차 시계열 데이터에서 학습할 수 있지만 해석력이 부족하여 민감도가 낮고 지연 경보율이 높아 임상에 적용하기 어렵다. 본 연구에서는 고차원 순차 데이터를 보간하여 심정지 환자의 이상 상태를 감지하는 해석 가능한 end-to-end 딥러닝 아키텍처를 제안한다. 실험은 전남대학교 병원(CNUH)에서 수집한 개인 임상 데이터 세트에서 수행되었고 실험 결과는 다른 최첨단 방법과 비교하여 우리 모델의 잠재적 성능을 보여주었다. In hospitals globally, the occurrence of clinical deterioration within the hospital setting poses a significant burden on healthcare. Rapid clinical intervention becomes a crucial task in such cases. To detect early signs of clinical decline and prevent cardiac arrest, the intensive care units (ICUs) widely employ rapid response systems (RRSs). In recent years, there has been an increasing use of deep learning (DL) and electronic health records (EHR) in the intensive care domain, such as the prediction of cardiac arrest, sepsis, or transferring to ICUs. DL-based applications are able to learn from sequential time-series data. However, their lack of interpretability leads to low sensitivity and high late alarm rates, and are thus difficult to apply to the clinical settings. In this research, we propose an interpretable end-to-end deep learning architecture that interpolates high-dimensional sequential data and detects the abnormal status of cardiac arrest patients. The experiments are conducted on a private clinical dataset collected from Chonnam National University hospital (CNUH). The experimental results have shown the potential performance of our model, compared to some other state-of-the-art methods.
허철웅 ( Cheal Wung Huh ),윤영훈 ( Young Hoon Youn ),정다현 ( Da Hyun Jung ),김도환 ( Do Whan Kim ),고보건 ( Bo Gun Kho ),김지현 ( Jie Hyun Kim ),박효진 ( Hyo Jin Park ),이상인 ( Sang In Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.4
Cytomegalovirus (CMV) colitis is common among immunocompromised patients, and often diagnosed by pathologic confirmation because it is associated with a diverse spectrum of clinical and endoscopic features. However, Crohn`s disease has no definitive diagnostic criteria, but longitudinal ulcers and cobble stone appearance are accepted as typical endoscopic features of Crohn`s disease. An 83 year-old male with a history of radiotherapy for hypopharyngeal cancer visited our hospital with a complaint of melena for 1 week. His colonoscopic exam showed multiple longitudinal ulcers along the entire colon. Most of the ulcers were longer than 4 cm, these endoscopic findings were suspected as typical endoscopic features of Crohn`s disease. Pathologic reports revealed multiple inclusion bodies with CMV on immunohistochemistry. He was finally diagnosed as having CMV colitis, and received a 3 week-course of intravenous ganciclovir. A colonoscopic follow-up showed complete healing of the multiple longitudinal ulcers, and he is doing well now without further treatment. (Korean J Gastroenterol 2012;59:303-307)
증례 : 혈액종양 ; 복강 내에서 발견된 기관지원성낭종 내의 선암 1예
박지수 ( Ji Soo Park ),김종원 ( Jong Won Kim ),임범진 ( Beom Jin Lim ),박승교 ( Seung Kyo Park ),고보건 ( Bo Gun Kho ),임재윤 ( Jae Yun Lim ),조재용 ( Jae Yong Cho ) 대한내과학회 2012 대한내과학회지 Vol.82 No.3
Gastric foregut duplication cyst is a rare congenital anomaly. There have been very few reports of bronchogenic cysts in the abdominal cavity attached to the stomach. We report a case of a 57-year-old Korean man with an adenocarcinoma arising within a bronchogenic cyst of the stomach. Pathologic findings revealed ciliated columnar epithelium lining the cyst and a solid papillary adenocarcinoma involving the subserosa of the stomach and the skeletal part of the diaphragm. Surgical resection is the treatment of choice for foregut cysts of the stomach, and the possibility of malignancy should be considered in patients with gastric duplication cysts. (Korean J Med 2012;82:374-377)
비소세포폐암 환자에서 부종양성 증후군의 증상으로 발생한 좌측 3, 4 뇌신경 마비
이영미 ( Young Mi Lee ),심우호 ( Woo Ho Sim ),윤선옥 ( Sun Och Yoon ),김송이 ( Song Yee Kim ),박정수 ( Jung Soo Park ),고보건 ( Bo Gun Kho ),변민광 ( Min Kwang Byun ),최영철 ( Young Chul Choi ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.2
Paraneoplastic neurologic syndrome is a group of assorted disorders resulting from damage to the nervous system in cancer, remote from primary site, and not related to metastasis, infection, or metabolic disorder associated with cancer. Patient with small cell lung cancer sometimes shows various neurological syndromes, but patient with non-small cell lung cancer rarely shows neurologic syndromes and few antineuronal antibodies have been found. Here, we report a case of 53-year-old male patient who developed ptosis and extraocular muscular limitation of left eye due to third and forth cranial nerve palsy in non-small cell lung cancer without brain metastasis. These neurologic symptoms improved after lobectomy without any other treatment immunotherapy.