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침샘관암에서 PD-L1의 발현율 분석과 종양 표지자로서의 효용성에 대한 고찰
이용주,고윤우,윤선옥,류향주,김혜련,신향애,Lee, Yong Ju,Koh, Yoon Woo,Yoon, Sun Och,Ryu, Hyang Joo,Kim, Hye Ryun,Shin, Hyang Ae 대한두경부종양학회 2019 대한두경부 종양학회지 Vol.35 No.1
Background/Objectives: Despite multiple approaches of treatments for salivary duct carcinoma, there has been a need for more successful treatment methods because of its poor prognosis. Treatment options like immunotherapy using new technologies have been attempted. Based on recent study results indicating that targeting programmed death receptors are effective in treating various cancers, this study aimed to identify the frequency of PD-L1 expression and its impact on survival rate in salivary duct carcinoma. Materials & Methods: We studied 33 patients with salivary gland cancer who were available for histologic specimens. We examined the expression of PD-L1 in the tissues and analyzed the association with the survival rate and the association with various clinical parameters. Results: According to this study and review of similar studies, we discovered that the expression of PD-L1 in salivary duct carcinoma was lower than other types of cancers. The impact of PD-L1 on survival rate also showed inconsistency in salivary duct carcinoma. Conclusion: Immunotherapy by PD-1/PD-L1 checkpoint blockade in salivary duct carcinoma needs further evaluation for clinical application.
마대원 ( Dae Won Ma ),김민경 ( Min Kyung Kim ),윤선옥 ( Sun Och Yoon ),이광원 ( Kwang Won Rhee ),윤동섭 ( Dong Sup Yoon ),박효진 ( Hyo Jin Park ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.3
Gastrointestinal neuroendocrine tumors arise from cells of the diffuse neuroendocrine system and can take place almost anywhere within the gastrointestinal tract. A 40-year-old man admitted to evaluate a duodenal subepithelial lesion which was incidentally found at health check-up. The polypoid duodenal subepithelial lesion, measuring about 7 mm, was removed by the endoscopic mucosal resection and the pathology confirmed a neuroendocrine tumor. Abdominopelvic computed tomography, done for staging work up, revealed a mass in the pancreatic head and the patient received pylorus preserving pancreaticoduodenectomy. Mass at the pancreas also found out to be neuroendocrine tumor but showed different histopathologic traits under immunohistochemical staining. The patient was also diagnosed as hyperparathyroidism and pituitary microadenoma. Finally, multiple endocrine neoplasia type 1 was confirmed, which was accompanied by duodenal neuroendocrine tumor. (Korean J Gastroenterol 2013;61:155-159)
홍제범 ( Je Beom Hong ),홍창기 ( Chang Ki Hong ),이규성 ( Kyu Sung Lee ),윤선옥 ( Sun Och Yoon ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2011 대한뇌종양학회지 Vol.10 No.2
We present a case of spinal accessory nerve cavernous hemangioma. A 44-year-old male patient visited our hospital because a mass at his foramen magnum had been found during a medical checkup. A magnetic resonance (MR) image revealed a well-enhanced mass in the foramen magnum, with displacement of the medulla oblongata to the left side by this mass. The lesion was resected using a far-lateral approach, and the pathological diagnosis was a cavernous hemangioma. Although cranial nerve cavernous hemangioma is a rare condition, it should be considered when making differential diagnoses of foramen magnum masses.
비소세포폐암 환자에서 부종양성 증후군의 증상으로 발생한 좌측 3, 4 뇌신경 마비
이영미 ( Young Mi Lee ),심우호 ( Woo Ho Sim ),윤선옥 ( Sun Och Yoon ),김송이 ( Song Yee Kim ),박정수 ( Jung Soo Park ),고보건 ( Bo Gun Kho ),변민광 ( Min Kwang Byun ),최영철 ( Young Chul Choi ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.2
Paraneoplastic neurologic syndrome is a group of assorted disorders resulting from damage to the nervous system in cancer, remote from primary site, and not related to metastasis, infection, or metabolic disorder associated with cancer. Patient with small cell lung cancer sometimes shows various neurological syndromes, but patient with non-small cell lung cancer rarely shows neurologic syndromes and few antineuronal antibodies have been found. Here, we report a case of 53-year-old male patient who developed ptosis and extraocular muscular limitation of left eye due to third and forth cranial nerve palsy in non-small cell lung cancer without brain metastasis. These neurologic symptoms improved after lobectomy without any other treatment immunotherapy.