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구자석,허남원,강신원 ( Ja Seok Koo,Nam Won Huh,Shin Won Kang ) 한국유화학회 1987 한국응용과학기술학회지 Vol.4 No.2
The addition of dipeptides and 1,2-bis (aminoacyl) hydrazine derivatives a level of 250 ppm to corn oil resulted in the retardation of the oxidaitive deterioration of the oil when it was stored in the oven at 70℃ during 5 days. Their antioxidant activities were investigated by UV absorbance of the corn oil at the wavelength of 234nm. 1,2-bis (aminoacyl) hydrazine derivatives showed higher antioxidant activity than normal dipeptides. Dipeptides containing phenyl ring with which is conjugable a-carbon radical showed antioxidant activity.
문성환,김종안,김경희,구자석,허남원,김동규,신흥대,강신원,Moon, Sung-Hwan,Kim, Jong-Ahn,Kim, Keung-Hee,Koo, Ja-Seok,Huh, Nam-Won,Kim, Dong-Kyu,Shin, Hong-Dae,Kang, Shin-Won 생화학분자생물학회 1987 한국생화학회지 Vol.20 No.4
페니실린 G와 펩타이드의 유리딘 유도체를 합성하여 쥐의 lymphoblastoma L5178Y 세포와 Staphylococcus aureus(IAM 3610) 그리고 Escherichia coli(ATCC 10536)에 대해서 생물 활성 실험을 행하였다. 본 연구에 이용된 합성 화합물들은 5'-amino-5'-deoxyuridine-penicillin G(14), 5'-amino-5'-deoxyuridine-cyclo (Phe-Asp) (15-I). 5's-amino-5'-deoxyuridine-cyclo (Phe-Glu) (15 -II), 5'-iodo-5'-amino-2', '3'-isopropylidene uridine-penicillin G (16), 5'-iodo-5'-amino-5'-deoxyuridine-penicilline G (17), 그리고 5'-deoxyuridine-penicilline G (19) 등을 사용하였다. 이들 각각의 $IC_{50}$ 값은 $18.0\;{\mu}g/ml$, $6.5\;{\mu}g/ml$, $6.5\;{\mu}g/ml$, $13.5\;{\mu}g/ml$, $6.5\;{\mu}g/ml$ 그러고 $9.0\;{\mu}g/ml$로 나타났다. 또한 (15-I)과 (17)의 MIC 값이 $6.25\;{\mu}g/ml$로 나타났다. 이러한 일차적인 결과는 유리딘이나 페니실린 또한 펩타이드가 conjugate 됨으로써 더욱더 생물활성을 개선시키는 결과를 보여 주고 있다. Six new uridine-conjugates of penicillin G and peptides have been prepared and evaluated against mouse lymphoblastoma L5178Y cells, Staphylococcus aureus(IAM 3610) and Escherichia coli(ATCC 10536). These include 5'-amino-5'-deoxyuridine-penicillin G(14), 5'-amino-5'-deoxyuridine-cyclo (Phe-Asp)(15-I). 5'-amino-5'-deoxyuridine-cyclo (Phe-Glu)(15-II), 5-iodo-5'-amino-2',3'-0-isopropylidene uridine- penicillin G(16), 5-iodo-5'-amino-5'-deoxyuridine-penicillin G(17), and 5'-deoxyuridine-penicillin G(19). $IC_{50}$ values were $18.0\;{\mu}g/ml,$ $6.5\;{\mu}g/ml,$. $6.5\;{\mu}g/ml,$ $13.5\;{\mu}g/ml$, $6.5\;{\mu}g/ml$ and $9.0\;{\mu}g/ml$, respectively. MIC values of (15-I) and (17) were $6.25\;{\mu}g/ml,$. These preliminary results support the thesis that the uridine conjugates of this type may require a naturally occurring moiety for improved efficacy.
누클레오시드 유도체의 약품 구상 , 합성 및 생리 활성 연구
문성환,김종안,김경희,구자석,허남원,김동규,신홍대,강신원 ( Sung Hwan Moon,Jong Ahn Kim,Keung Hee Kim,Ja Seok Koo,Nam Won Huh,Dong Kyu Kim,Hong Dae Shin,Shin Won Kang ) 생화학분자생물학회 1987 BMB Reports Vol.20 No.4
Six new uridine-conjugates of penicillin G and peptides have been prepared and evaluated against mouse lymphoblastoma L5178Y cells, Staphylococcus aureus(IAM 3610) and Escherichia coli (ATCC 10536). These include 5`-amino-5`-deoxyuridine-penicillin G(14), 5`-amino-5`-deoxyuridine-cyclo(Phe-Asp)(15-I), 5`-amino-5`-deoxyuridine-cyclo (Phe-Glu)(15-II), 5-iodo-5`-amino-2`,3`-0-isopropylidene uridine-penicillin G(16), 5-iodo-5`-amino-5`-deoxyuridine-penicillin G(17), and 5`-deoxyuridine-penicillin G(19). IC_(50) values were 18.0 ㎍/㎖, 6.5 ㎍/㎖, 6.5 ㎍/㎖, 13.5 ㎍/㎖, 6.5 ㎍/㎖ and 9.0 ㎍/㎖, respectively. MIC values of (15-I) and (17) were 6.25 ㎍/㎖. These preliminary results support the thesis that the uridine conjugates of this type may require a naturally occuring moiety for improved efficacy.