Fatal Breakthrough Mucormycosis in an Acute Myelogenous Leukemia Patient while on Posaconazole Prophylaxis

강승훈,김현선,배명남,김지혜,유지연,이관용,이동건,김희제 대한감염학회 2015 Infection and Chemotherapy Vol.47 No.1

Posaconazole is a new oral triazole with broad-spectrum antifungal activity. Posaconazole has also shown a significant advantageof preventing invasive fungal infection compared to fluconazole or itraconazole in patients with prolonged neutropenia. Indeed, posaconazole has been commonly used for antifungal prophylaxis in patients undergoing remission induction chemotherapyfor acute myelogenous leukemia or myelodysplastic syndrome. We experienced a case of fatal mucormycosis despiteposaconazole prophylaxis. To our knowledge, this is the first reported case of fatal breakthrough mucormycosis in a patientreceiving posaconazole prophylaxis during remission induction chemotherapy in Korea. This case demonstrated that breakthroughfungal infection can occurs in patients receiving posaconazole prophylaxis because of its limited activity against somemucorales.

제53차 춘계학술대회 : 증례보고 6-선천성/유전성 질환 ; 모발, 조갑, 청력 및 생식기 이상을 보인 환자 1예

강승훈,김정욱,박성욱,왕한영 대한피부과학회 2001 초록집 Vol.39 No.10

탄성 가중치를 이용한 다수 무인항공기의 편대비행 및 충돌회피

강승훈,최현진,김유단 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.11

본 연구는 다수 무인항공기의 편대비행 시 발생하는 충돌상황에 대해 충돌을 회피하고 편대를 재구성하는 방법을 다룬다. 기존의 편대비행 및 충돌회피 방법은 편대구성과 충돌회피에 대한 가중치가 임의로 부여되기 때문에 상황에 따른 능동적인 대처가 어렵다는 문제가 있다. 이에 본 연구에서는 외부 자극에 의해 변형을 일으킨 후 원래의 형태를 회복하는 형상기억수지의 탄성적 특성을 응용하여 거리에 따라 탄력적으로 가중치를 변화시키도록 함수를 구성하였고, 이를 이용하여 편대비행과 충돌회피를 결합하였다. 개별적인 편대구성, 장애물 회피 그리고 편대 재구성은 방향각과 속력 명령을 추종함으로써 이루어지고, 이에 대한 방향 벡터에 탄성가중치를 적용하였다. 제안된 방법은 르야프노프 안정성 이론을 이용하여 안정성을 검증하였고, 수치 시뮬레이션을 통해 성능을 확인하였다. In this study, a formation flight and collision avoidance of multiple Unmanned Aerial Vehicles(UAVs) guidance law is proposed. Generally, to deal with the situation of collision avoidance and reformation, arbitrary weight value is assigned to collision avoidance command and formation reconfiguration command. This approach, however, cannot cope with unexpected situation of collision adaptively. In this study, inspired by shape memory polymer’s elastic behavior that tends to regain its original shape after deformation by certain external stimuli such as heat, weight value function is introduced in a continuous form that varies with respect to distance between UAV and obstacle or other UAVs. Also, heading angle command and speed command are generated to make UAV construct formation and follow reference trajectory. The stability of the proposed guidance law is proved using Lyapunov Theorem, and numerical simulation is performed to verify the performance of the proposed method.

교각 안정화 운동이 몸통 근육의 근활성도와 근활성도 비에 미치는 영향

강승훈,이수영 기독보건학회 2014 전인건강과학회지 Vol.4 No.2

The purpose of this study was to investigate both relative muscle activity levels and ratios of local to global muscle activity, during bridging stabilization exercises. Twenty-fours healthy students volunteered to participate in this study. Subjects were required to complete the following four exercises: exercise 1, bridging position exercise: exercise 2, bridging position exercise with right leg lift exercise: exercise 3, bridging position exercise with right leg lift and hip/knee 0°∼90° flexion: exercise 4, bridging position exercise with right leg lift and swiss ball under leg, hip 0°∼30° abduction. Surface EMG signals were recorded from internal oblique (IO), rectus abdominal (RA), multifidus (MF), erecter spinae (ES) muscle during the exercises. RMS (root mean square) from selected trunk muscle was normalized by maximum voluntary isometric contraction (MVIC). One-way repeated of ANOVA with post-hoc Bonferroni`s correction was used to compare the differences in the muscle activity levels and ratios according to the types of exercise. The results of these muscles activites are as follows: The EMG activities of the muscles in exercise 2 showed significantly higher than those of muscle in exercise 1, 3, 4 (p<.05). The results of these muscles activity ratios are as follows: During all bridging exercises, the ratio of the IO/RA was very high due to relatively minimal activity of the rectus abdominis (RA). The relative muscle activity and the ratio of the back muscle demonstrated similar activity levels for all exercise. This study suggests that bridging exercise with leg lift is the most effective in lumbar bridging stabilization exercise. Also we provide useful information that will inform future studies on how bridging stabilization exercise affects muscle activity levels and ratios of local to global muscle activity.

예쁜꼬마선충 동물 모델 기반 신약 스크리닝 기계 · 바이오 융합 기술

강승훈,신용운,임승은,최신식 대한기계학회 2023 기계저널 Vol.63 No.6

공정거래위원회의 디지털증거 수집의 적법성 강화 방안

강승훈 한국경쟁법학회 2019 競爭法硏究 Vol.39 No.-

Due to the development and advancement of information technology, a object of administrative investigation is rapidly being replaced by digital evidence from material things. In response to this situation, several administrative agencies with authority to conduct administrative investigation have set up procedures and standards for collecting digital evidence, and have established an organization dedicated to the related tasks. The Fair Trade Commission(FTC) is a collegiate governmental authorities that independently conducts affairs under Monopoly Regulation and Fair Trade Act(MRFTA) through the investigation and deliberation of the violation of MRFTA. It declares itself to be in violation of the law and has the authority to impose fines and prosecute prosecutions. FTC has expanded the scope of investigation through the collection of digital evidence in order to detect cases of law violations more efficiently in case processing procedures. Due to the characteristic of digital evidence, collecting digital evidence for administrative investigations is more likely to infringe on the rights and freedoms of the people than the investigations of material things. Therefore, the conduct should be controlled according to lawful and due process. This study started with the consciousness of the issue of whether FTC's digital evidence collection procedure is operated through due process of law. As a result, it can be raised under the existing laws and related regulations, I recognized the problem as follows. First, under the current legal system, the procedure of collecting digital evidence by FTC is judged to be in violation of the due process principle guaranteed by the Constitution because it is not conducted in accordance with a legal basis. Second, considering that FTC has a role as the first instance court, the point that examine of evidence for digital evidence presented in the deliberation process of FTC is not practically achieved can be contrary to the constitutional principle of guaranteeing the right of access to courts. Recognizing these problems, I suggest to strengthen the legitimacy of the digital evidence collection process of FTC as follows. First, the essentials of the legal basis for collecting digital evidence of FTC should be enacted as laws. Second, the FTC's deliberation procedure should strengthen the procedures for examine of evidence for digital evidence. The purpose of this paper is to verify the meaning and nature of the digital evidence collection activities of FTC and to provide the procedural requirements and procedural procedures. As a result it is meaningful that the legality of FTC enforcement is strengthened.

Right aortic arch with aberrant left subclavian artery and Kommerell`s diverticulum. Diagnosed with ancillary help of endoscopic ultrasound

강승훈,박낙순,류호상,김창덕,엄순호,전훈재,이홍식,진윤태,서연석,김용식,금보라 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Dysphagia resulting from esophageal compression by anomalous aortic arch vessels is not common, often overlooked without every single effort to find out the reason. In case that endoscopy or barium swallow to evaluate dysphagia shows extrinsic esophageal compression, the next step like EUS, CT or MR imaging is generally considered to evaluate the cause of compression. CT or MR imaging is very excellent to figure out the correlation between the esophagus and its surrounding structure. But the anomaly of aortic arch is frequently ignored in review of CT or MR imaging with little attention to vascular structure because it is a very rare etiology of dysphagia. Herein, we report a case in which EUS and 3D-CT were used to establish the diagnosis of dysphagia due to congenital vascular anomaly, right aortic arch with aberrant left subclavian artery with Kommerell`s diverticulum.

연구포스터발표 : 세포부착에 관여하는 펩타이드를 흡착시킨 골이식재에 대한 골아세포의 활성능에 대한 평가

강승훈,박진우,이재목,서조영 대한치주과학회 2004 대한치주과학회 학술대회자료집 Vol.2004 No.2

Assessment of Recovery Medium for Production of hCTLA4Ig after Cryopreservation in Transgenic Rice Cells

강승훈,최홍열,조지숙,전수환,김지연,Brian B. Kim,김동일 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.2

A reproducible method for cryopreservation of transgenic rice cells (Oryza sativa L. cv. Dongjin) producing recombinant human cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (hCTLA4Ig) has been established. Here, we assessed recovery media and investigated recombinant protein homogeneity after long-term preservation. For recovery of cryopreserved transgenic rice cells, AA medium was suitable in terms of both morphology and production of hCTLA4Ig. There were no differences in cell growth, sugar consumption, and hCTLA4Ig production between non-cryopreserved and cryopreserved cells for up to 1 month. hCTLA4Ig produced from cryopreserved cells was identical that of hCTLA4Ig from non-cryopreserved cells, as determined by analysis of its molecular weight and isoforms. For long-term preservation, cell viability was stably maintained at 61% for 26 months. In conclusion, these results demonstrate the possibility for reproducible cryocell-banking of transgenic rice cells without changes in the characteristics of cells and target proteins.

Strain effects on phase transitions in transition metal dichalcogenides

강승훈,권영균 한국물리학회 2019 Current Applied Physics Vol.19 No.6

We perform density functional theory calculation to investigate the structural and electronic properties of various two-dimensional transition metal dichalcogenides, MX2 (M=Ti, V, Cr, Zr, Nb, Mo, Hf, Ta, or W, and X=S or Se), and their strain-induced phase transitions. We evaluate the relative stability and the activation barrier between the octahedral-T and the trigonal-H phases of each MX2. It is found that the equilibrium and phase transition characteristics of MX2 can be classified by the group to which its metal element M belongs in the periodic table. MX2 with M in the group 4 (Ti, Zr, or Hf), forms an octahedral-T phase, while that with an M in the group 6 (Cr, Mo, or W) does a trigonal-H phase. On the other hand, MX2 with M in the group 5 (V, Nb, or Ta), which is in-between the groups 4 and 6, may form either phase with a similar stability. It is also found that their electronic structures are strongly correlated to the structural configurations: mostly metallic in the T phase, while semiconducting in the H phase, although there are some exceptions. We also explore the effects of an applied stress and find for some MX2 materials that the resultant strain, either tensile or compressive, may induce a structural phase transition by reducing the transition energy barrier, which is, in some cases, accompanied by its metal-insulator transition.