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尹熙雄,卞基洙,李在春,朴鍾勳 中央醫學社 1972 中央醫學 Vol.22 No.4
Among antibiotics colistin and gentamicin are drugs of highly sensitive to Pseudomonas both in vitro and in vivo test. However, gentamicin is still limited use clinically as compared to the broad application of colistin. Authors have studied the sensitivity patterns of Pseudomonas aeruginosa isolated from various pathologic sources against both drugs as well as the effect of combined action of these drugs. Combined action of both drugs exhibited a slight synergistic action on the inhibitory and the lethal action to the test strains and resistance formation of Ps.aeruginosa to gentamicin was not observed by serial passage in drug added media. Most of isolated strains were more sensitive to gentamicin than colistin, and vaginal strains were homogenous in sensitivity patterns than strains of other sources.
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尹熙雄,鄭在奎 中央醫學社 1972 中央醫學 Vol.23 No.2
As Pyocine type I of P seudonas aruginosa by the method of Giliies and Govan occupies a majority of strains typed, subtyping of Type I is necessary to increase the significance of pyocine typing in the epidemiology of Pseudomonas aeruginosa infections. The author tried to type I strains isolated from various wound infections (general strain) and viginal cavities (vaginal strains) into subgroups. Strains used as indicator are 74 untypable strains of stock cultures. Among indicators used, 37 strains were considered of no value since they were completely inhibited or resistant to all pyocine-producine strains. Among rest of 37 indicators, 9 strains were resistant to all vaginal producer strains but inhibited by some general strains, and 4 strains were on the contrary inhibited by all vaginal strains but resistant to some general strains. The rest of 24 strains exhibited various patterns by producer strains. From 24 indicators, 5 strains were selected to formulate a subtyping pattern. With the formula general strains and vaginal strains can be subtyped, but still exhibited a significant differences between both groups in subtyped pyocine patterns.
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윤희웅,최병현,Park Do Young,Jin Long Hao,민병현 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5
Background: The extracellular matrix (ECM) of articular cartilage has an inhibitory effect on vascularization, yet clinical utilization has been technically challenging. In this study, we aimed to fabricate a biologically functional ECM powder suspension from porcine articular cartilage that inhibits neovascularization (NV). Methods: The digested-cartilage acellular matrix (dg-CAM) was prepared by sequential processes of decellularization, enzymatic digestion and pulverization. Physicochemical properties of dg-CAM were compared with that of native cartilage tissue (NCT). Cellular interactions between human umbilical vein endothelial cells (HUVECs) and dg-CAM was evaluated with proliferation, migration and tube formation assays compared with that of type I collagen (COL) and bevacizumab, an anti-angiogenic drug. We then investigated the therapeutic potential of topical administration of dg-CAM suspension on the experimentally induced rabbit corneal NV model. Results: The dg-CAM released a significantly larger amount of soluble proteins than that of the NCT and showed an improved hydrophilic and dispersion properties. In contrast, the dg-CAM contained a large amount of collagen, glycosaminoglycans and anti-angiogenic molecules as much as the NCT. The inhibitory effect on NV of the dg-CAM was more prominent than that of COL and even comparable to that of bevacizumab in inhibiting the HUVECs. The therapeutic potential of the dg-CAM was comparable to that of bevacizumab in the rabbit corneal NV model by efficiently inhibiting neovessel formation of the injured cornea. Conclusion: The current study developed a dg-CAM having anti-angiogenic properties, together with water-dispersible properties suitable for topical or minimally invasive application for prevention of vessel invasion.
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윤희웅(Yoon, Hee Woong),김가영(Kim, Ka Young) 한국증권법학회 2013 증권법연구 Vol.14 No.2
종전에 우리나라에서는 이른바 ‘삼각합병’이 불가능하였으나, 2012년 4월 15일부터 시행된 개정상법에서는 삼각합병이 도입되었다. 이러한 삼각합병의 허용은 M&A의 활성화 및 기업구조조정의 원활화를 꾀하고자 하는 취지로 이루어진 것이다. 그리고 지난 2012년 11월, 삼각합병제도가 도입된 후 처음으로 실제 삼각합병이 이루어졌다. 다만, 그 이후로는 아직까지 삼각합병의 실제 사례는 없는 것으로 보인다. 이 글에서는 삼각합병의 개념에 대하여 살펴본 뒤, 우리나라에서 이루어진 삼각합병의 첫 사례와 외국의 사례를 참고로 하여, 삼각합병의 절차를 설명하고, 이와 관련한 법적 문제들에 대하여 검토해 보았다. 삼각합병 절차와 관련하여, 법적으로 짚어 보아야만 할 쟁점들이 많은 것으로 보인다. 다만, 개정상법에서도 그런 법적인 쟁점에 대한 구체적인 규정을 두지 않았고, 국내에서는 그에 대한 논의도 아직 활발하지 않고 확립된 견해도 없어서 삼각합병 제도에 대한 분석이 제대로 이루어지고 있지 못하다. 따라서 이 글에서는 실무자의 입장에서 문제될 만한 사항들에 대하여 가능한 범위 내에서 합리적인 결론을 내려 보기 위해 노력해 보았다. 상법규정만으로는 삼각합병의 구체적인 절차와 내용이 불명확하여 아직까지 삼각 합병이 많이 활용되고 있지 못한 것으로 생각된다. 이 글이 삼각합병 제도에 대한 학자들과 실무자 및 입법자들의 관심을 불러일으켜, 해석론과 입법을 통해 삼각합병제도가 명확하게 정비되고, 실무에서 보다 활발하게 이용될 수 있기를 바란다. The new Commercial Law entered into force on April 15th, 2012 allows so-called “triangular mergers” that had been previously unlawful. This partial amendment was intended to revitalize the wave of Mergers & Acquisitions and make corporate restructuring smoother. The first triangular merger case was accomplished on last November, 2012 for the first time since its inception; however, there has not been any other cases reported later on. This paper examines the concept of triangular merger, explains the procedure of the merger with reference to the first case in Korea and other examples from countries abroad and considers relevant legal issues from all viewpoints. It seems to be appropriate to examine thoroughly many a legal issue in relation to the procedure of triangular merger. Unfortunately, it must be pointed out that the revised Commercial Law did not clearly stipulate the specific scope and extent of regulations with regard to such legal issues, nor did it create animated discussions and well-settled points of view, resulting in a poor showing of analysis on the system of triangular merger. Therefore, this paper expended efforts to make reasonable conclusions within practicable limits on the issues that can be problematic from the eyes of practicing professionals. It is presumed that commercial codes nowadays are vaguely defined in terms of specific procedures and contents such that the triangular merger has not been widely utilized so far. It is desirable that this paper attracts attention from scholars and practicing professionals regarding triangular merger and helps modify the system through pertinent methodology and legislation and eventually leads to vigorous use in practice.
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